Biological Rationale for Targeting MEK/ERK Pathways in Anti-Cancer Therapy and to Potentiate Tumour Responses to Radiation. (Q64951143)

1 July 2019

review article

4 references

18 January 2021

31 January 2021

8 February 2021

Biological Rationale for Targeting MEK/ERK Pathways in Anti-Cancer Therapy and to Potentiate Tumour Responses to Radiation. (English)

1 reference

1 July 2019

MAP kinase signaling system

main subject

2 references

18 January 2021

31 January 2021

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8 February 2021

Francesco Marampon

1

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1 July 2019

Carmela Ciccarelli

series ordinal

2

1 reference

1 July 2019

Bianca Maria Zani

series ordinal

3

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1 July 2019

language of work or name

English

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publication date

23 May 2019

4 references

1 July 2019

International Journal of Molecular Sciences

18 January 2021

31 January 2021

8 February 2021

4 references

1 July 2019

18 January 2021

31 January 2021

8 February 2021

20

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1 July 2019

issue

10

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1 July 2019

Creative Commons Attribution

copyright license

3 references

18 January 2021

31 January 2021

8 February 2021

0 references

c-myc inhibition of MyoD and myogenin-initiated myogenic differentiation

1 reference

12 December 2020

The 5Rs of radiobiology

1 reference

12 December 2020

Distinctive effects of the viral oncogenes myc, erb, fps, and src on the differentiation program of quail myogenic cells

1 reference

12 December 2020

The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation

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12 December 2020

Cyclic x-ray responses in mammalian cells in vitro

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12 December 2020

Aquired Radioresistance of Tumour Cells

1 reference

12 December 2020

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

12 December 2020

Effects of ionizing radiation on cell cycle progression

1 reference

12 December 2020

The sevenmaker gain-of-function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action

1 reference

12 December 2020

Constitutively active mutants of MAP kinase kinase (MEK1) induce growth factor-relaxation and oncogenicity when expressed in fibroblasts

1 reference

12 December 2020

c-Myc inhibits myogenic differentiation and myoD expression by a mechanism which can be dissociated from cell transformation.

1 reference

12 December 2020

Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein

1 reference

12 December 2020

Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members

1 reference

12 December 2020

Regulation of cell motility by mitogen-activated protein kinase

1 reference

12 December 2020

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

1 reference

12 December 2020

Regulation of Connexin-43 Gap Junctional Intercellular Communication by Mitogen-activated Protein Kinase

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12 December 2020

The intrinsic radiosensitivity of normal and tumour cells

1 reference

12 December 2020

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

1 reference

12 December 2020

Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation.

1 reference

12 December 2020

Irradiation induces G2/M cell cycle arrest and apoptosis in p53-deficient lymphoblastic leukemia cells without affecting Bcl-2 and Bax expression

1 reference

12 December 2020

Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation

1 reference

12 December 2020

Signal transduction and cellular radiation responses

1 reference

12 December 2020

ERK activation upon hypoxia: involvement in HIF-1 activation

1 reference

12 December 2020

c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells

1 reference

12 December 2020

Serine/threonine protein kinases and apoptosis.

1 reference

12 December 2020

Partners and pathwaysrepairing a double-strand break.

1 reference

12 December 2020

The DNA damage response: putting checkpoints in perspective

1 reference

12 December 2020

Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines.

1 reference

12 December 2020

Homologous recombinational repair of DNA ensures mammalian chromosome stability

1 reference

12 December 2020

Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy

1 reference

12 December 2020

Constitutive activation of extracellular signal-regulated kinase 2 by synergistic point mutations

1 reference

12 December 2020

Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory

1 reference

12 December 2020

Mutations of the BRAF gene in human cancer

1 reference

12 December 2020

Responding to hypoxia: lessons from a model cell line

1 reference

12 December 2020

Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction

1 reference

12 December 2020

Stress and radiation-induced activation of multiple intracellular signaling pathways

1 reference

12 December 2020

Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling

1 reference

12 December 2020

Ras pathway signaling on endomembranes

1 reference

12 December 2020

RAS oncogenes: the first 30 years.

1 reference

12 December 2020

MAPK pathways in radiation responses

1 reference

12 December 2020

An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development

1 reference

12 December 2020

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

1 reference

12 December 2020

Essential role for ERK2 mitogen-activated protein kinase in placental development

1 reference

12 December 2020

Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion

1 reference

12 December 2020

Role of cell cycle in mediating sensitivity to radiotherapy

1 reference

12 December 2020

The RAF proteins take centre stage

1 reference

12 December 2020

Subcellular localization determines MAP kinase signal output

1 reference

12 December 2020

The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines

1 reference

12 December 2020

ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis.

