Inhibition and induction of cytochrome P450 and the clinical implications (Q77634762)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9839089 AND SRC:MED&resulttype=core&format=json

7 December 2019

review article

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title

Inhibition and induction of cytochrome P450 and the clinical implications (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9839089 AND SRC:MED&resulttype=core&format=json

7 December 2019

author name string

J H Lin

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9839089 AND SRC:MED&resulttype=core&format=json

7 December 2019

A Y Lu

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9839089 AND SRC:MED&resulttype=core&format=json

7 December 2019

publication date

1 November 1998

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Clinical Pharmacokinetics

7 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9839089 AND SRC:MED&resulttype=core&format=json

7 December 2019

volume

35

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9839089 AND SRC:MED&resulttype=core&format=json

7 December 2019

issue

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9839089 AND SRC:MED&resulttype=core&format=json

7 December 2019

page(s)

361-390

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Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.

7 December 2019

cites work

1 reference

12 December 2020

Identification of the rabbit and human cytochromes P-450IIIA as the major enzymes involved in the N-demethylation of diltiazem

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12 December 2020

Further insight into the stereoselective interaction between warfarin and cimetidine in man

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12 December 2020

Interethnic difference in omeprazole's inhibition of diazepam metabolism*

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12 December 2020

Structure-activity relationships in the effects of 1-alkylimidazoles on microsomal oxidation in vitro and in vivo

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12 December 2020

Mechanism of the cardiotoxic actions of terfenadine

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12 December 2020

Time-dependent kinetics. V: Time course of drug levels during enzyme induction (one-compartment model)

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12 December 2020

Increase of cytochrome P450IA2 activity by omeprazole: evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin

1 reference

12 December 2020

Diltiazem enhances the effects of triazolam by inhibiting its metabolism

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12 December 2020

Formation and binding of carbanions by cytochrome P-450 of liver microsomes.

1 reference

12 December 2020

Induction of cytochrome P450IA genes (CYP1A) by omeprazole in the human alimentary tract

1 reference

12 December 2020

Selective inhibition of rat hepatic microsomal cytochrome P-450. I. Effect of the in vivo administration of cimetidine

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12 December 2020

In vitro prediction of the terfenadine-ketoconazole pharmacokinetic interaction

1 reference

12 December 2020

Time-Dependent Kinetics VI: Direct Relationship Between Equations for Drug Levels During Induction and Those Involving Constant Clearance

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12 December 2020

The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene

1 reference

12 December 2020

Biotransformation of lovastatin. IV. Identification of cytochrome P450 3A proteins as the major enzymes responsible for the oxidative metabolism of lovastatin in rat and human liver microsomes

1 reference

12 December 2020

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

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12 December 2020

2,3,7,8-Tetrachlorodibenzo-p-dioxin: Potent anticarcinogenic activity in CD-1 mice

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12 December 2020

Selective inhibitory interactions of alkoxymethylenedioxybenzenes towards mono-oxygenase activity in rat-hepatic microsomes.

1 reference

12 December 2020

Enzyme induction and beta-adrenergic receptor blocking drugs

1 reference

12 December 2020

Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily

1 reference

12 December 2020

Structural basis of selective cytochrome P450 inhibition

1 reference

12 December 2020

Polymorphic O-demethylation of codeine

1 reference

12 December 2020

Formation of an inactive cytochrome P-450 Fe(II)-metabolite complex after administration of troleandomycin in humans

1 reference

12 December 2020

Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles

1 reference

12 December 2020

Selective inhibition of rat hepatic microsomal cytochrome P-450. II. Effect of the in vitro administration of cimetidine

1 reference

12 December 2020

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

1 reference

12 December 2020

Warfarin-fluconazole. I. Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies

1 reference

12 December 2020

Stabilization of cytochrome P450j messenger ribonucleic acid in the diabetic rat

1 reference

12 December 2020

Mechanistic aspects of the inhibition of microsomal drug oxidation by primaquine.

1 reference

12 December 2020

Inhibitors of adrenal steroid biosynthesis

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12 December 2020

Drug interactions with cimetidine

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12 December 2020

The effect of cimetidine on in vitro and in vivo microsomal drug metabolism in the rat

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12 December 2020

Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450.

