Pathophysiological, Molecular and Therapeutic Issues of Nonalcoholic Fatty Liver Disease: An Overview (Q64249695)

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12 April 2020

title

Pathophysiological, Molecular and Therapeutic Issues of Nonalcoholic Fatty Liver Disease: An Overview (English)

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12 April 2020

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metabolic dysfunction–associated steatotic liver disease

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5

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12 April 2020

Francesco Purrello

6

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12 April 2020

author name string

Simona Marchisello

1

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12 April 2020

Antonino Di Pino

2

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12 April 2020

Roberto Scicali

3

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12 April 2020

Francesca Urbano

4

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12 April 2020

Agata Maria Rabuazzo

7

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12 April 2020

language of work or name

English

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publication date

20 April 2019

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International Journal of Molecular Sciences

12 April 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31010049 AND SRC:MED&resulttype=core&format=json

12 April 2020

volume

20

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12 April 2020

issue

8

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Creative Commons Attribution 4.0 International

12 April 2020

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1948

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copyright license

start time

20 April 2019

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April 2022 Public Data File from Crossref

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copyrighted

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The effect of ezetimibe on NAFLD.

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A comparison of liver fat content as determined by magnetic resonance imaging-proton density fat fraction and MRS versus liver histology in non-alcoholic fatty liver disease.

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Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis

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Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

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Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis

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PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease.

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Statin use and non-alcoholic steatohepatitis in at risk individuals.

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Presence of diabetes mellitus and steatosis is associated with liver stiffness in a general population: The Rotterdam study.

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Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells.

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Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis.

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Steatosis and hepatitis C

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Nonalcoholic Fatty Liver Disease: Dyslipidemia, Risk for Cardiovascular Complications, and Treatment Strategy

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Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups.

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Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study

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Iron overload results in hepatic oxidative stress, immune cell activation, and hepatocellular ballooning injury, leading to nonalcoholic steatohepatitis in genetically obese mice

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Clinical patterns of hepatocellular carcinoma in nonalcoholic fatty liver disease: A multicenter prospective study

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Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism.

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The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage.

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Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

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Time for Glucagon like peptide-1 receptor agonists treatment for patients with NAFLD?

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12 December 2020

Circadian Clock Control of Liver Metabolic Functions

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12 December 2020

Risk factors of metabolic syndrome after liver transplantation.

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12 December 2020

Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice

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12 December 2020

Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis.

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Body Mass Index and Risk of Nonalcoholic Fatty Liver Disease: Two Electronic Health Record Prospective Studies

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Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes.

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Association between Dietary Vitamin C Intake and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study among Middle-Aged and Older Adults

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Innate Immunity and Inflammation in NAFLD/NASH.

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The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

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Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

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Circadian rhythms of liver physiology and disease: experimental and clinical evidence

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12 December 2020

A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease

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12 December 2020

PNPLA3 gene in liver diseases

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12 December 2020

Non-alcoholic steatohepatitis and liver transplantation

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12 December 2020

EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

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12 December 2020

Histology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in Adults and Children

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12 December 2020

Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial

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Insulin Resistance of Puberty.

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12 December 2020

2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by repres

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12 December 2020

Elafibranor for the treatment of NAFLD: One pill, two molecular targets and multiple effects in a complex phenotype

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12 December 2020

Non-alcoholic fatty liver disease and dyslipidemia: An update

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12 December 2020

Effect of exercise on the development of new fatty liver and the resolution of existing fatty liver.

1 reference

12 December 2020

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes

1 reference

12 December 2020

A Guide to Non-Alcoholic Fatty Liver Disease in Childhood and Adolescence

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12 December 2020

Overweight in late adolescence predicts development of severe liver disease later in life: A 39years follow-up study

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12 December 2020

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

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12 December 2020

Moderate Exercise for Nonalcoholic Fatty Liver Disease

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12 December 2020

Association between lipoprotein(a) and nonalcoholic fatty liver disease among Korean adults.

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12 December 2020

Diabetes mellitus and metformin in hepatocellular carcinoma

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12 December 2020

NAFLD and liver transplantation: Current burden and expected challenges

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12 December 2020

Probiotics and Prebiotics

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12 December 2020

Nonobese Fatty Liver Disease

1 reference

12 December 2020

Nonalcoholic fatty liver disease in Asia: emerging perspectives.

