Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (Q64240589)

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30 April 2020

title

Aberrant mRNA splicing generates oncogenic RNA isoforms and contributes to the development and progression of cholangiocarcinoma (English)

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alternative mRNA splicing, via spliceosome

30 April 2020

main subject

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4

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30 April 2020

author name string

Juthamas Yosudjai

series ordinal

1

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30 April 2020

Sopit Wongkham

series ordinal

2

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30 April 2020

Siwanon Jirawatnotai

series ordinal

3

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30 April 2020

language of work or name

English

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publication date

25 January 2019

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30 April 2020

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30 April 2020

volume

10

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issue

3

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30 April 2020

page(s)

147-155

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opisthorchis viverrini infestation and endogenous nitrosamines as risk factors for cholangiocarcinoma in thailand

30 April 2020

cites work

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12 December 2020

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis

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TP53 Mutations and mdm2 Protein Overexpression in Cholangiocarcinomas

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Expression of variant CD44 containing variant exon v8-10 in gallbladder cancer

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New p53 mutations in hilar cholangiocarcinoma

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Multiple signal transduction pathways through two prostaglandin E receptor EP3 subtype isoforms expressed in human uterus

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A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma

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Human WISP1v, a member of the CCN family, is associated with invasive cholangiocarcinoma

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Identification of two RNA cis-elements that function to regulate the 5' splice site selection of Bcl-x pre-mRNA in response to ceramide

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RNA repair using spliceosome-mediated RNA trans-splicing

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Aberrant and alternative splicing in cancer

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Increased cell proliferation of mouse fibroblast NIH-3T3 in vitro induced by excretory/secretory product(s) from Opisthorchis viverrini

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Alternatively spliced protein variants as potential therapeutic targets for male infertility and contraception

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Spliceosome-mediated RNA trans-splicing

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Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene

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12 December 2020

Altered gene expression in Opisthorchis viverrini-associated cholangiocarcinoma in hamster model.

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12 December 2020

Correlation of p53 gene mutation and expression of P53 protein in cholangiocarcinoma

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12 December 2020

The gene encoding the splicing factor SF2/ASF is a proto-oncogene

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12 December 2020

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

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Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma

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A new mRNA splice variant coding for the human EP3-I receptor isoform.

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Cholangiocarcinoma: lessons from Thailand

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The regulatory T cell-associated transcription factor FoxP3 is expressed by tumor cells.

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Alternative splicing and disease

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A global view of cancer-specific transcript variants by subtractive transcriptome-wide analysis

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Alternative splicing in lung cancer

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Alternative splicing and tumor progression

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

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The isoforms of the p53 protein

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12 December 2020

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation

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In vivo action of trefoil factor 2 (TFF2) to speed gastric repair is independent of cyclooxygenase.

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WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity

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Anti-tumor activity of splice-switching oligonucleotides

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12 December 2020

Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF.

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12 December 2020

The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

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12 December 2020

Trefoil factors: tumor progression markers and mitogens via EGFR/MAPK activation in cholangiocarcinoma

1 reference

12 December 2020

RNA splicing: disease and therapy

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12 December 2020

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

1 reference

12 December 2020

A novel TFF2 splice variant (ΔEX2TFF2) correlates with longer overall survival time in cholangiocarcinoma

1 reference

12 December 2020

Nek2A contributes to tumorigenic growth and possibly functions as potential therapeutic target for human breast cancer

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12 December 2020

Significance of immunoglobulin G4 (IgG4)-positive cells in extrahepatic cholangiocarcinoma: molecular mechanism of IgG4 reaction in cancer tissue

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12 December 2020

Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression

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12 December 2020

Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms

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12 December 2020

Abnormal expression of the pre-mRNA splicing regulators SRSF1, SRSF2, SRPK1 and SRPK2 in non small cell lung carcinoma

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12 December 2020

The Regulation of Multiple p53 Stress Responses is Mediated through MDM2

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12 December 2020

Prostaglandin E2 promotes liver cancer cell growth by the upregulation of FUSE-binding protein 1 expression

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12 December 2020

Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer

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12 December 2020

Ratio disruption of the ∆133p53 and TAp53 isoform equilibrium correlates with poor clinical outcome in intrahepatic cholangiocarcinoma.

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12 December 2020

CD44v6 expression is related to mesenchymal phenotype and poor prognosis in patients with colorectal cancer

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12 December 2020

Directing HER4 mRNA expression towards the CYT2 isoform by antisense oligonucleotide decreases growth of breast cancer cells in vitro and in vivo

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12 December 2020

CCN4 regulates vascular smooth muscle cell migration and proliferation

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12 December 2020

SF3B1 mutations are associated with alternative splicing in uveal melanoma

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12 December 2020

Phase I pharmacokinetic and pharmacodynamic study of the first-in-class spliceosome inhibitor E7107 in patients with advanced solid tumors.

