Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently (Q79954598)

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27 December 2019

title

Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently (English)

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27 December 2019

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Farid NA

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Payne CD

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Small DS

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Winters KJ

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Ernest CS 2nd

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Brandt JT

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Darstein C

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Jakubowski JA

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Salazar DE

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publication date

14 March 2007

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Clinical Pharmacology & Therapeutics

27 December 2019

published in

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volume

81

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issue

5

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27 December 2019

page(s)

735-741

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Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270.

27 December 2019

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