Systems Biology Approaches to Investigate Genetic and Epigenetic Molecular Progression Mechanisms for Identifying Gene Expression Signatures in Papillary Thyroid Cancer. (Q64927548)

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scientific article published on 23 May 2019

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English	Systems Biology Approaches to Investigate Genetic and Epigenetic Molecular Progression Mechanisms for Identifying Gene Expression Signatures in Papillary Thyroid Cancer.	scientific article published on 23 May 2019

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scholarly article

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6566633

Systems Biology Approaches to Investigate Genetic and Epigenetic Molecular Progression Mechanisms for Identifying Gene Expression Signatures in Papillary Thyroid Cancer. (English)

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6566633

systems biology

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based on heuristic

inferred from title

3

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6566633

author name string

Shan-Ju Yeh

1

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6566633

Chien-Yu Lin

2

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6566633

Bor-Sen Chen

4

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PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6566633

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publication date

23 May 2019

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6566633

International Journal of Molecular Sciences

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6566633

20

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6566633

10

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6566633

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Creative Commons Attribution 4.0 International

23 May 2019

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April 2022 Public Data File from Crossref

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Regulation of activity of the transcription factor GATA-1 by acetylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

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Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

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Overexpression and overactivation of Akt in thyroid carcinoma

1 reference

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12 December 2020

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Lovastatin and extended-release niacin combination product: the first drug combination for the management of hyperlipidemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

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Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

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Promoter methylation of the PTEN gene is a common molecular change in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

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TP53 codon 72 polymorphism in radiation-associated human papillary thyroid cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

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Angiogenesis and lymphangiogenesis in thyroid proliferative lesions: relationship to type and tumour behaviour

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

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https://pubmed.ncbi.nlm.nih.gov/31126066

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Interferon-alpha and cancer: mechanisms of action and new perspectives of clinical use.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

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Network-based classification of breast cancer metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

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Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

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TbetaRIII suppresses non-small cell lung cancer invasiveness and tumorigenicity

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Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection

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https://pubmed.ncbi.nlm.nih.gov/31126066

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Adaptive immune response in JAM-C-deficient mice: normal initiation but reduced IgG memory

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Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors

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https://pubmed.ncbi.nlm.nih.gov/31126066

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Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

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The emerging role of TGF-beta superfamily coreceptors in cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

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Inverse correlation between PDGFC expression and lymphocyte infiltration in human papillary thyroid carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

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Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

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based on heuristic

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TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CCR10 and CCL27 are overexpressed in cutaneous squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

XB130, a novel adaptor protein, promotes thyroid tumor growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Germline PKHD1 mutations are protective against colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression-Based In Silico Screening of Candidate Therapeutic Compounds for Lung Adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRAFV600E and Microenvironment in Thyroid Cancer: A Functional Link to Drive Cancer Progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNAs in thyroid cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TC-PTP dephosphorylates the guanine nucleotide exchange factor C3G (RapGEF1) and negatively regulates differentiation of human neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression, localization, and phosphorylation of Akt1 in benign and malignant thyroid lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ambiguous role of NKX2-5 mutations in thyroid dysgenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

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inferred from PubMed ID database lookup

p55PIK transcriptionally activated by MZF1 promotes colorectal cancer cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complex temporal changes in TGFβ oncogenic signaling drive thyroid carcinogenesis in a mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

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Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGF receptor 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-throughput methods for combinatorial drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of epithelial mesenchymal transition markers in thyroid carcinoma progression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MiR-34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase 2 (HDAC2) protein-dependent deacetylation of mortality factor 4-like 1 (MORF4L1) protein enhances its homodimerization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diverse roles of miR-29 in cancer (review).

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted therapy in gastric cancer: personalizing cancer treatment based on patient genome

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure and substrate specificity of human Cdk12/Cyclin K

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systems biology as an integrated platform for bioinformatics, systems synthetic biology, and systems metabolic engineering

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AHR over-expression in papillary thyroid carcinoma: clinical and molecular assessments in a series of Italian acromegalic patients with a long-term follow-up

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen and its role in thyroid cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of TRAIL-receptor expression by the ubiquitin-proteasome system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic modifications in human thyroid cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 Acetylation: Regulation and Consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD151-A Striking Marker for Cancer Therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a multi-cancer gene expression biomarker for cancer clinical outcomes using a network-based algorithm

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of DLL4 expression in papillary thyroid cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dual role of iNOS in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of somatic mutations of the mTOR gene in differentiated thyroid cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systematic pan-cancer analysis of tumour purity

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation Regulates Functions of ZEB1 Transcription Factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic Profiling of Thyroid Cancer Reveals a Role for Thyroglobulin in Metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CCN family of proteins: critical modulators of the tumor cell microenvironment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAT3-induced WDR1 overexpression promotes breast cancer cell migration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

COSMIC: High-Resolution Cancer Genetics Using the Catalogue of Somatic Mutations in Cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Platelet derived growth factor receptor alpha mediates nodal metastases in papillary thyroid cancer by driving the epithelial-mesenchymal transition

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of miR-27a upregulation on thyroid cancer cells migration, invasion, and angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Mutational Landscape of the Oncogenic MZF1 SCAN Domain in Cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A review of connectivity map and computational approaches in pharmacogenomics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IFNAR1 Degradation: A New Mechanism for Tumor Immune Evasion?

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combination immunotherapy: a road map.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting TGF-β1 suppresses survival of and invasion by anaplastic thyroid carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

miR-133b, a particular member of myomiRs, coming into playing its unique pathological role in human cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High IL-17 expression is associated with an unfavorable prognosis in thyroid cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MiR-130a-3p inhibits the viability, proliferation, invasion, and cell cycle, and promotes apoptosis of nasopharyngeal carcinoma cells by suppressing BACH2 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRAF and NRAS Mutations in Papillary Thyroid Carcinoma and Concordance in BRAF Mutations Between Primary and Corresponding Lymph Node Metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The epigenetic landscape of differentiated thyroid cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Key signaling pathways in thyroid cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum miRNAs as Biomarkers for the Diagnosis and Prognosis of Thyroid Cancer: A Comprehensive Review of the Literature

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD164 promotes lung tumor-initiating cells with stem cell activity and determines tumor growth and drug resistance via Akt/mTOR signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epigenetic Modifications: Novel Therapeutic Approach for Thyroid Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iodine Promotes Tumorigenesis of Thyroid Cancer by Suppressing Mir-422a and Up-Regulating MAPK1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of microRNA let-7b in papillary thyroid carcinoma by regulating HMGA2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functions of actin-interacting protein 1 (AIP1)/WD repeat protein 1 (WDR1) in actin filament dynamics and cytoskeletal regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long noncoding RNAs: emerging players in thyroid cancer pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical significance of miR-34a expression in thyroid diseases - an 18F-FDG PET-CT study

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistochemical Expression of TGF-Β1, SMAD4, SMAD7, TGFβRII and CD68-Positive TAM Densities in Papillary Thyroid Cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NKX2.5 is expressed in papillary thyroid carcinomas and regulates differentiation in thyroid cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A data-driven, knowledge-based approach to biomarker discovery: application to circulating microRNA markers of colorectal cancer prognosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of a gene expression signature and connectivity map to repurpose drugs for bipolar disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/31126066

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/IJMS20102536

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6566633

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6566633

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6566633

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