Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects (Q73538051)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10712917 AND SRC:MED&resulttype=core&format=json

4 November 2019

title

Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10712917 AND SRC:MED&resulttype=core&format=json

4 November 2019

author name string

G C Prendergast

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10712917 AND SRC:MED&resulttype=core&format=json

4 November 2019

publication date

1 April 2000

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Current Opinion in Cell Biology

4 November 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10712917 AND SRC:MED&resulttype=core&format=json

4 November 2019

volume

12

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4 November 2019

issue

2

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4 November 2019

page(s)

166-173

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Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

4 November 2019

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Protein prenylation: molecular mechanisms and functional consequences

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Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

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Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

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Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

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A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

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Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

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Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

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Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells

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Non-Ras targets of farnesyltransferase inhibitors: focus on Rho.

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Metabolic turnover of human c-rasH p21 protein of EJ bladder carcinoma and its normal cellular and viral homologs

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Gene trapping identifies inhibitors of oncogenic transformation. The tissue inhibitor of metalloproteinases-3 (TIMP3) and collagen type I alpha2 (COL1A2) are epidermal growth factor-regulated growth repressors

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7 January 2021

Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity

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Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

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Effects of the farnesyltransferase inhibitor UCF-1C/manumycin on growth and p21-ras post-translational processing in NIH3T3 cells

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

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7 January 2021

Intracellular localization of the P21rho proteins

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Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB

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PRK1 is targeted to endosomes by the small GTPase, RhoB

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Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB

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Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.

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Rho GTPases are over-expressed in human tumors.

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7 January 2021

An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

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7 January 2021

Orthotopic models are necessary to predict therapy of transplantable tumors in mice

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7 January 2021

A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors

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7 January 2021

Effect of farnesyltransferase overexpression on cell growth and transformation

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7 January 2021

Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway

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Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones

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7 January 2021

rhoB Encoding a UV-inducible Ras-related Small GTP-binding Protein Is Regulated by GTPases of the Rho Family and Independent of JNK, ERK, and p38 MAP Kinase

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Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10712917 AND SRC:MED&resulttype=core&format=json

4 November 2019

1 reference