1 reference

12 December 2020

The role of erk1 and erk2 in multiple stages of T cell development

1 reference

12 December 2020

A novel role of p38 alpha MAPK in mitotic progression independent of its kinase activity

1 reference

12 December 2020

BRAF mutation predicts sensitivity to MEK inhibition

1 reference

12 December 2020

A mutation in the common docking domain of ERK2 in a human cancer cell line, which was associated with its constitutive phosphorylation

1 reference

12 December 2020

p21WAF1 expression induced by MEK/ERK pathway activation or inhibition correlates with growth arrest, myogenic differentiation and onco-phenotype reversal in rhabdomyosarcoma cells.

1 reference

12 December 2020

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

1 reference

12 December 2020

The MEK/ERK cascade: from signaling specificity to diverse functions

1 reference

12 December 2020

The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity

1 reference

12 December 2020

ERK implication in cell cycle regulation

1 reference

12 December 2020

DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation

1 reference

12 December 2020

Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response

1 reference

12 December 2020

Irradiation-induced G2/M checkpoint response requires ERK1/2 activation

1 reference

12 December 2020

Raf kinases: function, regulation and role in human cancer

1 reference

12 December 2020

The mechanism of human nonhomologous DNA end joining

1 reference

12 December 2020

The epithelial-mesenchymal transition generates cells with properties of stem cells

1 reference

12 December 2020

The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells

1 reference

12 December 2020

Activation of epidermal growth factor receptor and its downstream signaling pathway by nitric oxide in response to ionizing radiation

1 reference

12 December 2020

ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes

1 reference

12 December 2020

ERK2 CD domain mutation from a human cancer cell line enhanced anchorage-independent cell growth and abnormality in Drosophila.

1 reference

12 December 2020

Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype

1 reference

12 December 2020

Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway

1 reference

12 December 2020

Next-generation sequencing: from basic research to diagnostics

1 reference

12 December 2020

Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells

1 reference

12 December 2020

Massively parallel sequencing: the next big thing in genetic medicine

1 reference

12 December 2020

Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport

1 reference

12 December 2020

Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling

1 reference

12 December 2020

MEK1 mutations confer resistance to MEK and B-RAF inhibition

1 reference

12 December 2020

Pathological roles of MAPK signaling pathways in human diseases

1 reference

12 December 2020

Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited

1 reference

12 December 2020

ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events

1 reference

12 December 2020

Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation

1 reference

12 December 2020

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

1 reference

12 December 2020

BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation

1 reference

12 December 2020

ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma-lamin A complexes.

1 reference

12 December 2020

Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K

1 reference

12 December 2020

MEK/ERK inhibitor U0126 increases the radiosensitivity of rhabdomyosarcoma cells in vitro and in vivo by downregulating growth and DNA repair signals

1 reference

12 December 2020

Factors determining DNA double-strand break repair pathway choice in G2 phase

1 reference

12 December 2020

MEK–ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death

1 reference

12 December 2020

Strategies to improve radiotherapy with targeted drugs

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12 December 2020

Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.

1 reference

12 December 2020

Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy

1 reference

12 December 2020

The ERK Cascade: Distinct Functions within Various Subcellular Organelles

1 reference

12 December 2020

Ras in Cancer and Developmental Diseases

1 reference

12 December 2020

Extracellular Signal-Regulated Kinases Modulate DNA Damage Response - A Contributing Factor to Using MEK Inhibitors in Cancer Therapy

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12 December 2020

Specifically targeting ERK1 or ERK2 kills melanoma cells

1 reference

12 December 2020

ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2.

1 reference

12 December 2020

Cancer and radiation therapy: current advances and future directions

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12 December 2020

ERK1/2 MAP kinases: structure, function, and regulation

1 reference

12 December 2020

Reactivation of mitogen-activated protein kinase (MAPK) pathway by FGF receptor 3 (FGFR3)/Ras mediates resistance to vemurafenib in human B-RAF V600E mutant melanoma

1 reference

12 December 2020

Inhibition of ERK activation enhances the repair of double-stranded breaks via non-homologous end joining by increasing DNA-PKcs activation

1 reference

12 December 2020

Sorafenib potentiates irradiation effect in hepatocellular carcinoma in vitro and in vivo.

1 reference

12 December 2020

Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals

1 reference

12 December 2020

Genome-wide kinase-chromatin interactions reveal the regulatory network of ERK signaling in human embryonic stem cells

1 reference

12 December 2020

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

1 reference

12 December 2020

Cancer drug resistance: an evolving paradigm

1 reference

12 December 2020

Ionizing radiation-induced DNA damage, response, and repair.

