Protein tyrosine phosphatase non-receptor type 11 (Q7120997)

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mammalian protein found in Homo sapiens
  • protein-tyrosine phosphatase 1D
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11
  • Shp2
  • protein-tyrosine phosphatase 2C
  • tyrosine-protein phosphatase non-receptor type 11
  • PTP-1D
  • SH-PTP3
  • PTPN11
  • PTP-2C
  • SHP-2
  • SH-PTP2
edit
Language Label Description Also known as
English
Protein tyrosine phosphatase non-receptor type 11
mammalian protein found in Homo sapiens
  • protein-tyrosine phosphatase 1D
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11
  • Shp2
  • protein-tyrosine phosphatase 2C
  • tyrosine-protein phosphatase non-receptor type 11
  • PTP-1D
  • SH-PTP3
  • PTPN11
  • PTP-2C
  • SHP-2
  • SH-PTP2

Statements

molecular function
protein binding
determination method or standard
IPI
66 references
retrieved
8 April 2019
stated in
FCRL6 receptor: expression and associated proteins.
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of CD112R as a novel checkpoint for human T cells
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of CLEC12B, an inhibitory receptor on myeloid cells.
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of protein tyrosine phosphatases associating with the PDGF receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Localization of the Insulin-like Growth Factor I Receptor Binding Sites for the SH2 Domain Proteins p85, Syp, and GTPase Activating Protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
A2 isoform of mammalian translation factor eEF1A displays increased tyrosine phosphorylation and ability to interact with different signalling molecules
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Distinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of natural ligands for SH2 domains from a phage display cDNA library
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Fine specificity and molecular competition in SLAM family receptor signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
An ITIM-like motif within the CCK2 receptor sequence required for interaction with SHP-2 and the activation of the AKT pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Association of protein tyrosine phosphatases (PTPs)-1B with c-Met receptor and modulation of corneal epithelial wound healing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction of SH2-containing protein tyrosine phosphatase 2 with the insulin receptor and the insulin-like growth factor-I receptor: studies of the domains involved using the yeast two-hybrid system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Activation of gp130 transduces hypertrophic signal through interaction of scaffolding/docking protein Gab1 with tyrosine phosphatase SHP2 in cardiomyocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct determination of the sequence recognition requirements of the SH2 domains of SH-PTP2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Adapter function of protein-tyrosine phosphatase 1D in insulin receptor/insulin receptor substrate-1 interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Charting the molecular network of the drug target Bcr-Abl
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
ITIM-dependent endocytosis of CD33-related Siglecs: role of intracellular domain, tyrosine phosphorylation, and the tyrosine phosphatases, Shp1 and Shp2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of platelet/endothelial cell adhesion molecule-1 (PECAM-1) that are required for the cellular association and activation of the protein-tyrosine phosphatase, SHP-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Co-clustering of Fcgamma and B cell receptors induces dephosphorylation of the Grb2-associated binder 1 docking protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterization of protein tyrosine phosphatase SH-PTP2. Study of phosphopeptide substrates and possible regulatory role of SH2 domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
retrieved
8 April 2019
stated in
Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IPI
protein tyrosine phosphatase activity
determination method or standard
EXP
IDA
IEA
IMP
TAS
11 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
TAS
retrieved
8 April 2019
stated in
Identification of CLEC12B, an inhibitory receptor on myeloid cells.
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IMP
retrieved
8 April 2019
stated in
The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IEA
retrieved
8 April 2019
stated in
Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IDA
retrieved
8 April 2019
stated in
Structural, Functional, and Clinical Characterization of a Novel PTPN11 Mutation Cluster Underlying Noonan Syndrome
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IDA
retrieved
8 April 2019
stated in
The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling
GOA
curator
UniProt
UniProt protein ID
Q06124
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IDA
retrieved
8 April 2019
stated in
Src homology-2 domain-containing protein tyrosine phosphatase (SHP) 2 and p38 regulate the expression of chemokine CXCL8 in human astrocytes
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
IDA
retrieved
8 April 2019
stated in
A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06124
determination method or standard
EXP
cell component
biological process
Gene Atlas image
PBB GE PTPN11 gnf1h09380 s at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D054592
subject named as
Protein Tyrosine Phosphatase, Non-Receptor Type 11
1 reference
reference URL
https://meshb.nlm.nih.gov/#/record/ui?ui=D054592
PDB structure ID
 
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