1 reference

12 December 2020

NAFLD and diabetes mellitus

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12 December 2020

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

1 reference

12 December 2020

Combined effects of the PNPLA3 rs738409, TM6SF2 rs58542926, and MBOAT7 rs641738 variants on NAFLD severity: a multicenter biopsy-based study

1 reference

12 December 2020

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

1 reference

12 December 2020

Under-prescription of statins in patients with non-alcoholic fatty liver disease.

1 reference

12 December 2020

Amelioration of fatty liver index in patients with type 2 diabetes on ipragliflozin: an association with glucose-lowering effects

1 reference

12 December 2020

Sarcopenia is associated with severe liver fibrosis in patients with non-alcoholic fatty liver disease

1 reference

12 December 2020

The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells

1 reference

12 December 2020

Non-alcoholic fatty liver disease and its treatment with n-3 polyunsaturated fatty acids.

1 reference

12 December 2020

AISF position paper on nonalcoholic fatty liver disease (NAFLD): Updates and future directions

1 reference

12 December 2020

Ezetimibe for the treatment of non-alcoholic fatty liver disease: A meta-analysis

1 reference

12 December 2020

Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study.

1 reference

12 December 2020

The Mediterranean dietary pattern as the diet of choice for non-alcoholic fatty liver disease: Evidence and plausible mechanisms

1 reference

12 December 2020

Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci

1 reference

12 December 2020

NAFLD as a Sexual Dimorphic Disease: Role of Gender and Reproductive Status in the Development and Progression of Nonalcoholic Fatty Liver Disease and Inherent Cardiovascular Risk.

1 reference

12 December 2020

Liver and Cardiovascular Damage in Patients With Lean Nonalcoholic Fatty Liver Disease, and Association With Visceral Obesity.

1 reference

12 December 2020

Lysosomal acid lipase deficiency: a form of non-obese fatty liver disease (NOFLD).

1 reference

12 December 2020

Ultrasonographic fatty liver indicator detects mild steatosis and correlates with metabolic/histological parameters in various liver diseases

1 reference

12 December 2020

Statins: An Under-Appreciated Asset for the Prevention and the Treatment of NAFLD or NASH and the Related Cardiovascular Risk.

1 reference

12 December 2020

The Diagnosis and Management of Nonalcoholic Fatty Liver Disease: Practice Guidance from the American Association for the Study of Liver Diseases.

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12 December 2020

Luseogliflozin improves liver fat deposition compared to metformin in type 2 diabetes patients with non-alcoholic fatty liver disease: A prospective randomized controlled pilot study

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Serial combination of non-invasive tools improves the diagnostic accuracy of severe liver fibrosis in patients with NAFLD.

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Adipokines and Non-Alcoholic Fatty Liver Disease: Multiple Interactions

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A Randomized, Placebo-Controlled Trial of Cenicriviroc for Treatment of Nonalcoholic Steatohepatitis with Fibrosis.

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The ASK1 Inhibitor Selonsertib in Patients with Nonalcoholic Steatohepatitis: A Randomized, Phase 2 Trial

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Postprandial lipemia: factoring in lipemic response for ranking foods for their healthiness

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Non-alcoholic Fatty Liver Disease in Lean Subjects: Characteristics and Implications

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Fructose: A Dietary Sugar in Crosstalk with Microbiota Contributing to the Development and Progression of Non-Alcoholic Liver Disease

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An Overview of Dietary Interventions and Strategies to Optimize the Management of Non-Alcoholic Fatty Liver Disease.

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Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms

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Nonalcoholic fatty liver disease: Evolving paradigms.

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Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence?

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Genetics and epigenetics of NAFLD and NASH: Clinical impact

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Emerging Treatments for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

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Insulin resistance and hyperandrogenism drive steatosis and fibrosis risk in young females with PCOS.

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Non-alcoholic Fatty Liver Disease: A Clinical Update

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New treatment options for lipid-lowering therapy in subjects with type 2 diabetes.

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Nonalcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: A Meta-analysis.

