Soluble Heparin and Heparan Sulfate Glycosaminoglycans Interfere with Sonic Hedgehog Solubilization and Receptor Binding (Q64266719)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31018591 AND SRC:MED&resulttype=core&format=json

12 April 2020

title

Soluble Heparin and Heparan Sulfate Glycosaminoglycans Interfere with Sonic Hedgehog Solubilization and Receptor Binding (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31018591 AND SRC:MED&resulttype=core&format=json

heparan sulfate glycosaminoglycan

12 April 2020

main subject

heparin

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1 reference

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31018591 AND SRC:MED&resulttype=core&format=json

12 April 2020

author name string

Dominique Manikowski

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31018591 AND SRC:MED&resulttype=core&format=json

12 April 2020

Petra Jakobs

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31018591 AND SRC:MED&resulttype=core&format=json

12 April 2020

Hamodah Jboor

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31018591 AND SRC:MED&resulttype=core&format=json

12 April 2020

language of work or name

English

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publication date

23 April 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31018591 AND SRC:MED&resulttype=core&format=json

12 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31018591 AND SRC:MED&resulttype=core&format=json

12 April 2020

volume

24

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12 April 2020

issue

8

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Creative Commons Attribution 4.0 International

12 April 2020

page(s)

1607

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copyright license

start time

23 April 2019

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6526471/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

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Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells

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Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions

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Mapping sonic hedgehog-receptor interactions by steric interference

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Cell surface heparan sulfate proteoglycans: selective regulators of ligand-receptor encounters

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Sequencing of 3-O sulfate containing heparin decasaccharides with a partial antithrombin III binding site

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A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube.

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Heparan sulfate: growth control with a restricted sequence menu

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Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein

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Distinct roles of Central missing and Dispatched in sending the Hedgehog signal

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Heparan sulfate proteoglycans as regulators of fibroblast growth factor-2 receptor binding in breast carcinomas

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Heparin inhibition of selectin-mediated interactions during the hematogenous phase of carcinoma metastasis: rationale for clinical studies in humans

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Dynamic regulation of tumor growth and metastasis by heparan sulfate glycosaminoglycans

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Proteoglycans and tumor progression: Janus-faced molecules with contradictory functions in cancer.

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Roles of heparan-sulphate glycosaminoglycans in cancer

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Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling

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Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched

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Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

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The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance

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Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

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12 December 2020

The cholesterol membrane anchor of the Hedgehog protein confers stable membrane association to lipid-modified proteins

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12 December 2020

Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

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12 December 2020

Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning

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12 December 2020

Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities

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12 December 2020

Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway

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12 December 2020

Activation of the hedgehog pathway in advanced prostate cancer

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12 December 2020

Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas

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12 December 2020

Site-specific transformation of Drosophila via phiC31 integrase-mediated cassette exchange

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12 December 2020

Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway

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12 December 2020

Nanoscale organization of hedgehog is essential for long-range signaling

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12 December 2020

A paracrine requirement for hedgehog signalling in cancer

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The ADAM metalloproteinases

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12 December 2020

Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

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12 December 2020

Cancer: Hedgehog's other great trick

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12 December 2020

Minimum FGF2 binding structural requirements of heparin and heparan sulfate oligosaccharides as determined by NMR spectroscopy

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12 December 2020

A small molecule that binds Hedgehog and blocks its signaling in human cells

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12 December 2020

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

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12 December 2020

Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells

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12 December 2020

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

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12 December 2020

SCUBE2 suppresses breast tumor cell proliferation and confers a favorable prognosis in invasive breast cancer

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12 December 2020

The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling

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12 December 2020

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP

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12 December 2020

Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer

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12 December 2020

Paracrine Hedgehog signaling in cancer

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12 December 2020

Hedgehog signalling in colon cancer and stem cells

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12 December 2020

Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site

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12 December 2020

Dual roles of the Cardin-Weintraub motif in multimeric Sonic hedgehog.

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12 December 2020

Sonic hedgehog shedding results in functional activation of the solubilized protein.

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12 December 2020

Heparan sulfate proteoglycans

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12 December 2020

Two distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions

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12 December 2020

Drosophila heparan sulfate, a novel design

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12 December 2020

Heparin and heparan sulfate: analyzing structure and microheterogeneity

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12 December 2020

An emerging role of Sonic hedgehog shedding as a modulator of heparan sulfate interactions

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12 December 2020

Structural insights into proteoglycan-shaped Hedgehog signaling

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12 December 2020

Tumor suppressor SCUBE2 inhibits breast-cancer cell migration and invasion through the reversal of epithelial-mesenchymal transition

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12 December 2020

Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells

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12 December 2020

Signaling domain of Sonic Hedgehog as cannibalistic calcium-regulated zinc-peptidase

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12 December 2020

Blocking Hedgehog release from pancreatic cancer cells increases paracrine signaling potency

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12 December 2020

Sonic hedgehog processing and release are regulated by glypican heparan sulfate proteoglycans

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12 December 2020

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12 December 2020

Bridging the gap: heparan sulfate and Scube2 assemble Sonic hedgehog release complexes at the surface of producing cells.

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Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy

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12 December 2020

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12 December 2020

Construction and characterisation of a heparan sulphate heptasaccharide microarray

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12 December 2020

Hedgehog Signaling: From Basic Biology to Cancer Therapy

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Ca2 coordination controls sonic hedgehog structure and its Scube2-regulated release

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12 December 2020

The Binding Mode of the Sonic Hedgehog Inhibitor Robotnikinin, a Combined Docking and QM/MM MD Study

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12 December 2020

Proteolytic processing of palmitoylated Hedgehog peptides specifies the 3-4 intervein region of the Drosophila wing.

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Structural basis for the recognition of Sonic Hedgehog by human Patched1

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Disrupting Hedgehog Cardin-Weintraub sequence and positioning changes cellular differentiation and compartmentalization in vivo

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12 December 2020

10.3390/MOLECULES24081607

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31018591 AND SRC:MED&resulttype=core&format=json

12 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31018591 AND SRC:MED&resulttype=core&format=json

12 April 2020

PubMed publication ID

31018591

1 reference