Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1 (Q74241797)

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scientific article published on 01 September 2000

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English	Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1	scientific article published on 01 September 2000

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10964951 AND SRC:MED&resulttype=core&format=json

9 November 2019

Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1 (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10964951 AND SRC:MED&resulttype=core&format=json

9 November 2019

author name string

I Dewachter

1

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9 November 2019

J Van Dorpe

2

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9 November 2019

L Smeijers

3

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9 November 2019

M Gilis

4

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9 November 2019

C Kuipéri

5

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9 November 2019

I Laenen

6

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9 November 2019

N Caluwaerts

7

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9 November 2019

D Moechars

8

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9 November 2019

F Checler

9

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9 November 2019

H Vanderstichele

10

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9 November 2019

F Van Leuven

11

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9 November 2019

publication date

1 September 2000

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9 November 2019

Journal of Neuroscience

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9 November 2019

20

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9 November 2019

17

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9 November 2019

6452-6458

1 reference

Europe PubMed Central

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9 November 2019

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiop

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does Alzheimer disease tilt the scales of amyloid degradation versus accumulation?

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant and native human beta-amyloid precursor proteins in transgenic mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mice expressing an alpha-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In search of gamma-secretase: presenilin at the cutting edge

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggressive behaviour in transgenic mice expressing APP is alleviated by serotonergic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/10964951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.20-17-06452.2000

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10964951 AND SRC:MED&resulttype=core&format=json

9 November 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10964951 AND SRC:MED&resulttype=core&format=json

9 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10964951 AND SRC:MED&resulttype=core&format=json

9 November 2019

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