Lysosomes contribute to anomalous pharmacokinetic behavior of melanocortin-4 receptor agonists (Q79991809)

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27 December 2019

title

Lysosomes contribute to anomalous pharmacokinetic behavior of melanocortin-4 receptor agonists (English)

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Yuping Gong

1

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Zhiyang Zhao

2

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Donavon J McConn

3

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Beth Beaudet

4

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Melanie Tallman

5

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Jason D Speake

6

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Diane M Ignar

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Jeffrey P Krise

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publication date

21 March 2007

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27 December 2019

published in

Pharmaceutical Research

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volume

24

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issue

6

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page(s)

1138-1144

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Commentary. Lysosomotropic agents

27 December 2019

cites work

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12 December 2020

Expulsion of small molecules in vesicles shed by cancer cells: association with gene expression and chemosensitivity profiles.

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12 December 2020

Weak base permeability characteristics influence the intracellular sequestration site in the multidrug-resistant human leukemic cell line HL-60.

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Separate Roles for the Golgi Apparatus and Lysosomes in the Sequestration of Drugs in the Multidrug-resistant Human Leukemic Cell Line HL-60

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A chemical strategy to manipulate the intracellular localization of drugs in resistant cancer cells

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12 December 2020

A cell fractionation approach for the quantitative analysis of subcellular drug disposition

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12 December 2020

Influence of lipophilicity and lysosomal accumulation on tissue distribution kinetics of basic drugs: a physiologically based pharmacokinetic model

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12 December 2020

Contribution of lysosomal trapping to the total tissue uptake of psychotropic drugs

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12 December 2020

Intracellular localization and trafficking of fluorescein-labeled cisplatin in human ovarian carcinoma cells.

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12 December 2020

A novel assay reveals that weakly basic model compounds concentrate in lysosomes to an extent greater than pH-partitioning theory would predict

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12 December 2020

A new approach for enhancing differential selectivity of drugs to cancer cells

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12 December 2020

Gentamicin traffics retrograde through the secretory pathway and is released in the cytosol via the endoplasmic reticulum

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12 December 2020

Uptake of imipramine in rat liver lysosomes in vitro and its inhibition by basic drugs

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12 December 2020

In bafilomycin A1-resistant cells, bafilomycin A1 raised lysosomal pH and both prodigiosins and concanamycin A inhibited growth through apoptosis

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12 December 2020

Defective pH regulation of acidic compartments in human breast cancer cells (MCF-7) is normalized in adriamycin-resistant cells (MCF-7adr).

1 reference

12 December 2020

10.1007/S11095-007-9239-Y

Identifiers

DOI

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