The enantiomers of the valproic acid analogue 2-n-propyl-4-pentynoic acid (4-yn-VPA): asymmetric synthesis and highly stereoselective teratogenicity in mice (Q67583915)

From Wikidata

Jump to navigation Jump to search

scientific article published on 01 July 1992

Language	Label	Description	Also known as
English	The enantiomers of the valproic acid analogue 2-n-propyl-4-pentynoic acid (4-yn-VPA): asymmetric synthesis and highly stereoselective teratogenicity in mice	scientific article published on 01 July 1992

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995 AND SRC:MED&resulttype=core&format=json

15 September 2019

The enantiomers of the valproic acid analogue 2-n-propyl-4-pentynoic acid (4-yn-VPA): asymmetric synthesis and highly stereoselective teratogenicity in mice (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995 AND SRC:MED&resulttype=core&format=json

15 September 2019

stereoselectivity

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

R. S. Hauck

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:1437995

26 September 2022

H. Nau

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:1437995

26 September 2022

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1437995

26 September 2022

publication date

1 July 1992

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995 AND SRC:MED&resulttype=core&format=json

15 September 2019

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995 AND SRC:MED&resulttype=core&format=json

15 September 2019

9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995 AND SRC:MED&resulttype=core&format=json

15 September 2019

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995 AND SRC:MED&resulttype=core&format=json

15 September 2019

850-855

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995 AND SRC:MED&resulttype=core&format=json

15 September 2019

Transfer of valproic acid and its main active unsaturated metabolite to the gestational tissue: correlation with neural tube defect formation in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid and spina bifida

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid teratogenicity in mice after various administration and phenobarbital-pretreatment regimens: the parent drug and not one of the metabolites assayed is implicated as teratogen

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymmetric synthesis and teratogenic activity of (R)- and (S)-2-ethylhexanoic acid, a metabolite of the plasticizer di-(2-ethylhexyl)phthalate

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the development of alternative antiepileptic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid-induced neural tube defects: reduction by folinic acid in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymmetric synthesis and enantioselective teratogenicity of 2-n-propyl-4-pentenoic acid (4-en-VPA), an active metabolite of the anticonvulsant drug, valproic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Structural bases of the teratogenic effects of the antiepileptic valproic acid. 2-n-propyl-4-pentenic acid, the first structural analogue with significantly higher teratogenic action than VPA].

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Teratogenic valproic acid concentrations: infusion by implanted minipumps vs conventional injection regimen in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible teratogenic effect of valproate during pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacologic evaluation of various metabolites and analogs of valproic acid: teratogenic potencies in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic Acid-Induced Neural Tube Defects in Mouse and Human: Aspects of Chirality, Alternative Drug Development, Pharmacokinetics and Possible Mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The enantioselective teratogenicity of 2-n-propyl-4-pentynoic acid (4-yn-VPA) is due to stereoselective intrinsic activity and not differences in pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enantioselective synthesis and preliminary metabolic studies of the optical isomers of 2-n-propyl-4-pentenoic acid, a hepatotoxic metabolite of valproic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproate and birth defects

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new model for embryotoxicity testing: teratogenicity and pharmacokinetics of valproic acid following constant-rate administration in the mouse using human therapeutic drug and metabolite concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optical isomerism and pharmacological action, a generalization

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spina bifida and in-utero exposure to valproate

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maternal valproic acid and congenital neural tube defects

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In-utero exposure to valproate and neural tube defects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simplified method of evaluating dose-effect experiments

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A note on a simple apparatus for detecting neurological deficit in rats and mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/1437995

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1015832411981

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995 AND SRC:MED&resulttype=core&format=json

15 September 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1437995 AND SRC:MED&resulttype=core&format=json

15 September 2019

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q67583915&oldid=1891383957"