Opinion: Searching for the elusive targets of farnesyltransferase inhibitors (Q75312802)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737124 AND SRC:MED&resulttype=core&format=json

17 November 2019

review article

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title

Opinion: Searching for the elusive targets of farnesyltransferase inhibitors (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737124 AND SRC:MED&resulttype=core&format=json

17 November 2019

author name string

Saïd M Sebti

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737124 AND SRC:MED&resulttype=core&format=json

17 November 2019

Channing J Der

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737124 AND SRC:MED&resulttype=core&format=json

17 November 2019

publication date

1 December 2003

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737124 AND SRC:MED&resulttype=core&format=json

17 November 2019

published in

Nature Reviews Cancer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737124 AND SRC:MED&resulttype=core&format=json

17 November 2019

volume

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737124 AND SRC:MED&resulttype=core&format=json

17 November 2019

issue

12

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17 November 2019

page(s)

945-951

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737124 AND SRC:MED&resulttype=core&format=json

Understanding Ras: 'it ain't over 'til it's over'.

17 November 2019

cites work

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The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

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Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules

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Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells

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The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

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Geranylgeranylated RhoB is sufficient to mediate tissue-specific suppression of Akt kinase activity by farnesyltransferase inhibitors

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Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

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High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors

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Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB

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RhoB prenylation is driven by the three carboxyl-terminal amino acids of the protein: evidenced in vivo by an anti-farnesyl cysteine antibody

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The expression of rho proteins decreases with human brain tumor progression: potential tumor markers

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Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant

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