Structural Insights into CB1 Receptor Biased Signaling (Q64254283)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31013934 AND SRC:MED&resulttype=core&format=json

12 April 2020

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26 August 2020

Structural Insights into CB1 Receptor Biased Signaling (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31013934 AND SRC:MED&resulttype=core&format=json

12 April 2020

main subject

functional selectivity

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26 August 2020

2

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12 April 2020

author name string

Rufaida Al-Zoubi

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31013934 AND SRC:MED&resulttype=core&format=json

12 April 2020

Patricia H Reggio

series ordinal

3

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12 April 2020

language of work or name

English

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publication date

13 April 2019

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12 April 2020

26 August 2020

International Journal of Molecular Sciences

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12 April 2020

26 August 2020

20

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12 April 2020

issue

8

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Creative Commons Attribution

12 April 2020

page(s)

1837

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copyright license

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26 August 2020

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Molecular cloning of a human cannabinoid receptor which is also expressed in testis

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12 December 2020

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

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12 December 2020

Determination and characterization of a cannabinoid receptor in rat brain

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12 December 2020

Paradoxical action of the cannabinoid WIN 55,212-2 in stimulated and basal cyclic AMP accumulation in rat globus pallidus slices.

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12 December 2020

Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor.

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12 December 2020

Characterization of CB1Cannabinoid Receptors Using Receptor Peptide Fragments and Site-Directed Antibodies

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12 December 2020

Protein Kinase C Disrupts Cannabinoid Actions by Phosphorylation of the CB1 Cannabinoid Receptor

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12 December 2020

Mutation of a highly conserved aspartate residue in the second transmembrane domain of the cannabinoid receptors, CB1 and CB2, disrupts G-protein coupling

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12 December 2020

Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: evidence for agonist-specific trafficking of intracellular responses.

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12 December 2020

Regulation of Gi by the CB1 cannabinoid receptor C-terminal juxtamembrane region: structural requirements determined by peptide analysis

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12 December 2020

Involvement of the carboxyl terminus of the third intracellular loop of the cannabinoid CB1 receptor in constitutive activation of Gs.

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12 December 2020

Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization

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12 December 2020

Internalization and Recycling of the CB1 Cannabinoid Receptor

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12 December 2020

A mutation in the second transmembrane region of the CB1 receptor selectively disrupts G protein signaling and prevents receptor internalization

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12 December 2020

Pharmacology of cannabinoid receptor ligands.

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12 December 2020

Cannabinoid receptors can activate and inhibit G protein-coupled inwardly rectifying potassium channels in a xenopus oocyte expression system.

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12 December 2020

Agonist selective regulation of G proteins by cannabinoid CB(1) and CB(2) receptors

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12 December 2020

The CB(1) cannabinoid receptor juxtamembrane C-terminal peptide confers activation to specific G proteins in brain

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12 December 2020

CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains

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12 December 2020

Structural domains of the CB1 cannabinoid receptor that contribute to constitutive activity and G-protein sequestration.

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12 December 2020

International Union of Pharmacology. XXVII. Classification of cannabinoid receptors

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12 December 2020

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

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12 December 2020

Cannabinoid receptor-G protein interactions: Gαi1-bound structures of IC3 and a mutant with altered G protein specificity

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12 December 2020

(-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens

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12 December 2020

Activation of the cannabinoid CB1 receptor may involve a W6 48/F3 36 rotamer toggle switch

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12 December 2020

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

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12 December 2020

An Aromatic Microdomain at the Cannabinoid CB1 Receptor Constitutes an Agonist/Inverse Agonist Binding Region

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12 December 2020

Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation

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12 December 2020

Chemically distinct ligands promote differential CB1 cannabinoid receptor-Gi protein interactions.

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12 December 2020

CB1 cannabinoid receptor ligands

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12 December 2020

Allosteric modulation of the cannabinoid CB1 receptor

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12 December 2020

The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins.

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12 December 2020

Constitutive activation drives compartment-selective endocytosis and axonal targeting of type 1 cannabinoid receptors.

