The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1/Nrf2/ARE Signaling Pathway in Chronic Diseases. (Q64987978)

2 July 2019

review article

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title

The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1/Nrf2/ARE Signaling Pathway in Chronic Diseases. (English)

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2 July 2019

author name string

Wenjun Tu

1

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2 July 2019

Hong Wang

2

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2 July 2019

Song Li

3

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2 July 2019

Qiang Liu

4

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2 July 2019

Hong Sha

5

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2 July 2019

publication date

1 June 2019

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2 July 2019

published in

Aging and Disease

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2 July 2019

volume

10

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2 July 2019

issue

3

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2 July 2019

page(s)

637-651

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2 July 2019

The Biology of Oxygen Radicals

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity

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Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease

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Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.

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Diabetes, oxidative stress, and antioxidants: a review

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Keap1 in adhesion complexes

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Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein1 in mouse embryo fibroblasts

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12 December 2020

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

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Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

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Neurodegenerative diseases and oxidative stress

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NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells

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12 December 2020

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

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12 December 2020

Oxidative stress and vascular disease

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12 December 2020

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

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12 December 2020

Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation

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12 December 2020

Low-energy laser irradiation promotes cellular redox activity

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12 December 2020

Low-level laser therapy for wound healing: mechanism and efficacy

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12 December 2020

Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.

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12 December 2020

Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism

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12 December 2020

A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo.

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12 December 2020

p62/SQSTM1: a missing link between protein aggregates and the autophagy machinery

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12 December 2020

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

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12 December 2020

p53 suppresses the Nrf2-dependent transcription of antioxidant response genes.

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12 December 2020

Expression of Nrf2 in neurodegenerative diseases

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12 December 2020

Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: implications for atherosclerosis and preeclampsia

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12 December 2020

Low-level laser irradiation (LLLI) promotes proliferation of mesenchymal and cardiac stem cells in culture

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12 December 2020

Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury

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12 December 2020

Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway

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12 December 2020

Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

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12 December 2020

Anti-inflammatory effects of low-level laser therapy (LLLT) with two different red wavelengths (660 nm and 684 nm) in carrageenan-induced rat paw edema.

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12 December 2020

Regulation of glutathione synthesis

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12 December 2020

The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease

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12 December 2020

Dual roles of Nrf2 in cancer

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12 December 2020

Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production

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12 December 2020

Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway

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12 December 2020

Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice.

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12 December 2020

Oxidative stress-related aging: A role for prostate cancer?

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12 December 2020

Targeting the Nrf2 pathway against cardiovascular disease

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12 December 2020

Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

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12 December 2020

Protection of vascular cells from oxidative stress by proteasome inhibition depends on Nrf2.

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12 December 2020

Mitochondrial generation of free radicals and hypoxic signaling

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12 December 2020

A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

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12 December 2020

Some current insights into oxidative stress

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12 December 2020

The effect of low-level laser irradiation (In-Ga-Al-AsP - 660 nm) on melanoma in vitro and in vivo

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12 December 2020

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

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12 December 2020

A novel kavalactone derivative protects against H2O2-induced PC12 cell death via Nrf2/ARE activation

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12 December 2020

Attenuation of NF-kappaB and activation of Nrf2 signaling by 1,2,4-triazine derivatives, protects neuron-like PC12 cells against apoptosis

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12 December 2020

Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation

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12 December 2020

Oxidative stress, inflammation, and cancer: how are they linked?

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12 December 2020

Effects of low-power laser irradiation (LPLI) at different wavelengths and doses on oxidative stress and fibrogenesis parameters in an animal model of wound healing.

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12 December 2020

Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle

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12 December 2020

Oxidative Stress and Diabetic Complications

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12 December 2020

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

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12 December 2020

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

1 reference

12 December 2020

Heme Oxygenase-1 Protects Human Melanocytes from H2O2-Induced Oxidative Stress via the Nrf2-ARE Pathway

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12 December 2020

Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo.

1 reference

12 December 2020

Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway.

1 reference

12 December 2020

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

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12 December 2020

Low-level laser therapy (LLLT) in human progressive-intensity running: effects on exercise performance, skeletal muscle status, and oxidative stress.

1 reference

12 December 2020

Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress

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12 December 2020

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

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12 December 2020

Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage

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12 December 2020

HMGB1-RAGE regulates muscle satellite cell homeostasis through p38-MAPK- and myogenin-dependent repression of Pax7 transcription.

