Hypoxia signaling in human diseases and therapeutic targets. (Q64901322)

30 June 2019

review article

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title

Hypoxia signaling in human diseases and therapeutic targets. (English)

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30 June 2019

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2

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30 June 2019

author name string

Jae W Lee

series ordinal

1

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30 June 2019

Cynthia Ju

series ordinal

3

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30 June 2019

Holger K Eltzschig

series ordinal

4

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30 June 2019

publication date

20 June 2019

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30 June 2019

Experimental and Molecular Medicine

published in

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30 June 2019

volume

51

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30 June 2019

issue

6

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30 June 2019

page(s)

68

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30 June 2019

Mechanism of hypoxia-induced NF-kappaB.

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Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts

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The Hypoxia-Adenosine Link during Intestinal Inflammation.

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Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia

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Adenosine A2A receptor is a unique angiogenic target of HIF-2alpha in pulmonary endothelial cells.

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Coordination of ENT2-dependent adenosine transport and signaling dampens mucosal inflammation

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Current Mechanistic Concepts in Ischemia and Reperfusion Injury.

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Early expression of angiogenesis factors in acute myocardial ischemia and infarction

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Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

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Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury

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7 January 2021

HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation

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7 January 2021

Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning

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7 January 2021

Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors

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7 January 2021

Hypoxia inducible factor-2alpha stabilization and maxi-K channel beta1-subunit gene repression by hypoxia in cardiac myocytes: role in preconditioning

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7 January 2021

Attenuation of myocardial injury by postconditioning: role of hypoxia inducible factor-1alpha

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7 January 2021

Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury.

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7 January 2021

Unfavourable consequences of chronic cardiac HIF-1α stabilization

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7 January 2021

Conditional HIF-1alpha expression produces a reversible cardiomyopathy

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7 January 2021

Carvedilol modulates the expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in a rat model of volume-overload heart failure

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7 January 2021

p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease.

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Heart valve development: endothelial cell signaling and differentiation

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7 January 2021

Hypoxia-mediated regulation of the secretory properties of mitral valve interstitial cells

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7 January 2021

Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak

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7 January 2021

Decreased alveolar oxygen induces lung inflammation

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7 January 2021

Hypoxia signaling during acute lung injury

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7 January 2021

HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium

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7 January 2021

Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury.

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7 January 2021

Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury

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7 January 2021

Hypoxia-Inducible Factor 1α Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury.

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7 January 2021

Deficiency of HIF-1α in myeloid cells protects Escherichia coli or LPS-induced acute lung injury

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

HIF2α signaling inhibits adherens junctional disruption in acute lung injury.

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Molecular pathogenesis of pulmonary arterial hypertension

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7 January 2021

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia

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7 January 2021

Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle hypoxia-inducible factor-1α.

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7 January 2021

Integrating mechanisms of pulmonary fibrosis

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Matrix Remodeling in Pulmonary Fibrosis and Emphysema.

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7 January 2021

Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein

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7 January 2021

Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression.

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7 January 2021

Targeting HIF-1α/PDK1 Axis by Dichloroacetate (DCA) Suppresses Bleomycin-induced Pulmonary Fibrosis

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7 January 2021

HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis

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7 January 2021

Deletion of ADORA2B from myeloid cells dampens lung fibrosis and pulmonary hypertension

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7 January 2021

Effects of Cigarette Smoke on Pulmonary Endothelial Cells

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7 January 2021

Cigarette smoke extract reduces VEGF in primary human airway epithelial cells.

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7 January 2021

Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1α via epidermal growth factor receptor-mediated signaling pathways

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease.

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

MicroRNA-199a-5p Is Associated With Hypoxia-Inducible Factor-1α Expression in Lungs From Patients With COPD

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Protective role of hypoxia-inducible factor-1α-dependent CD39 and CD73 in fulminant acute liver failure.

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Acute acetaminophen intoxication leads to hepatic iron loading by decreased hepcidin synthesis.

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Loss of hypoxia inducible factor-1α aggravates γδ T-cell-mediated inflammation during acetaminophen-induced liver injury.

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Leukocyte adhesion and hepatic microvascular responses to intestinal ischemia/reperfusion in rats

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Pretreatment with mangafodipir improves liver graft tolerance to ischemia/reperfusion injury in rat

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Involvement of the HIF-1α and Wnt/β-catenin pathways in the protective effects of losartan on fatty liver graft with ischaemia/reperfusion injury

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mouse liver ischemia-reperfusion.

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Deficiency of the oxygen sensor PHD1 augments liver regeneration after partial hepatectomy.

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Ischemic postconditioning attenuates liver warm ischemia-reperfusion injury through Akt-eNOS-NO-HIF pathway

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Endogenous A1 adenosine receptors protect against hepatic ischemia reperfusion injury in mice

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Hypoxia-inducible factors as molecular targets for liver diseases

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Pathogenesis of liver cirrhosis

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Reduced liver fibrosis in hypoxia-inducible factor-1alpha-deficient mice

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Role of Hypoxia-Inducible Factors in the Development of Liver Fibrosis

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Hepatocyte Hypoxia Inducible Factor-1 Mediates the Development of Liver Fibrosis in a Mouse Model of Nonalcoholic Fatty Liver Disease

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Hypoxia-Inducible Factor Activation in Myeloid Cells Contributes to the Development of Liver Fibrosis in Cholestatic Mice

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Hypoxia-inducible factor-1α regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

HIF activation protects from acute kidney injury

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Hypoxia-inducible factor activation protects the kidney from gentamicin-induced acute injury

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Repetitive hypoxic preconditioning attenuates renal ischemia/reperfusion induced oxidative injury via upregulating HIF-1 alpha-dependent bcl-2 signaling.

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury.

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Hypoxia-inducible factor-1α promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3.

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Silencing of Hypoxia-Inducible Factor-1α Gene Attenuated Angiotensin II–Induced Renal Injury in Sprague-Dawley Rats

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin.

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

RETRACTED: Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Differential Tissue-Specific Function of Adora2b in Cardioprotection

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

The Devil Is in the Detail: Remote Ischemic Preconditioning for Perioperative Kidney Protection.

1 reference

https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

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https://api.crossref.org/works/10.1038/S12276-019-0235-1

7 January 2021

Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues.

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12 December 2020

Oxygen, oxidative stress, hypoxia, and heart failure

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12 December 2020

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

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12 December 2020

Activation of hypoxia-inducible factor-2 in adipocytes results in pathological cardiac hypertrophy

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12 December 2020

Nuclear factor-κB-hypoxia-inducible factor-2 pathway in aortic valve stenosis

1 reference

12 December 2020

Reduction of hepatic fibrosis by overexpression of von Hippel-Lindau protein in experimental models of chronic liver disease

1 reference

12 December 2020

Endothelial HIF-2α Contributes to Severe Pulmonary Hypertension by Inducing Endothelial-to-Mesenchymal Transition.

1 reference

12 December 2020

Protective effect of sevoflurane on myocardial ischemia-reperfusion injury in rat hearts and its impact on HIF-1α and caspase-3 expression

1 reference

12 December 2020

10.1038/S12276-019-0235-1

Identifiers

DOI

1 reference

30 June 2019

PMC publication ID

6586801

1 reference

30 June 2019

PubMed publication ID

31221962

1 reference

30 June 2019