Chiral inversion of RS-8359: a selective and reversible MAO-A inhibitor via oxido-reduction of keto-alcohol (Q79846760)

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26 December 2019

title

Chiral inversion of RS-8359: a selective and reversible MAO-A inhibitor via oxido-reduction of keto-alcohol (English)

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26 December 2019

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Kunio Itoh

1

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26 December 2019

Kouichi Hoshino

2

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26 December 2019

Asuka Endo

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26 December 2019

Tasuku Asakawa

4

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26 December 2019

Kazumi Yamakami

5

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26 December 2019

Chisa Noji

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26 December 2019

Toshiyuki Kosaka

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26 December 2019

Yorihisa Tanaka

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26 December 2019

publication date

1 September 2006

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26 December 2019

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volume

18

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26 December 2019

issue

9

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26 December 2019

page(s)

698-706

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Comparative studies of the effects of RS-8359 and safrazine on monoamine oxidase in-vitro and in-vivo in mouse brain

26 December 2019

cites work

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7 January 2021

Deamination of norepinephrine, dopamine, and serotonin by type A monoamine oxidase in discrete regions of the rat brain and inhibition by RS-8359

1 reference

7 January 2021

Changes in monoamine levels in mouse brain elicited by forced-swimming stress, and the protective effect of a new monoamine oxidase inhibitor, RS-8359

1 reference

7 January 2021

The comparative effects of single and multiple doses of RS-8359, moclobemide and placebo on psychomotor function in healthy subjects

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7 January 2021

The effects of RS-8359 on cardiovascular function in healthy subjects and depressed patients

1 reference

7 January 2021

Stereoselective pharmacokinetics of RS-8359, a selective and reversible inhibitor of A-type monoamine oxidase, in rats, mice, dogs, and monkeys

1 reference

7 January 2021

Stereoselective pharmacokinetics of RS-8359, a selective and reversible MAO-A inhibitor, by species-dependent drug-metabolizing enzymes

1 reference

7 January 2021

Stereospecific oxidation of the (S)-enantiomer of RS-8359, a selective and reversible monoamine oxidase A (MAO-A) inhibitor, by aldehyde oxidase

1 reference

7 January 2021

Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry

1 reference

7 January 2021

Inhibition of a major NAD(P)-linked oxidoreductase from rat liver cytosol by steroidal and nonsteroidal anti-inflammatory agents and by prostaglandins

1 reference

7 January 2021

Purification and properties of a 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol and its inhibition by anti-inflammatory drugs

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7 January 2021

Purification and characterization of NADP -dependent 3 alpha-hydroxysteroid dehydrogenase from mouse liver cytosol

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7 January 2021

The kinetic mechanism catalysed by homogeneous rat liver 3 alpha-hydroxysteroid dehydrogenase. Evidence for binary and ternary dead-end complexes containing non-steroidal anti-inflammatory drugs

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7 January 2021

Inhibition of bovine brain aldehyde reductase by anticonvulsant compounds in vitro

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7 January 2021

Kinetics and mechanism of action of aldehyde reductase from pig kidney

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7 January 2021

The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences

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7 January 2021

Pharmacokinetics of enantiomers of chiral non-steroidal anti-inflammatory drugs

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7 January 2021

The metabolic chiral inversion of 2-arylpropionic acids—a novel route with pharmacological consequences

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7 January 2021

Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (—)-isomer

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7 January 2021

Isomeric inversion of ibuprofen (R)-enantiomer in humans

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7 January 2021

Pharmacokinetics of ibuprofen enantiomers in humans following oral administration of tablets with different absorption rates

1 reference

7 January 2021

Stereoselective inversion of (R)-fenoprofen to (S)-fenoprofen in humans

1 reference

7 January 2021

High-performance liquid chromatographic determination of stereoselective disposition of carprofen in humans

1 reference

7 January 2021

Stereoselective pharmacokinetics of flurbiprofen in humans and rats

1 reference

7 January 2021

Pharmacokinetics of ketoprofen enantiomers in healthy subjects following single and multiple doses

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7 January 2021

A comparison between stereospecificity of oracin reduction and stereoselectivity of oxidation of 11-dihydrooracin enantiomersin vitro in rat and guinea pig

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7 January 2021

Chiral aspects of metabolism of antiinflammatory drug flobufen in human hepatocytes

1 reference

7 January 2021

Chiral assay methods for lifibrol and metabolites in plasma and the observation of unidirectional chiral inversion following administration of the enantiomers to dogs

1 reference

7 January 2021

Chiral inversion of drug: role of intestinal bacteria in the stereoselective sulphoxide reduction of flosequinan

1 reference

7 January 2021

Stereoselective pharmacokinetics and interconversions of flosequinan enantiomers containing chiral sulphoxide in rat

1 reference

7 January 2021

Rat liver 3 alpha-hydroxysteroid dehydrogenase.

1 reference

7 January 2021

Reduction of prostaglandin D2 to 9 alpha,11 beta-prostaglandin F2 by a human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isozyme

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7 January 2021

Xenobiotic carbonyl reduction and physiological steroid oxidoreduction. The pluripotency of several hydroxysteroid dehydrogenases

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7 January 2021

A new nomenclature for the aldo-keto reductase superfamily

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7 January 2021

Functional expression, purification, and characterization of 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni

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7 January 2021

Identifiers

DOI

10.1002/CHIR.20309

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26 December 2019

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