Neuroprotective strategies in Alzheimer's disease (Q81411926)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717012 AND SRC:MED&resulttype=core&format=json

8 January 2020

review article

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title

Neuroprotective strategies in Alzheimer's disease (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717012 AND SRC:MED&resulttype=core&format=json

8 January 2020

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Frank M Longo

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717012 AND SRC:MED&resulttype=core&format=json

8 January 2020

Stephen M Massa

series ordinal

2

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8 January 2020

publication date

1 January 2004

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717012 AND SRC:MED&resulttype=core&format=json

8 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717012 AND SRC:MED&resulttype=core&format=json

8 January 2020

volume

1

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8 January 2020

issue

1

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8 January 2020

page(s)

117-127

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Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.

8 January 2020

cites work

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12 December 2020

Targeting the JNK pathway for therapeutic benefit in CNS disease

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12 December 2020

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein

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12 December 2020

Abeta immunization and anti-Abeta antibodies: potential therapies for the prevention and treatment of Alzheimer's disease

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12 December 2020

Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases

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12 December 2020

Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease

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12 December 2020

The production of amyloid beta peptide is a critical requirement for the viability of central neurons.

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12 December 2020

A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons

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12 December 2020

Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease

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12 December 2020

Coupling of the p75 neurotrophin receptor to sphingolipid signaling.

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12 December 2020

The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3.

1 reference

12 December 2020

Alterations in trk A, trk B and trk C receptor immunoreactivities in parietal cortex and cerebellum in Alzheimer's disease

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12 December 2020

Long-term effects of rivastigmine in moderately severe Alzheimer's disease: does early initiation of therapy offer sustained benefits?

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12 December 2020

Modulation of beta-amyloid precursor protein processing and tau phosphorylation by acetylcholine receptors

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12 December 2020

The many faces of p75NTR.

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12 December 2020

Ironic fate: can a banned drug control metal heavies in neurodegenerative diseases?

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12 December 2020

Traffic at the intersection of neurotrophic factor signaling and neurodegeneration

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12 December 2020

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor

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12 December 2020

Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation

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12 December 2020

Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease

1 reference

12 December 2020

Mechanisms of amyloid beta protein-induced modification in ion transport systems: implications for neurodegenerative diseases

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12 December 2020

Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases

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12 December 2020

Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies

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12 December 2020

Caspases, apoptosis, and Alzheimer disease: causation, correlation, and confusion

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12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

Memantine is highly potent in protecting cortical cultures against excitotoxic cell death evoked by glutamate and N-methyl-D-aspartate

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12 December 2020

Role of neurotrophins in central synapse formation and stabilization.

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12 December 2020

Alzheimer's therapeutics: neurotrophin small molecule mimetics

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12 December 2020

Nerve growth factor potentiates the neurotoxicity of beta amyloid

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12 December 2020

CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis

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12 December 2020

Inflammation takes on Alzheimer disease

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12 December 2020

Dietary intake of antioxidants and risk of Alzheimer disease

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12 December 2020

Nerve growth factor (NGF) loop 4 dimeric mimetics activate ERK and AKT and promote NGF-like neurotrophic effects

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12 December 2020

Estrogen-mediated neuroprotection against beta-amyloid toxicity requires expression of estrogen receptor alpha or beta and activation of the MAPK pathway

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12 December 2020

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study

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12 December 2020

Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease

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12 December 2020

Amyloid beta-peptide induces cholinergic dysfunction and cognitive deficits: a minireview

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12 December 2020

Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study

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12 December 2020

Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons.

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12 December 2020

Growth-factor gene therapy for neurodegenerative disorders

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12 December 2020

The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease

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12 December 2020

The pathogenesis of Alzheimer's disease. Is amyloid beta-protein the beginning or the end?

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12 December 2020

The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease

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12 December 2020

Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review

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12 December 2020

Development of pharmacological agents for targeting neurotrophins and their receptors

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12 December 2020

The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling

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12 December 2020

Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis

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12 December 2020

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

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12 December 2020

Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases

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12 December 2020

Increased p75(NTR) expression in hippocampal neurons containing hyperphosphorylated tau in Alzheimer patients

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12 December 2020

alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity

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12 December 2020

Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh.

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12 December 2020

The metallobiology of Alzheimer's disease

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12 December 2020

Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous.

