Impact of age on hypermutation of immunoglobulin variable genes in humans (Q73827681)

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7 November 2019

title

Impact of age on hypermutation of immunoglobulin variable genes in humans (English)

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7 November 2019

author name string

K Rosner

1

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7 November 2019

D B Winter

2

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7 November 2019

C Kasmer

3

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7 November 2019

G L Skovgaard

4

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7 November 2019

R E Tarone

5

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7 November 2019

V A Bohr

6

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7 November 2019

P J Gearhart

7

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7 November 2019

publication date

1 March 2001

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7 November 2019

number of pages

14

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Journal of Clinical Immunology

inferred from page(s)

published in

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7 November 2019

volume

21

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7 November 2019

issue

2

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7 November 2019

page(s)

102-115

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Dual enigma of somatic hypermutation of immunoglobulin variable genes: targeting and mechanism

7 November 2019

cites work

1 reference

12 December 2020

High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire

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12 December 2020

Increased Hypermutation at G and C Nucleotides in Immunoglobulin Variable Genes from Mice Deficient in the MSH2 Mismatch Repair Protein

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12 December 2020

DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells

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12 December 2020

Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications

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12 December 2020

Molecular Biology of Aging

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12 December 2020

Bias in somatic hypermutation of human VH genes.

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12 December 2020

Mismatch Repair Deficiency Interferes with the Accumulation of Mutations in Chronically Stimulated B Cells and Not with the Hypermutation Process

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12 December 2020

Structural repertoire of the human VH segments

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12 December 2020

Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus

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12 December 2020

Autoantibodies encoded by the most Jh-proximal human immunoglobulin heavy chain variable region gene

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12 December 2020

PMS2-deficiency diminishes hypermutation of a lambda1 transgene in young but not older mice

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12 December 2020

Transcriptional and posttranscriptional control of immunoglobulin mRNA production during B lymphocyte development

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12 December 2020

Codon bias targets mutation.

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12 December 2020

An anti-lipid A antibody obtained from the human fetal repertoire is encoded by VH6-V lambda 1 genes

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12 December 2020

poliota, a remarkably error-prone human DNA polymerase

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12 December 2020

On the origin of multiple mutations in human cancers

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12 December 2020

Quality control by DNA repair

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12 December 2020

Mismatch Repair Deficiency in Phenotypically Normal Human Cells

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12 December 2020

Somatic Hypermutation Introduces Insertions and Deletions into Immunoglobulin V Genes

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12 December 2020

Ig VH hypermutation is absent in the germinal centers of aged mice

1 reference

12 December 2020

Mammalian DNA mismatch repair

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12 December 2020

The contribution of somatic hypermutation to the diversity of serum immunoglobulin: dramatic increase with age

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12 December 2020

Hot Spot Focusing of Somatic Hypermutation in MSH2-Deficient Mice Suggests Two Stages of Mutational Targeting

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12 December 2020

Immunoglobulin VH gene expression in human aging

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12 December 2020

Low fidelity DNA synthesis by human DNA polymerase-eta

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12 December 2020

Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

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12 December 2020

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12 December 2020

Mismatch repair co-opted by hypermutation.

1 reference

12 December 2020

Human immunoglobulin (Ig)M IgD peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells

1 reference

12 December 2020

The effect of donor age on the processing of UV-damaged DNA by cultured human cells: reduced DNA repair capacity and increased DNA mutability

1 reference

12 December 2020

Immunoglobulin Heavy Chain Junctional Diversity in Young and Aged Humans

1 reference

12 December 2020

Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

1 reference

12 December 2020

Spontaneous length variation in microsatellite DNA from human T-cell clones.

1 reference

12 December 2020

Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice

1 reference

12 December 2020

Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

1 reference

12 December 2020

Expressed human immunoglobulin kappa genes and their hypermutation

1 reference

12 December 2020

Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

1 reference

12 December 2020

Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes

1 reference

12 December 2020

Mitochondrial DNA repair pathways

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12 December 2020

B cells are generated throughout life in humans

1 reference

12 December 2020

Molecular characterization of human antibodies to bacterial antigens: utilization of the less frequently expressed VH2 and VH6 heavy chain variable region gene families

1 reference

12 December 2020

The smaller human VH gene families display remarkably little polymorphism

1 reference

12 December 2020

Hypermutation, diversity and dissemination of human intestinal lamina propria plasma cells

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12 December 2020

DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

1 reference

12 December 2020

Clusters of point mutations are found exclusively around rearranged antibody variable genes

1 reference

12 December 2020

Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.

1 reference

12 December 2020

1 reference

12 December 2020

Evidence for a large compartment of IgM-expressing memory B cells in humans.

1 reference

12 December 2020

A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro

1 reference

12 December 2020

Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes

1 reference

12 December 2020

Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individuals

1 reference

12 December 2020

1 reference

12 December 2020

Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

1 reference

12 December 2020

Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development.

1 reference

12 December 2020

Predicting regional mutability in antibody V genes based solely on di- and trinucleotide sequence composition

1 reference

12 December 2020

Human IgM IgD B cells, the major B cell subset in the peripheral blood, express V kappa genes with no or little somatic mutation throughout life

1 reference

12 December 2020