Local delivery of a viral vector mitigates neutralization by antiviral antibodies and results in efficient transduction of rabbit liver (Q64378421)

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6 January 2020

title

Local delivery of a viral vector mitigates neutralization by antiviral antibodies and results in efficient transduction of rabbit liver (English)

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6 January 2020

author name string

Bradley L Hodges

1

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6 January 2020

Kristin M Taylor

2

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6 January 2020

Qiuming Chu

3

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6 January 2020

Samantha E Scull

4

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6 January 2020

Rebecca G Serriello

5

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6 January 2020

Scott C Anderson

6

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6 January 2020

Fei Wang

7

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6 January 2020

Ronald K Scheule

8

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6 January 2020

language of work or name

English

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publication date

31 August 2005

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6 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16139571 AND SRC:MED&resulttype=core&format=json

6 January 2020

volume

12

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issue

6

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6 January 2020

page(s)

1043-1051

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AAV2 vector harboring a liver-restricted promoter facilitates sustained expression of therapeutic levels of alpha-galactosidase A and the induction of immune tolerance in Fabry mice.

6 January 2020

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Correction of the nonlinear dose response improves the viability of adenoviral vectors for gene therapy of Fabry disease

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Incidence and prevalence of neutralizing antibodies to the common adenoviruses in children with cystic fibrosis: implication for gene therapy with adenovirus vectors

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The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse

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The size of sinusoidal fenestrae is a critical determinant of hepatocyte transduction after adenoviral gene transfer

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Development of catheter-based procedures for transducing the isolated rabbit liver with plasmid DNA.

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Preexisting immunity to adenovirus in rhesus monkeys fails to prevent vector-induced toxicity

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Sustained high-level expression of human factor IX (hFIX) after liver-targeted delivery of recombinant adeno-associated virus encoding the hFIX gene in rhesus macaques

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Selective gene transfer into the liver of non-human primates with E1-deleted, E2A-defective, or E1-E4 deleted recombinant adenoviruses.

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Liver-Directed Gene Transfer in Non-Human Primates

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Sustained expression of therapeutic level of factor IX in hemophilia B dogs by AAV-mediated gene therapy in liver

7 January 2021

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Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons

7 January 2021

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Sustained phenotypic correction of hemophilia B dogs with a factor IX null mutation by liver-directed gene therapy

7 January 2021

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Intravenous administration of recombinant adenoviruses causes thrombocytopenia, anemia and erythroblastosis in rabbits

7 January 2021

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Antibody to CD40 ligand inhibits both humoral and cellular immune responses to adenoviral vectors and facilitates repeated administration to mouse airway

7 January 2021

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Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons

7 January 2021

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A hemodynamic response to intravenous adenovirus vector particles is caused by systemic Kupffer cell-mediated activation of endothelial cells

7 January 2021

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Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

7 January 2021

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Specific depletion of human anti-adenovirus antibodies facilitates transduction in an in vivo model for systemic gene therapy.

7 January 2021

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Circumvention of vector-specific neutralizing antibody response by alternating use of human and non-human adenoviruses: implications in gene therapy

7 January 2021

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Established immunity precludes adenovirus-mediated gene transfer in rat carotid arteries. Potential for immunosuppression and vector engineering to overcome barriers of immunity

7 January 2021

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Oral tolerization to adenoviral proteins permits repeated adenovirus-mediated gene therapy in rats with pre-existing immunity to adenoviruses

7 January 2021

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"Stealth" adenoviruses blunt cell-mediated and humoral immune responses against the virus and allow for significant gene expression upon readministration in the lung

7 January 2021

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Encapsulation of recombinant adenovirus into alginate microspheres circumvents vector-specific immune response

7 January 2021

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Pre-existent adenovirus antibody inhibits systemic toxicity and antitumor activity of CN706 in the nude mouse LNCaP xenograft model: implications and proposals for human therapy

7 January 2021

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7 January 2021

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Identifiers

DOI

10.1016/J.YMTHE.2005.06.475

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16139571 AND SRC:MED&resulttype=core&format=json

6 January 2020

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