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12 December 2020

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

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12 December 2020

Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection

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12 December 2020

Expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 in the somatosensory cortex of the mature rat: coexpression with high-affinity neurotrophin receptors

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12 December 2020

Alzheimer's disease is a synaptic failure

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12 December 2020

Molecular mechanisms for neuronal cell death by Alzheimer's amyloid precursor protein-relevant insults

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12 December 2020

Dietary intake of antioxidants and risk of Alzheimer disease: food for thought.

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12 December 2020

beta-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimer's disease.

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12 December 2020

Alzheimer disease therapy: can the amyloid cascade be halted?

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12 December 2020

Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration.

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12 December 2020

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

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12 December 2020

Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.

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12 December 2020

Antioxidant vitamin intake and risk of Alzheimer disease

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12 December 2020

Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation

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12 December 2020

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

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12 December 2020

Neurotrophin signaling through the p75 neurotrophin receptor

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12 December 2020

Tau as a drug target in Alzheimer's disease.

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12 December 2020

Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan).

1 reference

12 December 2020

Neurotrophin small-molecule mimetics

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12 December 2020

Antioxidant strategies for Alzheimer's disease

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12 December 2020

Local neuroinflammation and the progression of Alzheimer's disease

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12 December 2020

Mitochondria, free radicals, and neurodegeneration

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12 December 2020

H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK.

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12 December 2020

JNK activation is associated with intracellular beta-amyloid accumulation

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12 December 2020

Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.

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12 December 2020

Increase of brain oxidative stress in mild cognitive impairment: a possible predictor of Alzheimer disease

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12 December 2020

Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells

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12 December 2020

Amyloid peptide toxicity and microtubule-stabilizing drugs.

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12 December 2020

Alzheimer's disease and oxygen radicals: new insights

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12 December 2020

Neuroprotective properties of valproate: potential benefit for AD and tauopathies

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12 December 2020

A new concept in the pharmacology of neuroprotection

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12 December 2020

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

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12 December 2020

Glumate receptor dysfunction and Alzheimer's disease.

1 reference

12 December 2020

Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway

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12 December 2020

Nerve growth factor signaling, neuroprotection, and neural repair

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12 December 2020

Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).

1 reference

12 December 2020

Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40).

1 reference

12 December 2020

A 52-week study of the efficacy of rivastigmine in patients with mild to moderately severe Alzheimer's disease.

1 reference

12 December 2020

Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies

1 reference

12 December 2020

The role of tau in Alzheimer's disease

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12 December 2020

Analysis of outcome in retrieved dropout patients in a rivastigmine vs placebo, 26-week, Alzheimer disease trial

1 reference

12 December 2020

Memantine in moderate-to-severe Alzheimer's disease

1 reference

12 December 2020

Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF.

1 reference

12 December 2020

Ultrastructural localization of full-length trkB immunoreactivity in rat hippocampus suggests multiple roles in modulating activity-dependent synaptic plasticity.

1 reference

12 December 2020

Calcium and excitotoxic neuronal injury.

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12 December 2020

Neurotrophins and their receptors: a convergence point for many signalling pathways

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12 December 2020

Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain

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12 December 2020

AF150(S) and AF267B: M1 muscarinic agonists as innovative therapies for Alzheimer's disease

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12 December 2020

The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.

1 reference

12 December 2020

The glutamatergic system and Alzheimer's disease: therapeutic implications

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12 December 2020

Apoptosis in the nervous system

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12 December 2020

Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons

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12 December 2020

Death and survival of neuronal cells exposed to Alzheimer's insults

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12 December 2020

Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus

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12 December 2020

Galantamine, a cholinesterase inhibitor that allosterically modulates nicotinic receptors: effects on the course of Alzheimer's disease

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12 December 2020

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation

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12 December 2020

Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease

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12 December 2020

Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion

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12 December 2020

Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity.

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12 December 2020

Rapid suppression of free radical formation by nerve growth factor involves the mitogen-activated protein kinase pathway

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12 December 2020

Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism.

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12 December 2020

Modulation of sensory inputs and ectopic presence of Schwann cells depend upon the route and duration of nerve growth factor administration

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12 December 2020

Identifiers

DOI

10.1602/NEURORX.1.1.117

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717012 AND SRC:MED&resulttype=core&format=json

8 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15717012 AND SRC:MED&resulttype=core&format=json

8 January 2020

PubMed publication ID

15717012

1 reference