1 reference

12 December 2020

Close correlation between MEK/ERK and Aurora-B signaling pathways in sustaining tumorigenic potential and radioresistance of gynecological cancer cell lines.

1 reference

12 December 2020

The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma

1 reference

12 December 2020

Mitogen-activated protein kinases and their role in radiation response

1 reference

12 December 2020

Landscape of genomic alterations in cervical carcinomas

1 reference

12 December 2020

Discovery and saturation analysis of cancer genes across 21 tumour types

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12 December 2020

MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors

1 reference

12 December 2020

1 reference

12 December 2020

Metastatic stem cells: sources, niches, and vital pathways

1 reference

12 December 2020

Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1α functional interplay.

1 reference

12 December 2020

Next generation DNA sequencing and the future of genomic medicine

1 reference

12 December 2020

Radiotherapy-induced plasticity of prostate cancer mobilizes stem-like non-adherent, Erk signaling-dependent cells

1 reference

12 December 2020

Cancer stem cells, cancer cell plasticity and radiation therapy

1 reference

12 December 2020

Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma

1 reference

12 December 2020

ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors

1 reference

12 December 2020

Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma.

1 reference

12 December 2020

Detailed imaging and genetic analysis reveal a secondary BRAF(L505H) resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib

1 reference

12 December 2020

Molecular mechanisms involved in tumor repopulation after radiotherapy

1 reference

12 December 2020

Role of HGF/MET axis in resistance of lung cancer to contemporary management

1 reference

12 December 2020

Cavin-1 and Caveolin-1 are both required to support cell proliferation, migration and anchorage-independent cell growth in rhabdomyosarcoma

1 reference

12 December 2020

Signal transduction in cancer

1 reference

12 December 2020

Biological response of cancer cells to radiation treatment

1 reference

12 December 2020

The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence

1 reference

12 December 2020

Trametinib radiosensitises RAS- and BRAF-mutated melanoma by perturbing cell cycle and inducing senescence.

1 reference

12 December 2020

ERK1/2 can feedback-regulate cellular MEK1/2 levels.

1 reference

12 December 2020

Functional Redundancy of ERK1 and ERK2 MAP Kinases during Development

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12 December 2020

Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis.

1 reference

12 December 2020

MEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways

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12 December 2020

Cancer stem cells and signaling pathways in radioresistance

1 reference

12 December 2020

Structural Basis for the Non-catalytic Functions of Protein Kinases.

1 reference

12 December 2020

Dissecting Therapeutic Resistance to ERK Inhibition

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12 December 2020

Cancer stem cells: Radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments

1 reference

12 December 2020

Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population.

1 reference

12 December 2020

c-Myc Sustains Transformed Phenotype and Promotes Radioresistance of Embryonal Rhabdomyosarcoma Cell Lines.

1 reference

12 December 2020

Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer.

1 reference

12 December 2020

A combinatorial strategy for treating KRAS-mutant lung cancer

1 reference

12 December 2020

ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?

1 reference

12 December 2020

Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants

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12 December 2020

The paradox role of caspase cascade in ionizing radiation therapy

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12 December 2020

A compendium of ERK targets

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12 December 2020

The molecular mechanisms of chemoresistance in cancers

1 reference

12 December 2020

Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells.

1 reference

12 December 2020

Molecular testing for BRAF mutations to inform melanoma treatment decisions: a move toward precision medicine

1 reference

12 December 2020

Correction: Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors

1 reference

12 December 2020

Radiation effects on antitumor immune responses: current perspectives and challenges

1 reference

12 December 2020

Extracellular-Regulated Kinases: Signaling From Ras to ERK Substrates to Control Biological Outcomes.

1 reference

12 December 2020

ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy

1 reference

12 December 2020

A Secondary Mutation in Confers Resistance to RAF Inhibition in a -Mutant Brain Tumor

1 reference

12 December 2020

Disruption of MEK/ERK/c-Myc signaling radiosensitizes prostate cancer cells in vitro and in vivo

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12 December 2020

MEK inhibition induces MYOG and remodels super-enhancers in RAS-driven rhabdomyosarcoma

1 reference

12 December 2020

Cancer stem cells: Road to therapeutic resistance and strategies to overcome resistance

1 reference

12 December 2020

ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation

1 reference

12 December 2020

Caveolin-1 enhances metastasis formation in a human model of embryonal rhabdomyosarcoma through Erk signaling cooperation

1 reference

12 December 2020

Identifiers

DOI

10.3390/IJMS20102530

1 reference

1 July 2019

PMC publication ID

6567863

1 reference

1 July 2019

PubMed publication ID

31126017

1 reference

1 July 2019