MeIQx-DNA adduct formation in rodent and human tissues at low doses (Q73457812)

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4 November 2019

title

MeIQx-DNA adduct formation in rodent and human tissues at low doses (English)

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4 November 2019

author name string

K W Turteltaub

1

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4 November 2019

R J Mauthe

2

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4 November 2019

K H Dingley

3

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4 November 2019

J S Vogel

4

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4 November 2019

C E Frantz

5

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4 November 2019

R C Garner

6

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4 November 2019

N Shen

7

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4 November 2019

language of work or name

English

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publication date

1 May 1997

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4 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9202761 AND SRC:MED&resulttype=core&format=json

4 November 2019

volume

376

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4 November 2019

issue

1-2

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4 November 2019

page(s)

243-252

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Enzymatic phase II activation of the N-hydroxylamines of IQ, MeIQx and PhIP by various organs of monkeys and rats.

4 November 2019

cites work

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Estimation of exposure of man to substances reacting covalently with macromolecules

7 January 2021

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Dose-response studies of MeIQx in rat liver and liver DNA at low doses.

7 January 2021

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Application of biomarkers to risk assessment

7 January 2021

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Heterocyclic amines formed by cooking food: comparison of bioassay results with other chemicals in the Carcinogenic Potency Database

7 January 2021

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Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases.

7 January 2021

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Formation and removal of DNA adducts in the liver of rats chronically fed the food-borne carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

7 January 2021

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Expression of monomorphic and polymorphic N-acetyltransferases in human colon

7 January 2021

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Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

7 January 2021

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Dose-response study of MeIQx carcinogenicity in F344 male rats.

7 January 2021

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Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research

7 January 2021

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In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis

7 January 2021

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N-and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells

7 January 2021

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Expression of exposure in negative carcinogenicity studies: dose/body weight, dose/body surface area, or plasma concentrations?

7 January 2021

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Identification of N2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethyl-imidazo[4,5- f]quinoxaline 3',5'-diphosphate, a major DNA adduct, detected by nuclease P1 modification of the 32P-postlabeling method, in the liver of rats fed MeIQx

7 January 2021

1 reference

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Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) from cooked foods

7 January 2021

1 reference

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DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models: implications for DNA adduct-based human cancer risk assessment.

7 January 2021

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Disposition and metabolism of the food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in rats

7 January 2021

1 reference

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32P-postlabeling analysis of IQ, MeIQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MeIQx- and PhIP-treated monkeys.

7 January 2021

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Risk of death from cancer and ischaemic heart disease in meat and non-meat eaters

7 January 2021

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Presence of N2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues.

7 January 2021

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Major routes of metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in the rat

7 January 2021

1 reference

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Characterization of DNA adducts formed in vitro by reaction of N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline at the C-8 and N2 atoms of guanine.

7 January 2021

1 reference

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Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA

7 January 2021

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Role of metabolism on the DNA binding of MeIQx in mice and bacteria

7 January 2021

1 reference

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DNA adducts formed by 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rat liver: dose-response on chronic administration.

7 January 2021

1 reference

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10.1016/S0027-5107(97)00049-3

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9202761 AND SRC:MED&resulttype=core&format=json

4 November 2019

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