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Regression of Nonalcoholic Fatty Liver Disease with Zinc and Selenium Co-supplementation after Disease Progression in Rats

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12 December 2020

Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver Disease

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12 December 2020

The rs626283 Variant in the MBOAT7 Gene is Associated with Insulin Resistance and Fatty Liver in Caucasian Obese Youth

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Paediatric NAFLD: more than just small adults

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Omega-3 fatty acids and non-alcoholic fatty liver disease: Evidence of efficacy and mechanism of action

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12 December 2020

A Multi-strain Probiotic Reduces the Fatty Liver Index, Cytokines and Aminotransferase levels in NAFLD Patients: Evidence from a Randomized Clinical Trial

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NAFLD risk alleles in PNPLA3, TM6SF2, GCKR, and LYPLAL1 show divergent metabolic effects.

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The Biological Clock: A Pivotal Hub in Non-alcoholic Fatty Liver Disease Pathogenesis.

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Relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in non-alcoholic fatty liver disease: a meta-analysis.

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Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism.

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Ad Libitum Mediterranean and Low-Fat Diets Both Significantly Reduce Hepatic Steatosis: A Randomized Controlled Trial

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Cardiovascular Effects of New Oral Glucose-Lowering Agents: DPP-4 and SGLT-2 Inhibitors.

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Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease.

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Modeling NAFLD Disease Burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030

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Effect of Empagliflozin on Liver Fat in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial (E-LIFT Trial)

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Bile acid metabolism and signaling: potential therapeutic target for nonalcoholic fatty liver disease.

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Metformin and risk of hepatocellular carcinoma in patients with type 2 diabetes

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Effects of dapagliflozin and n-3 carboxylic acids on non-alcoholic fatty liver disease in people with type 2 diabetes: a double-blind randomised placebo-controlled study

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Nonheavy Drinking and Worsening of Noninvasive Fibrosis Markers in Nonalcoholic Fatty Liver Disease: A Cohort Study

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Ad Libitum Mediterranean or Low-Fat Diets as Treatments for Nonalcoholic Fatty Liver Disease?

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Association Between Primary Hypothyroidism and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

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Prebiotic and probiotic treatment of nonalcoholic fatty liver disease: a systematic review and meta-analysis

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Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

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The Role of Vitamin E in the Treatment of NAFLD

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MTP genetic variants associated with non-alcoholic fatty liver in metabolic syndrome patients

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2018 Annual Report of the European Liver Transplant Registry (ELTR) - 50-year evolution of liver transplantation

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Effects of SGLT2 inhibitors on systemic and tissue low-grade inflammation: The potential contribution to diabetes complications and cardiovascular disease

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Cholesteryl Ester Transfer Protein Variant (RS1800777) with Liver Histology in Non-Alcoholic Fatty Liver Disease Patients

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12 December 2020

Obeticholic Acid: A New Era in the Treatment of Nonalcoholic Fatty Liver Disease

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12 December 2020

Randomised clinical trial: emricasan versus placebo significantly decreases ALT and caspase 3/7 activation in subjects with non-alcoholic fatty liver disease

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12 December 2020

Future Perspectives on GLP-1 Receptor Agonists and GLP-1/glucagon Receptor Co-agonists in the Treatment of NAFLD

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Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

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Non-alcoholic fatty liver disease in patients with autoimmune hepatitis

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A round trip from nonalcoholic fatty liver disease to diabetes: molecular targets to the rescue?

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miRNA Signature in NAFLD: A Turning Point for a Non-Invasive Diagnosis

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Effect of sodium-glucose cotransporter type 2 inhibitors on liver fat in patients with type 2 diabetes: hepatic beyond cardiovascular and renal protection?

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Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease

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Current status, problems, and perspectives of non-alcoholic fatty liver disease research

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Among Medicare Patients With Hepatocellular Carcinoma, Non-alcoholic Fatty Liver Disease is the Most Common Etiology and Cause of Mortality

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Time to revise the definition of NAFLD: A purist vision

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Prevalence and Risk Factors of Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Without Steatohepatitis

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Notch and Nonalcoholic Fatty Liver and Fibrosis

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Evaluating the association of serum ferritin and hepatic iron with disease severity in non-alcoholic fatty liver disease

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Identifiers

DOI

10.3390/IJMS20081948

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31010049 AND SRC:MED&resulttype=core&format=json

12 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31010049 AND SRC:MED&resulttype=core&format=json

12 April 2020

PubMed publication ID

31010049

1 reference