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12 December 2020

The pharmacology of cannabinoid receptors and their ligands: an overview

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12 December 2020

GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling

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12 December 2020

Mutations of CB1 T210 produce active and inactive receptor forms: correlations with ligand affinity, receptor stability, and cellular localization

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12 December 2020

A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation

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12 December 2020

Changes in the expression of G protein-coupled receptor kinases and beta-arrestins in mouse brain during cannabinoid tolerance: a role for RAS-ERK cascade.

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12 December 2020

The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state.

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12 December 2020

Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro

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12 December 2020

Physiological roles of G protein-coupled receptor kinases and arrestins

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12 December 2020

PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats

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12 December 2020

Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: interspecies differences.

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12 December 2020

Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling.

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12 December 2020

CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a

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12 December 2020

Interaction of a fragment of the cannabinoid CB1 receptor C-terminus with arrestin-2.

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12 December 2020

A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling

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12 December 2020

Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling

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12 December 2020

Regulation of CB1 cannabinoid receptor internalization by a promiscuous phosphorylation-dependent mechanism.

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12 December 2020

High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation

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12 December 2020

Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.

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12 December 2020

Sensitivity to delta9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2 -/- mice

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12 December 2020

Structural analysis of the human cannabinoid receptor one carboxyl-terminus identifies two amphipathic helices.

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12 December 2020

Cannabinoid CB1 receptor-dependent long-term depression in autaptic excitatory neurons

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12 December 2020

In vivo pharmacology of endocannabinoids and their metabolic inhibitors: therapeutic implications in Parkinson's disease and abuse liability

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12 December 2020

Signal transduction of the CB1 cannabinoid receptor

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12 December 2020

Persistent cAMP-signals triggered by internalized G-protein-coupled receptors

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12 December 2020

Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications

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12 December 2020

Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown

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12 December 2020

CB(1) cannabinoid receptors and their associated proteins

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12 December 2020

Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis

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12 December 2020

Binding between a Distal C-Terminus Fragment of Cannabinoid Receptor 1 and Arrestin-2

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12 December 2020

Intracellular cannabinoid type 1 (CB1) receptors are activated by anandamide

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12 December 2020

Crystal structure of the β2 adrenergic receptor-Gs protein complex

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12 December 2020

Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

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12 December 2020

The CB1 cannabinoid receptor C‐terminus regulates receptor desensitization in autaptic hippocampal neurones

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12 December 2020

β-arrestin2 regulates cannabinoid CB1 receptor signaling and adaptation in a central nervous system region-dependent manner

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12 December 2020

Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.

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12 December 2020

Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activation

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12 December 2020

Crystal Structure of a Lipid G Protein–Coupled Receptor

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12 December 2020

Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo

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12 December 2020

Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy

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12 December 2020

CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity.

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12 December 2020

Profiling two indole-2-carboxamides for allosteric modulation of the CB1 receptor.

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12 December 2020

Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding

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12 December 2020

Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor 1 (CB1).

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12 December 2020

Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors

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12 December 2020

Differential β-arrestin2 requirements for constitutive and agonist-induced internalization of the CB1 cannabinoid receptor

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12 December 2020

Cannabinoids increase type 1 cannabinoid receptor expression in a cell culture model of striatal neurons: implications for Huntington's disease

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12 December 2020

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

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12 December 2020

Arrestins as regulators of kinases and phosphatases.

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12 December 2020

Molecular basis of cannabinoid CB1 receptor coupling to the G protein heterotrimer Gαiβγ: identification of key CB1 contacts with the C-terminal helix α5 of Gαi

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12 December 2020

The influence of beta-arrestin2 on cannabinoid CB1 receptor coupling to G-proteins and subcellular localization and relative levels of beta-arrestin1 and 2 in mouse brain

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12 December 2020

Allosteric modulation of a cannabinoid G protein-coupled receptor: binding site elucidation and relationship to G protein signaling

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12 December 2020

Pregnenolone can protect the brain from cannabis intoxication

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12 December 2020

Inhibitory signaling by CB1 receptors in smooth muscle mediated by GRK5/β-arrestin activation of ERK1/2 and Src kinase

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12 December 2020

Mutation of putative GRK phosphorylation sites in the cannabinoid receptor 1 (CB1R) confers resistance to cannabinoid tolerance and hypersensitivity to cannabinoids in mice

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12 December 2020

Allosteric sodium in class A GPCR signaling

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12 December 2020

Characterization of the intrinsic activity for a novel class of cannabinoid receptor ligands: Indole quinuclidine analogs

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12 December 2020

Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons

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12 December 2020

Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1

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12 December 2020

Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1).

