Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos. (Q65002198)

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2 May 2020

review article

3 references

3 October 2022

28 October 2022

Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos (English)

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2 May 2020

main subject

necroptosis

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macrophage

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parthanatos

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pyroptosis

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1

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2 May 2020

6

László Virág

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2 May 2020

3

Csaba Hegedűs

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2 May 2020

author name string

Raja Ganesan

series ordinal

2

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2 May 2020

Katalin Kovács

series ordinal

4

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2 May 2020

Thomas A Kufer

series ordinal

5

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2 May 2020

publication date

9 June 2019

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2 May 2020

1 September 2019

2 references

3 October 2022

28 October 2022

3 references

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2 May 2020

3 October 2022

28 October 2022

26

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2 May 2020

page(s)

101239

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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

2 May 2020

copyright license

2 references

3 October 2022

Tumor necrosis factor-mediated cytotoxicity involves ADP-ribosylation

28 October 2022

cites work

1 reference

12 December 2020

Poly(ADP-ribose) polymerase mediates the suicide response to massive DNA damage: studies in normal and DNA-repair defective cells

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12 December 2020

Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide.

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12 December 2020

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

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12 December 2020

Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death

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12 December 2020

Peroxynitrite-induced thymocyte apoptosis: the role of caspases and poly (ADP-ribose) synthetase (PARS) activation

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12 December 2020

Shigella-induced apoptosis is dependent on caspase-1 which binds to IpaB

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12 December 2020

The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1

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12 December 2020

Requirement of intracellular calcium mobilization for peroxynitrite-induced poly(ADP-ribose) synthetase activation and cytotoxicity

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12 December 2020

BCL-2 protects peroxynitrite-treated thymocytes from poly(ADP-ribose) synthase (PARS)-independent apoptotic but not from PARS-mediated necrotic cell death

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12 December 2020

Pro-inflammatory programmed cell death

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12 December 2020

Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation.

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12 December 2020

Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

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12 December 2020

The therapeutic potential of poly(ADP-ribose) polymerase inhibitors

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12 December 2020

Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention

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12 December 2020

Necrotic death of Rhodococcus equi-infected macrophages is regulated by virulence-associated plasmids.

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12 December 2020

Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: focus on cell death and transcriptional regulation

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12 December 2020

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

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12 December 2020

Sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent macrophages

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12 December 2020

Activation of poly(ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus

1 reference

12 December 2020

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

1 reference

12 December 2020

Mitochondrial and nuclear cross talk in cell death: parthanatos

1 reference

12 December 2020

Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells

1 reference

12 December 2020

Nlrp3: an immune sensor of cellular stress and infection

1 reference

12 December 2020

Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease

1 reference

12 December 2020

Signaling by ROS drives inflammasome activation

1 reference

12 December 2020

1 reference

12 December 2020

Human NLRP3 inflammasome activation is Nox1-4 independent

1 reference

12 December 2020

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

1 reference

12 December 2020

Molecular mechanisms of necroptosis: an ordered cellular explosion

1 reference

12 December 2020

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

1 reference

12 December 2020

Tumor necrosis factor-α signaling in macrophages.

1 reference

12 December 2020

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.

1 reference

12 December 2020

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

1 reference

12 December 2020

Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.

1 reference

12 December 2020

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

1 reference

12 December 2020

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways

1 reference

12 December 2020

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

1 reference

12 December 2020

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

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12 December 2020

cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation.

1 reference

12 December 2020

p53 opens the mitochondrial permeability transition pore to trigger necrosis

1 reference

12 December 2020

Redox control of NLRP3 inflammasome activation in health and disease

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12 December 2020

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

1 reference

12 December 2020

TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species

1 reference

12 December 2020

Origin and differentiation of microglia

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12 December 2020

Noncanonical inflammasome activation by intracellular LPS independent of TLR4.

1 reference

12 December 2020

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

1 reference

12 December 2020

Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock

1 reference

12 December 2020

Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation

1 reference

12 December 2020

Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

1 reference

12 December 2020

Ars Moriendi; the art of dying well - new insights into the molecular pathways of necroptotic cell death

1 reference

12 December 2020

PARP-1 hyperactivation and reciprocal elevations in intracellular Ca2 during ROS-induced nonapoptotic cell death

1 reference

12 December 2020

Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation

1 reference

12 December 2020

XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation

1 reference

12 December 2020

PARP1-mediated necrosis is dependent on parallel JNK and Ca²⁺/calpain pathways

1 reference

12 December 2020

Monosodium urate crystals trigger Nrf2- and heme oxygenase-1-dependent inflammation in THP-1 cells

1 reference

12 December 2020

Inflammatory caspases are innate immune receptors for intracellular LPS.

