The Molecular Basis of G Protein-Coupled Receptor Activation. (Q64987318)

2 July 2019

title

The Molecular Basis of G Protein-Coupled Receptor Activation. (English)

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2 July 2019

G protein-coupled receptor

main subject

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2

Brian K Kobilka

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2 July 2019

author name string

William I Weis

series ordinal

1

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2 July 2019

publication date

1 June 2018

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2 July 2019

number of pages

23

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Annual Review of Biochemistry

inferred from page(s)

published in

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2 July 2019

volume

87

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2 July 2019

page(s)

897-919

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2 July 2019

An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor

cites work

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12 December 2020

The Energy Landscapes and Motions of Proteins

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12 December 2020

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor

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12 December 2020

Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility

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12 December 2020

Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

12 December 2020

Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor

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12 December 2020

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

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12 December 2020

Bicelle crystallization: a new method for crystallizing membrane proteins yields a monomeric bacteriorhodopsin structure

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12 December 2020

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

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12 December 2020

Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor

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12 December 2020

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

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12 December 2020

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

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12 December 2020

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

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12 December 2020

Dynamic personalities of proteins

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12 December 2020

High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation

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12 December 2020

Allostery and cooperativity revisited

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12 December 2020

Crystal structure of opsin in its G-protein-interacting conformation

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12 December 2020

Crystallizing membrane proteins for structure determination: use of lipidic mesophases

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12 December 2020

Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations

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12 December 2020

Concerted interconversion between ionic lock substates of the beta(2) adrenergic receptor revealed by microsecond timescale molecular dynamics

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12 December 2020

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

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12 December 2020

Structure and function of an irreversible agonist-β(2) adrenoceptor complex

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12 December 2020

The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor

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12 December 2020

The structural basis of agonist-induced activation in constitutively active rhodopsin

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12 December 2020

Crystal structure of metarhodopsin II

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12 December 2020

Structure of an agonist-bound human A2A adenosine receptor

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12 December 2020

Two distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptor

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12 December 2020

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

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12 December 2020

Crystal structure of the β2 adrenergic receptor-Gs protein complex

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12 December 2020

Nanobody stabilization of G protein-coupled receptor conformational states

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12 December 2020

Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX.

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12 December 2020

Activation mechanism of the β2-adrenergic receptor

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12 December 2020

Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.

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12 December 2020

Structure and dynamics of the M3 muscarinic acetylcholine receptor

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12 December 2020

Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors

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12 December 2020

The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor

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12 December 2020

Role of detergents in conformational exchange of a G protein-coupled receptor

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12 December 2020

Efficacy of the β₂-adrenergic receptor is determined by conformational equilibrium in the transmembrane region

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12 December 2020

N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor

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12 December 2020

The dynamic process of β(2)-adrenergic receptor activation

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12 December 2020

Molecular signatures of G-protein-coupled receptors

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12 December 2020

Influence of lipid composition on the structural stability of g-protein coupled receptor

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12 December 2020

The role of ligands on the equilibria between functional states of a G protein-coupled receptor

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12 December 2020

Site-directed spin labeling EPR spectroscopy in protein research.

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12 December 2020

β₂-adrenergic receptor activation by agonists studied with ¹⁹F NMR spectroscopy

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12 December 2020

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

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12 December 2020

Multiple conformational selection and induced fit events take place in allosteric propagation.

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12 December 2020

Activation and allosteric modulation of a muscarinic acetylcholine receptor

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12 December 2020

Differences in allosteric communication pipelines in the inactive and active states of a GPCR.

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12 December 2020

Functional dynamics of deuterated β2 -adrenergic receptor in lipid bilayers revealed by NMR spectroscopy

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12 December 2020

Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor

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12 December 2020

Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling

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12 December 2020

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

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12 December 2020

Propagation of conformational changes during μ-opioid receptor activation

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12 December 2020

Structural insights into µ-opioid receptor activation

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12 December 2020

Allosteric regulation of G protein-coupled receptor activity by phospholipids.

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12 December 2020

Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR.

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12 December 2020

Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor

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12 December 2020

Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

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12 December 2020

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

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12 December 2020

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

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12 December 2020

Structure of the adenosine A(2A) receptor bound to an engineered G protein.

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12 December 2020

A mutagenesis and screening strategy to generate optimally thermostabilized membrane proteins for structural studies

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12 December 2020

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

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12 December 2020

β2-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop

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12 December 2020

Nanobodies to Study G Protein-Coupled Receptor Structure and Function

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12 December 2020

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5.

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12 December 2020

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex

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12 December 2020

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

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12 December 2020

Single-molecule analysis of ligand efficacy in β2AR-G-protein activation

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12 December 2020

Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.

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12 December 2020

10.1146/ANNUREV-BIOCHEM-060614-033910

Identifiers

DOI

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2 July 2019

PMC publication ID

6535337

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2 July 2019

PubMed publication ID

29925258

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2 July 2019