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12 December 2020

Mutations in the 'DRY' motif of the CB1 cannabinoid receptor result in biased receptor variants.

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12 December 2020

Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation

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12 December 2020

G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs).

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12 December 2020

The effects of beta-arrestin1 deletion on acute cannabinoid activity, brain cannabinoid receptors and tolerance to cannabinoids in mice.

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12 December 2020

Promising cannabinoid-based therapies for Parkinson's disease: motor symptoms to neuroprotection

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12 December 2020

Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor

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12 December 2020

Structural dynamics and energetics underlying allosteric inactivation of the cannabinoid receptor CB1.

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12 December 2020

Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor

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12 December 2020

Identification of N-arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1 receptors

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12 December 2020

Biased Type 1 Cannabinoid Receptor Signaling Influences Neuronal Viability in a Cell Culture Model of Huntington Disease

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12 December 2020

The pathway of ligand entry from the membrane bilayer to a lipid G protein-coupled receptor

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12 December 2020

SGIP1 alters internalization and modulates signaling of activated cannabinoid receptor 1 in a biased manner

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12 December 2020

The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors

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12 December 2020

Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor

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12 December 2020

Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe

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12 December 2020

Antagonism of Dopamine Receptor 2 Long Affects Cannabinoid Receptor 1 Signaling in a Cell Culture Model of Striatal Medium Spiny Projection Neurons

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12 December 2020

CB1 cannabinoid receptor-mediated increases in cyclic AMP accumulation are correlated with reduced Gi/o function

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12 December 2020

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

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12 December 2020

Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner

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12 December 2020

Crystal Structure of the Human Cannabinoid Receptor CB1.

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12 December 2020

High-resolution crystal structure of the human CB1 cannabinoid receptor

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12 December 2020

Cannabinoid Receptor Interacting Protein 1a Competition with β-Arrestin for CB1 Receptor Binding Sites

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12 December 2020

Pyrimidinyl Biphenylureas: Identification of New Lead Compounds as Allosteric Modulators of the Cannabinoid Receptor CB1.

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12 December 2020

Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease

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12 December 2020

Molecular Targets of the Phytocannabinoids: A Complex Picture

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12 December 2020

Crystal Structure of an LSD-Bound Human Serotonin Receptor

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12 December 2020

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis

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12 December 2020

The DRY motif and the four corners of the cubic ternary complex model.

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12 December 2020

Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfaces

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12 December 2020

Gαs signalling of the CB1 receptor and the influence of receptor number

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12 December 2020

Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities

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12 December 2020

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.

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12 December 2020

CB1 allosteric modulator Org27569 is an antagonist/inverse agonist of ERK1/2 signaling

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12 December 2020

Crystal structures of agonist-bound human cannabinoid receptor CB1.

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12 December 2020

Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.

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12 December 2020

Characterization of Structurally Novel G Protein Biased CB1 Agonists: Implications for Drug Development

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12 December 2020

Allosteric Modulators of the CB1 Cannabinoid Receptor: A Structural Update Review.

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12 December 2020

Assessing the real-time activation of the cannabinoid CB1 receptor and the associated structural changes using a FRET biosensor.

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12 December 2020

The Molecular Basis of G Protein-Coupled Receptor Activation.

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12 December 2020

Cannabidiol skews biased agonism at cannabinoid CB1 and CB2 receptors with smaller effect in CB1-CB2 heteroreceptor complexes

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12 December 2020

Pyrimidinyl Biphenylureas Act as Allosteric Modulators to activate Cannabinoid Receptor 1 and initiate β-Arrestin-dependent Responses

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12 December 2020

Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex

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12 December 2020

Identifiers

DOI

10.3390/IJMS20081837

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31013934 AND SRC:MED&resulttype=core&format=json

12 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31013934 AND SRC:MED&resulttype=core&format=json

12 April 2020

PubMed publication ID

31013934

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