Transcriptome Characterization of Matched Primary Breast and Brain Metastatic Tumors to Detect Novel Actionable Targets. (Q64953175)

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3 April 2020

title

Transcriptome Characterization of Matched Primary Breast and Brain Metastatic Tumors to Detect Novel Actionable Targets (English)

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1

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Roisin M. Dwyer

21

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Elspeth Ward

7

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author name string

Nolan Priedigkeit

2

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Ailís Fagan

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Siobhan Purcell

4

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Nicola Cosgrove

5

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Philip J O'Halloran

6

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Sinéad Cocchiglia

8

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Ryan Hartmaier

9

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Carlos A Castro

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Li Zhu

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George C Tseng

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Peter C Lucas

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Shannon L Puhalla

14

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Adam M Brufsky

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Ronald L Hamilton

16

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Aju Mathew

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Jose P Leone

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Ahmed Basudan

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Lance Hudson

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Sudipto Das

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Darran P O'Connor

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Patrick G Buckley

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Michael Farrell

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Arnold D K Hill

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Steffi Oesterreich

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Adrian V Lee

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Leonie S Young

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language of work or name

English

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publication date

1 April 2019

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Journal of the National Cancer Institute

3 April 2020

published in

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volume

111

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issue

4

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page(s)

388-398

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Creative Commons Attribution-NonCommercial 4.0 International

3 April 2020

copyright license

start time

29 June 2018

1 reference

April 2022 Public Data File from Crossref

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1 reference

12 December 2020

CNS metastases in breast cancer

1 reference

12 December 2020

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

1 reference

12 December 2020

RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice.

1 reference

12 December 2020

Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system

1 reference

12 December 2020

Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain

1 reference

12 December 2020

Biological Processes Associated with Breast Cancer Clinical Outcome Depend on the Molecular Subtypes

1 reference

12 December 2020

Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen

1 reference

12 December 2020

Genes that mediate breast cancer metastasis to the brain

1 reference

12 December 2020

Latent bone metastasis in breast cancer tied to Src-dependent survival signals

1 reference

12 December 2020

HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors

1 reference

12 December 2020

Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance.

1 reference

12 December 2020

HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer

1 reference

12 December 2020

Mechanisms of Endocrine Resistance in Breast Cancer

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12 December 2020

Molecular signatures database (MSigDB) 3.0.

1 reference

12 December 2020

Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases

1 reference

12 December 2020

Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies

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12 December 2020

RET, ROS1 and ALK fusions in lung cancer

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12 December 2020

Conversion of epidermal growth factor receptor 2 and hormone receptor expression in breast cancer metastases to the brain.

1 reference

12 December 2020

Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): a single-group phase 2 study

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12 December 2020

Activating HER2 mutations in HER2 gene amplification negative breast cancer

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12 December 2020

GSVA: gene set variation analysis for microarray and RNA-seq data.

1 reference

12 December 2020

Response to Cabozantinib in patients with RET fusion-positive lung adenocarcinomas

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12 December 2020

GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors

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12 December 2020

Targeting mTOR in RET mutant medullary and differentiated thyroid cancer cells.

1 reference

12 December 2020

RET revisited: expanding the oncogenic portfolio

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12 December 2020

Serpins promote cancer cell survival and vascular co-option in brain metastasis

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12 December 2020

DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer

1 reference

12 December 2020

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

1 reference

12 December 2020

Chemotherapy and targeted therapy for women with human epidermal growth factor receptor 2-negative (or unknown) advanced breast cancer: American Society of Clinical Oncology Clinical Practice Guideline.

1 reference

12 December 2020

CEREBEL (EGF111438): A Phase III, Randomized, Open-Label Study of Lapatinib Plus Capecitabine Versus Trastuzumab Plus Capecitabine in Patients With Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer.

1 reference

12 December 2020

The evolutionary history of lethal metastatic prostate cancer

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12 December 2020

Whole-genome characterization of chemoresistant ovarian cancer

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12 December 2020

Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance

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12 December 2020

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

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12 December 2020

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

1 reference

12 December 2020

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.

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12 December 2020

Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers

1 reference

12 December 2020

Adaptation to AI Therapy in Breast Cancer Can Induce Dynamic Alterations in ER Activity Resulting in Estrogen-Independent Metastatic Tumors

1 reference

12 December 2020

Changing molecular profile of brain metastases compared with matched breast primary cancers and impact on clinical outcomes

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12 December 2020

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT.

1 reference

12 December 2020

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

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12 December 2020

Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer

1 reference

12 December 2020

Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases

1 reference

12 December 2020

Gene Expression Profiling of Breast Cancer Brain Metastasis

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12 December 2020

Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis

1 reference

12 December 2020

Cabozantinib for metastatic breast carcinoma: results of a phase II placebo-controlled randomized discontinuation study

1 reference

12 December 2020

Intrinsic Subtype Switching and Acquired ERBB2/HER2 Amplifications and Mutations in Breast Cancer Brain Metastases

1 reference

12 December 2020

Intrinsic Subtypes and Gene Expression Profiles in Primary and Metastatic Breast Cancer.

1 reference

12 December 2020

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.

1 reference

12 December 2020

The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation

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12 December 2020

Exome-capture RNA sequencing of decade-old breast cancers and matched decalcified bone metastases

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12 December 2020

HER kinase inhibition in patients with HER2- and HER3-mutant cancers

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12 December 2020

Identifiers

DOI

10.1093/JNCI/DJY110

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29961873 AND SRC:MED&resulttype=core&format=json

3 April 2020

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3 April 2020

PubMed publication ID

29961873

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