Lymphoid enhancer binding factor 1 (Q6708270)

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mammalian protein found in Homo sapiens
  • T cell-specific transcription factor 1-alpha
  • LEF1
  • lymphoid enhancer-binding factor 1
  • TCF1-alpha
edit
Language Label Description Also known as
English
Lymphoid enhancer binding factor 1
mammalian protein found in Homo sapiens
  • T cell-specific transcription factor 1-alpha
  • LEF1
  • lymphoid enhancer-binding factor 1
  • TCF1-alpha

Statements

molecular function
protein binding
determination method or standard
IPI
11 references
retrieved
8 April 2019
stated in
I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
8 April 2019
stated in
Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nuclear IGF1R is a transcriptional co-activator of LEF1/TCF
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
8 April 2019
stated in
Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
8 April 2019
stated in
Vitamin D receptor is essential for normal keratinocyte stem cell function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
8 April 2019
stated in
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
8 April 2019
stated in
The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
8 April 2019
stated in
Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
beta-catenin binding
determination method or standard
IDA
IEA
IPI
TAS
8 references
retrieved
16 July 2018
stated in
Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
TAS
retrieved
16 July 2018
stated in
Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
16 July 2018
stated in
Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
16 July 2018
stated in
ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
16 July 2018
stated in
Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
16 July 2018
stated in
Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IEA
retrieved
16 July 2018
stated in
Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
beta-catenin binding
determination method or standard
IBA
IDA
IEA
IPI
TAS
9 references
retrieved
8 April 2019
stated in
Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
TAS
retrieved
8 April 2019
stated in
Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
8 April 2019
stated in
Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
8 April 2019
stated in
Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
8 April 2019
stated in
ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IPI
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IEA
retrieved
8 April 2019
stated in
Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IBA
DNA-binding transcription factor activity, RNA polymerase II-specific
determination method or standard
IBA
IEA
ISA
ISM
NAS
5 references
retrieved
1 January 2018
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
NAS
retrieved
1 January 2018
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
ISM
retrieved
1 January 2018
stated in
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
ISA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IEA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IBA
cell component
nucleus
determination method or standard
IC
IDA
IEA
7 references
retrieved
10 September 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IEA
retrieved
10 September 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IEA
retrieved
10 September 2018
stated in
LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
10 September 2018
stated in
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
10 September 2018
stated in
Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
10 September 2018
stated in
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
10 September 2018
stated in
A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IC
nucleus
determination method or standard
IBA
IC
IDA
IEA
8 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IEA
retrieved
8 April 2019
stated in
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
8 April 2019
stated in
LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
8 April 2019
stated in
Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
8 April 2019
stated in
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
8 April 2019
stated in
A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IC
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IBA
biological process
positive regulation of transcription, DNA-templated
determination method or standard
IDA
IEA
IMP
7 references
retrieved
10 September 2018
stated in
LEF1 in androgen-independent prostate cancer: regulation of androgen receptor expression, prostate cancer growth, and invasion
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IMP
retrieved
10 September 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IEA
retrieved
10 September 2018
stated in
SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
10 September 2018
stated in
Activation of the HIV-1 enhancer by the LEF-1 HMG protein on nucleosome-assembled DNA in vitro
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
10 September 2018
stated in
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
10 September 2018
stated in
Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
10 September 2018
stated in
Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UJU2&geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
positive regulation of transcription, DNA-templated
determination method or standard
IBA
IDA
IEA
IMP
8 references
retrieved
8 April 2019
stated in
LEF1 in androgen-independent prostate cancer: regulation of androgen receptor expression, prostate cancer growth, and invasion
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IEA
retrieved
8 April 2019
stated in
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
8 April 2019
stated in
Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
8 April 2019
stated in
SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
8 April 2019
stated in
Activation of the HIV-1 enhancer by the LEF-1 HMG protein on nucleosome-assembled DNA in vitro
GOA
curator
UniProt
UniProt protein ID
Q9UJU2
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
8 April 2019
stated in
Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UJU2
determination method or standard
IBA
Gene Atlas image
PBB GE LEF1 221558 s at fs.png
732 × 530; 10 KB
0 references

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q6708270&oldid=2022908960"