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12 December 2020

Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity

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12 December 2020

Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance

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12 December 2020

Inhibition of NF-κB nuclear translocation via HO-1 activation underlies α-tocopheryl succinate toxicity.

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12 December 2020

Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents

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12 December 2020

Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation

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12 December 2020

Low-level laser therapy restores the oxidative stress balance in acute lung injury induced by gut ischemia and reperfusion

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12 December 2020

Nrf2 orchestrates fuel partitioning for cell proliferation.

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12 December 2020

Involvement of the Nrf2-proteasome pathway in the endoplasmic reticulum stress response in pancreatic β-cells

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12 December 2020

Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage

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12 December 2020

Low-level laser therapy (808 nm) reduces inflammatory response and oxidative stress in rat tibialis anterior muscle after cryolesion

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12 December 2020

Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome

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12 December 2020

Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice

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12 December 2020

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

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12 December 2020

Toxico-pharmacological perspective of the Nrf2-Keap1 defense system against oxidative stress in kidney diseases

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12 December 2020

Reduction of reactive oxygen species ameliorates metabolism-secretion coupling in islets of diabetic GK rats by suppressing lactate overproduction

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12 December 2020

New player on an old field; the keap1/Nrf2 pathway as a target for treatment of type 2 diabetes and metabolic syndrome

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12 December 2020

CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma

1 reference

12 December 2020

Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination

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12 December 2020

Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes

1 reference

12 December 2020

Carbonyl reductase 1 is an essential regulator of skeletal muscle differentiation and regeneration

1 reference

12 December 2020

Erythropoietin activates Keap1-Nrf2/ARE pathway in rat brain after ischemia

1 reference

12 December 2020

NRF2 plays a protective role in diabetic retinopathy in mice

1 reference

12 December 2020

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

1 reference

12 December 2020

Effect of phototherapy (low-level laser therapy and light-emitting diode therapy) on exercise performance and markers of exercise recovery: a systematic review with meta-analysis.

1 reference

12 December 2020

NRF2-regulation in brain health and disease: implication of cerebral inflammation

1 reference

12 December 2020

Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression

1 reference

12 December 2020

Low-level laser therapy suppresses the oxidative stress-induced glucocorticoids resistance in U937 cells: relevance to cytokine secretion and histone deacetylase in alveolar macrophages.

1 reference

12 December 2020

Physical activity and prostate gene expression in men with low-risk prostate cancer

1 reference

12 December 2020

α-Tocopheryl succinate pre-treatment attenuates quinone toxicity in prostate cancer PC3 cells

1 reference

12 December 2020

Nrf2: bane or blessing in cancer?

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12 December 2020

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

1 reference

12 December 2020

Transcription factors NRF2 and NF-κB are coordinated effectors of the Rho family, GTP-binding protein RAC1 during inflammation

1 reference

12 December 2020

Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stress

1 reference

12 December 2020

Modulation of NRF2 signaling pathway by nuclear receptors: implications for cancer.

1 reference

12 December 2020

Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats

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12 December 2020

Molecular and chemical regulation of the Keap1-Nrf2 signaling pathway.

1 reference

12 December 2020

Low-level laser therapy for traumatic brain injury in mice increases brain derived neurotrophic factor (BDNF) and synaptogenesis

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12 December 2020

Dietary regulation of Keap1/Nrf2/ARE pathway: focus on plant-derived compounds and trace minerals

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12 December 2020

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

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12 December 2020

The Keap1-Nrf2 system and diabetes mellitus

1 reference

12 December 2020

Nicotinamide adenine dinucleotide phosphate oxidase-4-dependent upregulation of nuclear factor erythroid-derived 2-like 2 protects the heart during chronic pressure overload

1 reference

12 December 2020

Oxidative stress: a concept in redox biology and medicine

1 reference

12 December 2020

Biological effects of low level laser therapy

1 reference

12 December 2020

Sulforaphane reduces apoptosis and oncosis along with protecting liver injury-induced ischemic reperfusion by activating the Nrf2/ARE pathway.

1 reference

12 December 2020

Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease

1 reference

12 December 2020

Endoplasmic reticulum stress and Nrf2 signaling in cardiovascular diseases

1 reference

12 December 2020

Chemopreventive role of anthocyanins in atherosclerosis via activation of Nrf2-ARE as an indicator and modulator of redox.

