Inactivation of Thrombin by Antithrombin Is Accompanied by Inactivation of Regulatory Exosite I (Q73555526)

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4 November 2019

title

Inactivation of thrombin by antithrombin is accompanied by inactivation of regulatory exosite I (English)

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4 November 2019

Inactivation of Thrombin by Antithrombin Is Accompanied by Inactivation of Regulatory Exosite I (English)

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https://api.crossref.org/works/10.1074/JBC.272.32.19837

9 November 2024

author name string

P. E. Bock

1

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9 November 2024

S. T. Olson

2

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9 November 2024

I. Björk

3

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9 November 2024

language of work or name

English

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publication date

1 August 1997

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4 November 2019

8 August 1997

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9242645

full work available at URL

9 November 2024

http://www.jbc.org/content/272/32/19837.full.pdf

file format

Portable Document Format

online access status

open access

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https://api.elsevier.com/content/article/PII:S0021925818388574?httpAccept=text/xml

9 November 2024

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https://api.elsevier.com/content/article/PII:S0021925818388574?httpAccept=text/plain

9 November 2024

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https://syndication.highwire.org/content/doi/10.1074/jbc.272.32.19837

9 November 2024

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Journal of Biological Chemistry

9 November 2024

published in

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4 November 2019

volume

272

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4 November 2019

issue

32

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4 November 2019

page(s)

19837-19845

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A player of many parts: the spotlight falls on thrombin's structure.

4 November 2019

cites work

1 reference

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The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

21 January 2018

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Refined structure of the hirudin-thrombin complex

21 January 2018

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Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms

21 January 2018

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Involvement of thrombin anion-binding exosites 1 and 2 in the activation of factor V and factor VIII

21 January 2018

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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

21 January 2018

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Characterization of the kinetic pathway for fibrin promotion of alpha-thrombin-catalyzed activation of plasma factor XIII

21 January 2018

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Equilibrium binding of thrombin to recombinant human thrombomodulin: effect of hirudin, fibrinogen, factor Va, and peptide analogues.

21 January 2018

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Enzymatic properties of proteolytic derivatives of human alpha-thrombin

21 January 2018

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Fibrin monomer protects thrombin from inactivation by heparin-antithrombin III: implications for heparin efficacy.

21 January 2018

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Different glycoforms of human thrombomodulin. Their glycosaminoglycan-dependent modulatory effects on thrombin inactivation by heparin cofactor II and antithrombin III

21 January 2018

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Effect of thrombomodulin on the kinetics of the interaction of thrombin with substrates and inhibitors

21 January 2018

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Structural basis for serpin inhibitor activity

21 January 2018

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Thioester peptide chloromethyl ketones: reagents for active site-selective labeling of serine proteinases with spectroscopic probes

21 January 2018

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Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin.

21 January 2018

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Reaction of thrombins with human antithrombin III. I. Enzyme activity losses unrelated to the inhibitory reaction and their prevention

21 January 2018

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Quantitative evaluation of solution equilibrium binding interactions by affinity partitioning: application to specific and nonspecific protein-heparin interactions.

21 January 2018

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Papain labelled with fluorescent thiol-specific reagents as a probe for characterization of interactions between cysteine proteinases and their protein inhibitors by competitive titrations

21 January 2018

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Partial purification by guanosine-5'-diphosphate--agarose affinity chromatography of the 32,000 molecular weight polypeptide from mitochondria of brown adipose tissue

21 January 2018

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Mobile reactive centre of serpins and the control of thrombosis

21 January 2018

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Synthesis of pppGpN typs dinucleotide derivatives: the 5′ end sequence of some RNAs

21 January 2018

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The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions

21 January 2018

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Role of the catalytic serine in the interactions of serine proteinases with protein inhibitors of the serpin family. Contribution of a covalent interaction to the binding energy of serpin-proteinase complexes.

21 January 2018

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The production of an inactive form of antithrombin through limited proteolysis by thrombin

21 January 2018

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Role of the P2 residue in determining the specificity of serpins

21 January 2018

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Major proteinase movement upon stable serpin-proteinase complex formation

21 January 2018

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Isolation of human erythrocyte membranes and their outer surface proteins by covalent fractionation on solid support

21 January 2018

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Formation and stability of the complex formed between human antithrombin-III and thrombin

21 January 2018

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Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin

21 January 2018

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21 January 2018

31

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Release of a Two-Chain Form of Antithrombin from the Antithrombin-Thrombin Complex

9 November 2024

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Biological implications of a 3 A structure of dimeric antithrombin

9 November 2024

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Routes of Thrombin Action in the Production of Proteolytically Modified, Secondary Forms of Antithrombin-Thrombin Complex

9 November 2024

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9 November 2024

Identifiers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9242645 AND SRC:MED&resulttype=core&format=json

4 November 2019

1 reference