Dissociation of the recombination control and the sequence-specific transactivation function of P53 (Q73088400)

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1 November 2019

title

Dissociation of the recombination control and the sequence-specific transactivation function of P53 (English)

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1 November 2019

author name string

C Dudenhöffer

1

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1 November 2019

M Kurth

2

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1 November 2019

F Janus

3

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1 November 2019

W Deppert

4

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1 November 2019

L Wiesmüller

5

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1 November 2019

language of work or name

English

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publication date

1 October 1999

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1 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10523858 AND SRC:MED&resulttype=core&format=json

1 November 2019

volume

18

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1 November 2019

issue

42

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1 November 2019

page(s)

5773-5784

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p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

1 November 2019

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Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.

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A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein

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Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways

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The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity

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Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein

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The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis

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Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination

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WAF1, a potential mediator of p53 tumor suppression

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Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

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Specific p53-DNA complexes contain an mdm2-related protein

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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14-3-3sigma is a p53-regulated inhibitor of G2/M progression

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p53 mutations in human cancers

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Regulation of the specific DNA binding function of p53

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Oligomerization is not essential for growth suppression by p53 in p53-deficient osteosarcoma Saos-2 cells

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Cell-cycle control and its watchman.

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Different regulation of the p53 core domain activities 3'-to-5' exonuclease and sequence-specific DNA binding

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Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

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Oncogenic forms of p53 inhibit p53-regulated gene expression

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DNA-conformation is an important determinant of sequence-specific DNA binding by tumor suppressor p53

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p53 Is Phosphorylated by CDK7-Cyclin H in a p36MAT1-Dependent Manner

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Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells

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7 January 2021

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

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7 January 2021

Human p53 binds Holliday junctions strongly and facilitates their cleavage

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7 January 2021

A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

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7 January 2021

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

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7 January 2021

The CDK7-cycH-p36 Complex of Transcription Factor IIH Phosphorylates p53, Enhancing Its Sequence-Specific DNA Binding Activity In Vitro

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Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

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7 January 2021

A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation

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7 January 2021

Inactivation of p53 results in high rates of homologous recombination

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7 January 2021

p53 Protein exhibits 3'-to-5' exonuclease activity

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7 January 2021

DNA bending is essential for the site-specific recognition of DNA response elements by the DNA binding domain of the tumor suppressor protein p53.

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7 January 2021

p53-catalyzed annealing of complementary single-stranded nucleic acids

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7 January 2021

Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53

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7 January 2021

BRCA1 regulates p53-dependent gene expression

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Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

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7 January 2021

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation

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Signaling to p53: breaking the MDM2-p53 circuit

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Association of BRCA1 with Rad51 in mitotic and meiotic cells

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Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation.

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7 January 2021

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

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7 January 2021

p53 oligomerization and DNA looping are linked with transcriptional activation

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7 January 2021

Formation of stable p53 homotetramers and multiples of tetramers

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7 January 2021

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction

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7 January 2021

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice

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7 January 2021

p53 function and dysfunction

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7 January 2021

An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53

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7 January 2021

Wild-type p53 is not a negative regulator of simian virus 40 DNA replication in infected monkey cells.

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7 January 2021

p53 domains: structure, oligomerization, and transformation

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7 January 2021

p53 modulation of TFIIH–associated nucleotide excision repair activity

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7 January 2021

The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding

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7 January 2021

In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes

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7 January 2021

Specific interaction of mutant p53 with regions of matrix attachment region DNA elements (MARs) with a high potential for base-unpairing

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7 January 2021

REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism

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7 January 2021

Isolation of a full-length mouse cDNA clone coding for an immunologically distinct p53 molecule

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7 January 2021

Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids

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7 January 2021

Activities and response to DNA damage of latent and active sequence-specific DNA binding forms of mouse p53

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7 January 2021

p21 is a universal inhibitor of cyclin kinases

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7 January 2021

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

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7 January 2021

BRCA1 physically associates with p53 and stimulates its transcriptional activity.

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7 January 2021