RAR related orphan receptor A (Q7275807)

Zinc finger, NHR/GATA-type

1 reference

nuclear receptor ROR

1 reference

Nuclear hormone receptor, ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, nuclear hormone receptor-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

sequence-specific DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

beta-catenin binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

8 April 2019

The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

ligand-activated transcription factor activity

1 reference

8 April 2019

Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

DNA-binding transcription factor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

7 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

zinc ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

1 reference

8 April 2019

transcription factor binding

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

1 reference

8 April 2019

steroid hormone receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

1 reference

8 April 2019

nuclear receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

1 reference

8 April 2019

core promoter sequence-specific DNA binding

1 reference

24 April 2018

Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35398&geneProductId=UniProtKB:P35398

protein binding

4 references

8 April 2019

Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

transcription coactivator binding

Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD

3 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35398&geneProductId=UniProtKB:P35398

5 June 2018

Coactivators for the orphan nuclear receptor RORalpha

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35398&geneProductId=UniProtKB:P35398

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35398&geneProductId=UniProtKB:P35398

transcription corepressor binding

1 reference

8 April 2019

Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

oxysterol binding

1 reference

5 June 2018

Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35398&geneProductId=UniProtKB:P35398

DNA-binding transcription activator activity, RNA polymerase II-specific

Norwegian University of Science and Technology, Systems Biology team

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

DNA-binding transcription factor activity, RNA polymerase II-specific

IC

A census of human transcription factors: function, expression and evolution

3 references

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

NAS

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

Norwegian University of Science and Technology, Systems Biology team

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

RNA polymerase II cis-regulatory region sequence-specific DNA binding

ISA

1 reference

8 April 2019

Modulation of clock gene expression by the transcriptional coregulator receptor interacting protein 140 (RIP140)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

transcription coactivator binding

Coactivators for the orphan nuclear receptor RORalpha

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

IBA

oxysterol binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

1 reference

8 April 2019

TAS

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

nitric oxide biosynthetic process

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

cGMP metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

rhythmic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

1 reference

8 April 2019

cellular response to sterol

cellular response to tumor necrosis factor

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

cerebellar Purkinje cell differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

negative regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

8 April 2019

The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35398&geneProductId=UniProtKB:P35398

1 reference

5 June 2018

muscle cell differentiation

1 reference

8 April 2019

Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

intracellular receptor signaling pathway

1 reference

8 April 2019

Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

regulation of circadian rhythm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

angiogenesis

1 reference

8 April 2019

Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

cellular response to interleukin-1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

positive regulation of vascular endothelial growth factor production

1 reference

8 April 2019

Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

transcription initiation from RNA polymerase II promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

1 reference

8 April 2019

negative regulation of inflammatory response

TAS

1 reference

5 June 2018

The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35398&geneProductId=UniProtKB:P35398

cellular response to hypoxia

1 reference

8 April 2019

Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

regulation of macrophage activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

positive regulation of transcription by RNA polymerase II

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

8 April 2019

Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

steroid hormone mediated signaling pathway

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

circadian rhythm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

cytokine-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

1 reference

8 April 2019

negative regulation of inflammatory response

TAS

IBA

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35398

1 reference

8 April 2019

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

2718

English

nuclear hormone receptor-type zinc finger

17 August 2016

Gene Atlas image

PBB GE RORA 210479 s at fs.png
732 × 530; 10 KB

0 references

has part(s)

1 reference

Nuclear hormone receptor, ligand-binding domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016