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12 December 2020

CYP1A1: friend or foe?

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12 December 2020

Inactivation of cytochrome P-450 and production of N-alkylated porphyrins caused in isolated hepatocytes by substituted dihydropyridines. Structural requirements for loss of haem and alkylation of the pyrrole nitrogen atom

1 reference

12 December 2020

Covalent modification of lysine during the suicide inactivation of rat liver cytochrome P-450 by chloramphenicol

1 reference

12 December 2020

Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis

1 reference

12 December 2020

Induction of polymorphic 4'-hydroxylation of S-mephenytoin by rifampicin

1 reference

12 December 2020

Genetically determined steady-state interaction between encainide and quinidine in patients with arrhythmias

1 reference

12 December 2020

Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine

1 reference

12 December 2020

Interaction of sodium warfarin and rifampin. Studies in man.

1 reference

12 December 2020

Stereo- and regioselective N- and S-oxidation of tertiary amines and sulfides in the presence of adult human liver microsomes

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12 December 2020

Effects of age and cigarette smoking on propranolol disposition

1 reference

12 December 2020

Further studies on the dissociation of the isosafrole metabolite-cytochrome p-450 complex

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12 December 2020

Self-induction by erythromycin of its own transformation into a metabolite forming an inactive complex with reduced cytochrome P-450.

1 reference

12 December 2020

The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study

1 reference

12 December 2020

Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.

1 reference

12 December 2020

The molecular basis of genetic polymorphisms of drug metabolism.

1 reference

12 December 2020

In vitro approaches to predicting drug interactions in vivo.

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12 December 2020

Differential inhibition of individual human liver cytochromes P-450 by cimetidine

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12 December 2020

Effect of omeprazole treatment on diazepam plasma levels in slow versus normal rapid metabolizers of omeprazole

1 reference

12 December 2020

Metabolism of diazepam in vitro by human liver. Independent variability of N-demethylation and C3-hydroxylation

1 reference

12 December 2020

Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes

1 reference

12 December 2020

Human immunodeficiency virus protease inhibitors. From drug design to clinical studies

1 reference

12 December 2020

Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats

1 reference

12 December 2020

Pharmacokinetic interactions between antiepileptic drugs. Clinical considerations

1 reference

12 December 2020

Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin

1 reference

12 December 2020

On the mechanism of the inactivation of the major phenobarbital-inducible isozyme of rat liver cytochrome P-450 by chloramphenicol.

1 reference

12 December 2020

Effect of mefloquine on hepatic drug metabolism in the rat: comparative study with primaquine

1 reference

12 December 2020

Differential haemin-mediated restoration of cytochrome P-450 N-demethylases after inactivation by allylisopropylacetamide

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12 December 2020

Pharmacokinetic interactions of cimetidine 1987.

1 reference

12 December 2020

Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture

1 reference

12 December 2020

Rifampicin induction of lidocaine metabolism in cultured human hepatocytes

1 reference

12 December 2020

Mechanism of the inhibitory action of isoniazid on microsomal drug metabolism

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12 December 2020

Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: In vitro and in vivo comparison and calculation of in vivo inhibition constants*

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12 December 2020

Generation of carbon monoxide during the microsomal metabolism of methylenedioxyphenyl compounds

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12 December 2020

Clinical implications of enzyme induction

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12 December 2020

Influence of extracellular matrix overlay on phenobarbital-mediated induction of CYP2B1, 2B2, and 3A1 genes in primary adult rat hepatocyte culture

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12 December 2020

Phenobarbital and related compounds: approaches to interspecies extrapolation

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12 December 2020

Correlation between in vitro and in vivo drug metabolism rate: oxidation of ethoxybenzamide in rat

1 reference

12 December 2020

The use of other drugs to allow a lower dosage of cyclosporin to be used. Therapeutic and pharmacoeconomic considerations

1 reference

12 December 2020

Dose of midazolam should be reduced during diltiazem and verapamil treatments

1 reference

12 December 2020

The biotransformation of the ergot derivative CQA 206-291 in human, dog, and rat liver slice cultures and prediction of in vivo plasma clearance

