CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2 (Q74660381)

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12 November 2019

title

CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2 (English)

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12 November 2019

author name string

Thomas R Malek

1

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12 November 2019

Aixin Yu

2

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12 November 2019

Vladimir Vincek

3

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12 November 2019

Paul Scibelli

4

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12 November 2019

Lin Kong

5

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12 November 2019

publication date

1 August 2002

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12 November 2019

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12 November 2019

volume

17

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12 November 2019

issue

2

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12 November 2019

page(s)

167-178

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CD25 CD4 T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10

12 November 2019

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Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors

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Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cells

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Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency

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Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

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Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4 T cells

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Regulatory T cells: key controllers of immunologic self-tolerance

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B7/CD28 costimulation is essential for the homeostasis of the CD4 CD25 immunoregulatory T cells that control autoimmune diabetes

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7 January 2021

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

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7 January 2021

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CD25 is a marker for CD4 thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25 and CD25- subpopulations.

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Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

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Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 receptor beta chain-deficient mice

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Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo

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7 January 2021

Suppressor effector function of CD4 CD25 immunoregulatory T cells is antigen nonspecific

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7 January 2021

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7 January 2021

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

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Control of T cell hyperactivation in IL-2-deficient mice by CD4( )CD25(-) and CD4( )CD25( ) T cells: evidence for two distinct regulatory mechanisms

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Identifiers

DOI

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12 November 2019

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