Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel (Q64272514)

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22 April 2020

title

Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel (English)

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voltage-gated sodium channel

22 April 2020

main subject

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author

Vladimir Yarov-Yarovoy

5

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22 April 2020

author name string

Phuong T Nguyen

1

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22 April 2020

Kevin R DeMarco

2

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22 April 2020

Igor Vorobyov

3

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22 April 2020

Colleen E Clancy

4

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22 April 2020

language of work or name

English

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publication date

6 February 2019

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Proceedings of the National Academy of Sciences of the United States of America

22 April 2020

published in

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volume

116

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issue

8

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22 April 2020

page(s)

2945-2954

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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

22 April 2020

copyright license

start time

6 February 2019

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence

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Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics.

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Cardiac-specific external paths for lidocaine, defined by isoform-specific residues, accelerate recovery from use-dependent block

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Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na channel alpha subunit in voltage-dependent gating and drug block.

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Common molecular determinants of flecainide and lidocaine block of heart Na channels: evidence from experiments with neutral and quaternary flecainide analogues

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Point mutations at L1280 in Nav1.4 channel D3-S6 modulate binding affinity and stereoselectivity of bupivacaine enantiomers

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State-dependent block of wild-type and inactivation-deficient Na channels by flecainide

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An improved model for the binding of lidocaine and structurally related local anaesthetics to fast-inactivated voltage-operated sodium channels, showing evidence of cooperativity

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12 December 2020

Protein structure prediction using Rosetta

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12 December 2020

A multifunctional aromatic residue in the external pore vestibule of Na channels contributes to the local anesthetic receptor

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Compound-specific Na channel pore conformational changes induced by local anaesthetics

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Scalable molecular dynamics with NAMD

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Identifiers

DOI

10.1073/PNAS.1817446116

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30728299 AND SRC:MED&resulttype=core&format=json

22 April 2020

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22 April 2020

PubMed publication ID

30728299

1 reference