1 reference

12 December 2020

Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese

1 reference

12 December 2020

Influence of pyridine and some pyridine derivatives on spectral properties of reduced microsomes and on microsomal drug metabolizing activity

1 reference

12 December 2020

Commentary: a physiological approach to hepatic drug clearance

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12 December 2020

Age-dependent stereoselective increase in the oral clearance of hexobarbitone isomers caused by rifampicin

1 reference

12 December 2020

Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes

1 reference

12 December 2020

Cytochrome P450 monooxygenases and interactions of psychotropic drugs: a five-year update

1 reference

12 December 2020

Oxidative metabolism of spironolactone: evidence for the involvement of electrophilic thiosteroid species in drug-mediated destruction of rat hepatic cytochrome P450.

1 reference

12 December 2020

Diphenylhydantoin intoxication. A complication of isoniazid therapy

1 reference

12 December 2020

Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner

1 reference

12 December 2020

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase

1 reference

12 December 2020

Clinically significant drug interactions with cyclosporin. An update

1 reference

12 December 2020

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1 reference

12 December 2020

Syncope and cardiac arrhythmia due to an interaction between itraconazole and terfenadine.

1 reference

12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1 reference

12 December 2020

Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: relation to pharmacokinetic interactions in vivo

1 reference

12 December 2020

Catalytic selectivity of human cytochrome P450 enzymes: relevance to drug metabolism and toxicity

1 reference

12 December 2020

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis

1 reference

12 December 2020

Inhibition of desipramine hydroxylation in vitro by serotonin-reuptake-inhibitor antidepressants, and by quinidine and ketoconazole: a model system to predict drug interactions in vivo

1 reference

12 December 2020

The potentiation of warfarin anticoagulation by amiodarone

1 reference

12 December 2020

Clearance approaches in pharmacology.

1 reference

12 December 2020

A class of strong inhibitors of microsomal monooxygenases: The elupticines

1 reference

12 December 2020

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily

1 reference

12 December 2020

Dual effects of macrolide antibiotics on rat liver cytochrome P-450. Induction and formation of metabolite-complexes: a structure-activity relationship

1 reference

12 December 2020

Induction and autoinduction properties of rifamycin derivatives: a review of animal and human studies

1 reference

12 December 2020

Effect of albumin on the estimation, in vitro, of phenytoin Vmax and Km values: implications for clinical correlation

1 reference

12 December 2020

Understanding consequences of concurrent therapies

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12 December 2020

Human cytochromes P450: problems and prospects

1 reference

12 December 2020

Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability

1 reference

12 December 2020

Impaired enzyme induction by rifampicin in the elderly

1 reference

12 December 2020

Prediction of in vivo disposition from in vitro systems: clearance of phenytoin and tolbutamide using rat hepatic microsomal and hepatocyte data

1 reference

12 December 2020

Effects of erythromycin on hepatic drug-metabolizing enzymes in humans

1 reference

12 December 2020

Antidepressant drug interactions and the cytochrome P450 system: a critical appraisal.

1 reference

12 December 2020

Induction of drug-metabolizing enzymes by xenobiotics

1 reference

12 December 2020

Effect of product inhibition on elimination kinetics of ethoxybenzamide in rabbits. Analysis by physiological pharmacokinetic model

1 reference

12 December 2020

Acute rejection and massive cyclosporine requirements in heart transplant recipients treated with rifampin

1 reference

12 December 2020

Torsades de pointes occurring in association with terfenadine use

1 reference

12 December 2020

Complexation of cytochrome P-450 isozymes in hepatic microsomes from SKF 525-A-induced rats

1 reference

12 December 2020

Self-induction by oleandomycin of its own transformation into a metabolite forming an inactive complex with reduced cytochrome P-450. Comparison with troleandomycin

1 reference

12 December 2020

Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation

1 reference

12 December 2020

The complex interaction between ethanol and acetaminophen

1 reference

12 December 2020

Enzymatic oxidation of xenobiotic chemicals

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12 December 2020

Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

1 reference

12 December 2020

Differences between white subjects and Chinese subjects in the in vivo inhibition of cytochrome P450s 2C19, 2D6, and 3A by omeprazole

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12 December 2020

The effect of rifampicin on norethisterone pharmacokinetics

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12 December 2020

Reduced induction of drug metabolism in the elderly

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12 December 2020

Influence of pentobarbital on effect and plasma levels of alprenolol and 4-hydroxy-alprenolol

1 reference

12 December 2020

Interaction of methylenedioxyphenyl (1,3-benzodioxole) compounds with enzymes and their effects on mammals.

