Interleukin-5 and eosinophils as therapeutic targets for asthma (Q77856796)

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8 December 2019

title

Interleukin-5 and eosinophils as therapeutic targets for asthma (English)

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8 December 2019

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7

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8 December 2019

author name string

Paul S Foster

1

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8 December 2019

Simon P Hogan

2

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8 December 2019

Ming Yang

3

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8 December 2019

Joerg Mattes

4

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8 December 2019

Ian G Young

5

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8 December 2019

Klaus I Matthaei

6

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8 December 2019

Surendran Mahalingam

8

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8 December 2019

Dianne C Webb

9

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8 December 2019

publication date

1 April 2002

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Trends in Molecular Medicine

8 December 2019

published in

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8 December 2019

volume

8

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8 December 2019

issue

4

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8 December 2019

page(s)

162-167

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Immunological aspects of allergic asthma

8 December 2019

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Increases in activated T lymphocytes, eosinophils, and cytokine mRNA expression for interleukin-5 and granulocyte/macrophage colony-stimulating factor in bronchial biopsies after allergen inhalation challenge in atopic asthmatics

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Eosinophilic inflammation is associated with elevation of interleukin-5 in the airways of patients with spontaneous symptomatic asthma

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Allergen challenge in asthma: association of eosinophils and lymphocytes with interleukin-5

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The immediate and late allergic response to segmental bronchopulmonary provocation in asthma

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Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma

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Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization

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Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

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Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma

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Activation of CD4 T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma

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Human eosinophil major basic protein causes hyperreactivity of respiratory smooth muscle. Role of the epithelium

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7 January 2021

The eosinophil as a mediator of damage to respiratory epithelium: a model for bronchial hyperreactivity

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7 January 2021

The role of eosinophils in the pathogenesis of asthma

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7 January 2021

The eosinophil and bronchial asthma: current understanding

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Stimulus-dependent differences in superoxide anion generation by normal human eosinophils and neutrophils

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The inflammatory response in asthma exacerbation: changes in circulating eosinophils, basophils and their progenitors

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Allergen-induced asthmatic responses. Relationship between increases in airway responsiveness and increases in circulating eosinophils, basophils, and their progenitors

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Changes in Bone Marrow Inflammatory Cell Progenitors after Inhaled Allergen in Asthmatic Subjects

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7 January 2021

Allergen-induced increase in airway responsiveness, airway eosinophilia, and bone-marrow eosinophil progenitors in mice

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7 January 2021

Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34 cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation

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7 January 2021

Allergen Challenge Increases Cell Traffic between Bone Marrow and Lung

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7 January 2021

Bone marrow contribution to eosinophilic inflammation

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7 January 2021

Molecular and cellular biology of eosinophil differentiation factor (interleukin-5) and its effects on human and mouse B cells

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7 January 2021

Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice

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7 January 2021

Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice

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7 January 2021

Development of eosinophilic airway inflammation and airway hyperresponsiveness requires interleukin-5 but not immunoglobulin E or B lymphocytes

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7 January 2021

Effect of murine recombinant interleukin-5 on bronchial reactivity in guinea-pigs

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7 January 2021

Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma

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7 January 2021

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

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7 January 2021

The trials and tribulations of IL-5, eosinophils, and allergic asthma

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7 January 2021

Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity

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7 January 2021

Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5)

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7 January 2021

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7 January 2021

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7 January 2021

IL-5-deficient mice have a developmental defect in CD5 B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses.

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7 January 2021

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7 January 2021

Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice

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7 January 2021

Elemental signals regulating eosinophil accumulation in the lung.

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7 January 2021

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

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7 January 2021

Effect of anti-IL-5 monoclonal antibody on allergic bronchial eosinophilia and airway hyperresponsiveness in mice

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7 January 2021

Airway eosinophilia is not a requirement for allergen-induced airway hyperresponsiveness

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7 January 2021

The allergen-induced airway hyperresponsiveness in a human-mouse chimera model of asthma is T cell and IL-4 and IL-5 dependent

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7 January 2021

Inhibition of antigen-induced eosinophilia and late phase airway hyperresponsiveness by an IL-5 antisense oligonucleotide in mouse models of asthma

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7 January 2021

Therapeutic efficacy of an anti-IL-5 monoclonal antibody delivered into the respiratory tract in a murine model of asthma

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7 January 2021

Eosinophilia, parasite burden and lung damage in Toxocara canis infection in C57Bl/6 mice genetically deficient in IL-5.

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7 January 2021

A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation

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7 January 2021

Murine model of chronic human asthma.

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7 January 2021

Dissociation of inflammatory and epithelial responses in a murine model of chronic asthma

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7 January 2021

An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen

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7 January 2021

Cellular and molecular regulation of eosinophil trafficking to the lung

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7 January 2021

10.1016/S1471-4914(02)02302-X

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11927273 AND SRC:MED&resulttype=core&format=json

8 December 2019

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