1 reference

12 December 2020

Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection

1 reference

12 December 2020

PARP-1 mediates LPS-induced HMGB1 release by macrophages through regulation of HMGB1 acetylation

1 reference

12 December 2020

RIP3 induces apoptosis independent of pronecrotic kinase activity

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12 December 2020

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

1 reference

12 December 2020

The NAIP/NLRC4 inflammasomes

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12 December 2020

RIPK1 and RIPK3: critical regulators of inflammation and cell death

1 reference

12 December 2020

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

1 reference

12 December 2020

The NLRP1 inflammasomes

1 reference

12 December 2020

Toxin-induced necroptosis is a major mechanism of Staphylococcus aureus lung damage.

1 reference

12 December 2020

Activation of the Nrf2-regulated antioxidant cell response inhibits HEMA-induced oxidative stress and supports cell viability.

1 reference

12 December 2020

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

1 reference

12 December 2020

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.

1 reference

12 December 2020

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

1 reference

12 December 2020

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

1 reference

12 December 2020

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

1 reference

12 December 2020

Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia

1 reference

12 December 2020

Infiltrated Macrophages Die of Pneumolysin-Mediated Necroptosis following Pneumococcal Myocardial Invasion

1 reference

12 December 2020

Exogenous NAD( ) decreases oxidative stress and protects H2O2-treated RPE cells against necrotic death through the up-regulation of autophagy

1 reference

12 December 2020

Proteasome inhibitor PS-341 limits macrophage necroptosis by promoting cIAPs-mediated inhibition of RIP1 and RIP3 activation

1 reference

12 December 2020

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

1 reference

12 December 2020

Microglial activation induced by the alarmin S100B is regulated by poly(ADP-ribose) polymerase-1.

1 reference

12 December 2020

Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis

1 reference

12 December 2020

Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis

1 reference

12 December 2020

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

1 reference

12 December 2020

AIF-independent parthanatos in the pathogenesis of dry age-related macular degeneration

1 reference

12 December 2020

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

1 reference

12 December 2020

Programmed cell death as a defence against infection

1 reference

12 December 2020

Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy

1 reference

12 December 2020

PARP inhibition protects mitochondria and reduces ROS production via PARP-1-ATF4-MKP-1-MAPK retrograde pathway

1 reference

12 December 2020

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.

1 reference

12 December 2020

Cell Death Mechanisms of Neurodegeneration

1 reference

12 December 2020

XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.

1 reference

12 December 2020

Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses

1 reference

12 December 2020

Specificity of reversible ADP-ribosylation and regulation of cellular processes.

1 reference

12 December 2020

Function and mechanism of the pyrin inflammasome

1 reference

12 December 2020

The AIM2 inflammasome: Sensor of pathogens and cellular perturbations

1 reference

12 December 2020

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

1 reference

12 December 2020

Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis.

1 reference

12 December 2020

Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1

1 reference

12 December 2020

NAD Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis

1 reference

12 December 2020

Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis

1 reference

12 December 2020

Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes

1 reference

12 December 2020

GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity

1 reference

12 December 2020

Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death

1 reference

12 December 2020

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during infection

1 reference

12 December 2020

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease

1 reference

12 December 2020

Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome

1 reference

12 December 2020

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

1 reference

12 December 2020

LPS protects macrophages from AIF-independent parthanatos by downregulation of PARP1 expression, induction of SOD2 expression, and a metabolic shift to aerobic glycolysis

1 reference

12 December 2020

To the edge of cell death and back

1 reference

12 December 2020

Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells

1 reference

12 December 2020

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

1 reference

12 December 2020

Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation

1 reference

12 December 2020

Neutrophil pyroptosis: new perspectives on sepsis

1 reference

12 December 2020

Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly

1 reference

12 December 2020

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

1 reference

12 December 2020

Chopping GSDMD: caspase-8 has joined the team of pyroptosis-mediating caspases

1 reference

12 December 2020

10.1016/J.REDOX.2019.101239

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31212216 AND SRC:MED&resulttype=core&format=json

2 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31212216 AND SRC:MED&resulttype=core&format=json

2 May 2020

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