1 reference

12 December 2020

Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples

1 reference

12 December 2020

In vitro effects of quinoline derivatives on cytochrome P-450 and aminopyrine N-demethylase activity in rat hepatic microsomes

1 reference

12 December 2020

The mechanism of the interaction between amiodarone and warfarin in humans

1 reference

12 December 2020

Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor.

1 reference

12 December 2020

Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450

1 reference

12 December 2020

Mechanism of induction of cytochrome P-450ac (P-450j) in chemically induced and spontaneously diabetic rats

1 reference

12 December 2020

Interaction between cyclosporin and rifampicin

1 reference

12 December 2020

Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization

1 reference

12 December 2020

Ketoconazole to reduce the need for cyclosporine after cardiac transplantation

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic properties of histamine H2-receptor antagonists. Relationship between intrinsic potency and effective plasma concentrations

1 reference

12 December 2020

Inactivation of multiple hepatic cytochrome P-450 isozymes in rats by allylisopropylacetamide: mechanistic implications.

1 reference

12 December 2020

Physiological pharmacokinetics of ethoxybenzamide based on biochemical data obtained in vitro as well as on physiological data

1 reference

12 December 2020

Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid

1 reference

12 December 2020

Kinetics of drug metabolism in rat liver slices. II. Comparison of clearance by liver slices and freshly isolated hepatocytes.

1 reference

12 December 2020

Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor.

1 reference

12 December 2020

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1 reference

12 December 2020

Inhibition of oxidative drug metabolism by orphenadrine: in vitro and in vivo evidence for isozyme-specific complexation of cytochrome P-450 and inhibition kinetics

1 reference

12 December 2020

Steric factors in the inhibitory interaction of imidazoles with microsomal enzymes

1 reference

12 December 2020

Antipyrine metabolite kinetics in healthy human volunteers during multiple dosing of phenytoin and carbamazepine

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12 December 2020

Cyclosporin A metabolism in human liver, kidney, and intestine slices. Comparison to rat and dog slices and human cell lines

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12 December 2020

An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials.

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12 December 2020

Time-Dependent Kinetics IV: Pharmacokinetic Theory of Enzyme Induction

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12 December 2020

Development of a simple incubation system for metabolism studies with precision-cut liver slices

1 reference

12 December 2020

MECHANISM OF INHIBITION OF ADRENAL STEROID 11BETA-HYDROXYLASE BY METHOPYRAPONE (METOPIRONE)

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12 December 2020

Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors.

1 reference

12 December 2020

Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences

1 reference

12 December 2020

Warfarin. Stereochemical aspects of its metabolism and the interaction with phenylbutazone

1 reference

12 December 2020

Particular ability of cytochromes P450 3A to form inhibitory P450-iron-metabolite complexes upon metabolic oxidation of aminodrugs

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12 December 2020

Interaction of Isoniazid and Warfarin

1 reference

12 December 2020

SKF 525-A inhibition, induction, and 452-nm complex formation

1 reference

12 December 2020

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

1 reference

12 December 2020

Time- and dose-dependent pharmacokinetics of L-754,394, an HIV protease inhibitor, in rats, dogs and monkeys

1 reference

12 December 2020

Effect of rifampicin.treatment on the metabolism of oestradiol and 17?-ethinyloestradiol by human liver microsomes

1 reference

12 December 2020

Specific and dose-dependent enzyme induction by omeprazole in human beings.

1 reference

12 December 2020

Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid

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12 December 2020

Mechanism-based inactivation of cytochrome P450 2B1 by 2-ethynylnaphthalene: identification of an active-site peptide

1 reference

12 December 2020