1 reference

12 December 2020

Low-Level Laser Therapy (LLLT) in Dystrophin-Deficient Muscle Cells: Effects on Regeneration Capacity, Inflammation Response and Oxidative Stress

1 reference

12 December 2020

Epigenetic regulation of Keap1-Nrf2 signaling

1 reference

12 December 2020

Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications

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12 December 2020

Role of Polyphenols and Other Phytochemicals on Molecular Signaling

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12 December 2020

Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation

1 reference

12 December 2020

The Role of Oxidative Stress in Neurodegenerative Diseases

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12 December 2020

Nrf2 Weaves an Elaborate Network of Neuroprotection Against Stroke.

1 reference

12 December 2020

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

1 reference

12 December 2020

Nandrolone decanoate and resistance exercise training favor the occurrence of lesions and activate the inflammatory response in the ventral prostate.

1 reference

12 December 2020

Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism

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12 December 2020

Nuclear factor erythroid-derived 2-like 2 (NFE2L2, Nrf2) mediates exercise-induced mitochondrial biogenesis and the anti-oxidant response in mice.

1 reference

12 December 2020

Exercise-induced Nrf2-signaling is impaired in aging

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12 December 2020

Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats

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12 December 2020

DNA methylation by DNMT1 and DNMT3b methyltransferases is driven by the MUC1-C oncoprotein in human carcinoma cells

1 reference

12 December 2020

MUC1-C induces DNA methyltransferase 1 and represses tumor suppressor genes in acute myeloid leukemia

1 reference

12 December 2020

Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters.

1 reference

12 December 2020

Low-level laser therapy (LLLT) does not reduce subcutaneous adipose tissue by local adipocyte injury but rather by modulation of systemic lipid metabolism

1 reference

12 December 2020

Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance.

1 reference

12 December 2020

Nrf2-a Promising Therapeutic Target for Defensing Against Oxidative Stress in Stroke

1 reference

12 December 2020

Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models

1 reference

12 December 2020

Nuclear Factor (Erythroid-Derived 2)-Like 2 and Thioredoxin-1 in Atherosclerosis and Ischemia/Reperfusion Injury in the Heart

1 reference

12 December 2020

Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation.

1 reference

12 December 2020

Safranal prevents rotenone-induced oxidative stress and apoptosis in an in vitro model of Parkinson's disease through regulating Keap1/Nrf2 signaling pathway

1 reference

12 December 2020

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease.

1 reference

12 December 2020

The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment.

1 reference

12 December 2020

Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time.

1 reference

12 December 2020

Controversy about pharmacological modulation of Nrf2 for cancer therapy

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12 December 2020

NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction

1 reference

12 December 2020

The Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases

1 reference

12 December 2020

Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling

1 reference

12 December 2020

The KEAP1-NRF2 System in Cancer

1 reference

12 December 2020

Genetic Variations and mRNA Expression of NRF2 in Parkinson's Disease

1 reference

12 December 2020

Antifatigue Effect of Luteolin-6-C-Neohesperidoside on Oxidative Stress Injury Induced by Forced Swimming of Rats through Modulation of Nrf2/ARE Signaling Pathways

1 reference

12 December 2020

Basic Biology of Oxidative Stress and the Cardiovascular System: Part 1 of a 3-Part Series

1 reference

12 December 2020

A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization

1 reference

12 December 2020

The influence of low level laser irradiation on vascular reactivity.

1 reference

12 December 2020

Effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the PI3K/Akt and Nrf2/ARE signaling pathways.

1 reference

12 December 2020

Mitochondrial redox signaling enables repair of injured skeletal muscle cells

1 reference

12 December 2020

The Role of the Nrf2/ARE Antioxidant System in Preventing Cardiovascular Diseases

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12 December 2020

Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles

1 reference

12 December 2020

Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer's disease.

1 reference

12 December 2020

Modulations of Keap1-Nrf2 signaling axis by TIIA ameliorated the oxidative stress-induced myocardial apoptosis

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12 December 2020

Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349.

1 reference

12 December 2020

Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice

1 reference

12 December 2020

Quercetin and low level laser therapy promote wound healing process in diabetic rats via structural reorganization and modulatory effects on inflammation and oxidative stress.

1 reference

12 December 2020

Nrf2-Keap1 signaling in oxidative and reductive stress

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12 December 2020

Identifiers

DOI

10.14336/AD.2018.0513

1 reference

2 July 2019

PMC publication ID

6538222

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2 July 2019

PubMed publication ID

31165007

1 reference

2 July 2019