Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension (Q77116617)

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3 December 2019

title

Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension (English)

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3 December 2019

author name string

I Böhm

1

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3 December 2019

I E Holzbaur

2

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3 December 2019

U Hanefeld

3

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3 December 2019

J Cortés

4

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3 December 2019

J Staunton

5

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3 December 2019

P F Leadlay

6

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publication date

1 August 1998

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3 December 2019

published in

Chemistry and Biology

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3 December 2019

volume

5

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issue

8

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3 December 2019

page(s)

407-412

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An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

3 December 2019

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Modular organization of genes required for complex polyketide biosynthesis

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6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme

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Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence

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Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

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Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase

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Production of a novel polyketide through the construction of a hybrid polyketide synthase.

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Identification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis

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Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea

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Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage

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Polyketide synthesis in vitro on a modular polyketide synthase

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Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases

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Engineered Biosynthesis of Structurally Diverse Tetraketides by a Trimodular Polyketide Synthase

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A hybrid modular polyketide synthase obtained by domain swapping

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Engineering broader specificity into an antibiotic-producing polyketide synthase

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7 January 2021

Engineered intermodular and intramodular polyketide synthase fusions

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7 January 2021

Combinatorial approaches to polyketide biosynthesis

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7 January 2021

Evidence for a double-helical structure for modular polyketide synthases.

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7 January 2021

Fatty acid synthase, a proficient multifunctional enzyme

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7 January 2021

Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase

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7 January 2021

Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase

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7 January 2021

Mapping of functional interactions between domains of the animal fatty acid synthase by mutant complementation in vitro

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7 January 2021

The Molecular Basis of Celmer's Rules: The Stereochemistry of the Condensation Step in Chain Extension on the Erythromycin Polyketide Synthase†

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Construction of new vectors for high-level expression in actinomycetes

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7 January 2021

Biosynthetic incorporation of labeled tetraketide intermediates into dehydrocurvularin, a phytotoxin from Alternaria cinerariae, with assistance of .beta.-oxidation inhibitors

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7 January 2021

The Thioesterase of the Erythromycin-Producing Polyketide Synthase: Influence of Acyl Chain Structure on the Mode of Release of Substrate Analogues from the Acyl Enzyme Intermediates

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7 January 2021

MACROLIDE STEREOCHEMISTRY. 3. A CONFIGURATIONAL MODEL FOR MACROLIDE ANTIBIOTICS

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7 January 2021

Stereospecific acyl transfers on the erythromycin-producing polyketide synthase

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7 January 2021

10.1016/S1074-5521(98)90157-0

Identifiers

DOI

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3 December 2019

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