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12 December 2020

Aberrant alternative splicing is another hallmark of cancer

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12 December 2020

New insights into the molecular pathogenesis of intrahepatic cholangiocarcinoma

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12 December 2020

Review: Alternative Splicing (AS) of Genes As An Approach for Generating Protein Complexity.

1 reference

12 December 2020

A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors

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12 December 2020

Uncovering the role of p53 splice variants in human malignancy: a clinical perspective

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12 December 2020

Examining Nek2 as a better proliferation marker in non-small cell lung cancer prognosis

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12 December 2020

Aberrant regulation of alternative pre-mRNA splicing in hepatocellular carcinoma

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12 December 2020

Splice variant transcripts of the anterior gradient 2 gene as a marker of prostate cancer

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12 December 2020

Cholangiocarcinoma: molecular pathways and therapeutic opportunities

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12 December 2020

SF3B1 mutations constitute a novel therapeutic target in breast cancer

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12 December 2020

PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma

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12 December 2020

CD44v6 promotes β-catenin and TGF-β expression, inducing aggression in ovarian cancer cells

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12 December 2020

Functional repair of p53 mutation in colorectal cancer cells using trans-splicing

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12 December 2020

Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing

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12 December 2020

Trans-splicing repair of mutant p53 suppresses the growth of hepatocellular carcinoma cells in vitro and in vivo

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12 December 2020

The p53 isoform Δ133p53β promotes cancer stem cell potential

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12 December 2020

CD44 regulates cell proliferation, migration, and invasion via modulation of c-Src transcription in human breast cancer cells

1 reference

12 December 2020

Prostaglandin E2 promotes human cholangiocarcinoma cell proliferation, migration and invasion through the upregulation of β-catenin expression via EP3-4 receptor

1 reference

12 December 2020

Targeting the ∆133p53 isoform can restore chemosensitivity in 5-fluorouracil-resistant cholangiocarcinoma cells

1 reference

12 December 2020

PKM2 Promotes Cell Survival and Invasion Under Metabolic Stress by Enhancing Warburg Effect in Pancreatic Ductal Adenocarcinoma

1 reference

12 December 2020

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point

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12 December 2020

PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma

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12 December 2020

Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth

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12 December 2020

Immunohistochemical Study for CD44v6 in Hepatocellular Carcinoma and Cholangiocarcinoma

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12 December 2020

Identification of important long non-coding RNAs and highly recurrent aberrant alternative splicing events in hepatocellular carcinoma through integrative analysis of multiple RNA-Seq datasets.

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12 December 2020

Pro-apoptotic effects of splice-switching oligonucleotides targeting Bcl-x pre-mRNA in human glioma cell lines

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12 December 2020

Molecular genetics and targeted therapeutics in biliary tract carcinoma

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12 December 2020

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage

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12 December 2020

Dysregulation of splicing proteins in head and neck squamous cell carcinoma.

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12 December 2020

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CD44 variant-dependent redox status regulation in liver fluke-associated cholangiocarcinoma: A target for cholangiocarcinoma treatment.

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CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis.

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Upregulation of p27 cyclin-dependent kinase inhibitor and a C-terminus truncated form of p27 contributes to G1 phase arrest

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Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer

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Members of the Cyr61/CTGF/NOV Protein Family: Emerging Players in Hepatic Progenitor Cell Activation and Intrahepatic Cholangiocarcinoma

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Identification of biomarkers of intrahepatic cholangiocarcinoma via integrated analysis of mRNA and miRNA microarray data

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12 December 2020

The p53 isoform delta133p53ß regulates cancer cell apoptosis in a RhoB-dependent manner

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12 December 2020

The Δ133p53 Isoform Reduces Wtp53-induced Stimulation of DNA Pol γ Activity in the Presence and Absence of D4T

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12 December 2020

Effect of NIMA-related kinase 2B on the sensitivity of breast cancer to paclitaxel in vitro and vivo

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12 December 2020

New molecular and immunotherapeutic approaches in biliary cancer.

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12 December 2020

A summary of relationships between alternative splicing and breast cancer

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12 December 2020

Alternative Splicing in Breast Cancer and the Potential Development of Therapeutic Tools.

1 reference

12 December 2020

SF3B1 mutation is a poor prognostic indicator in luminal B and progesterone receptor-negative breast cancer patients

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12 December 2020

An aberrantly spliced isoform of anterior gradient-2, AGR2vH promotes migration and invasion of cholangiocarcinoma cell

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12 December 2020

Identifiers

DOI

10.3892/BR.2019.1188

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30906543 AND SRC:MED&resulttype=core&format=json

30 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30906543 AND SRC:MED&resulttype=core&format=json

30 April 2020

PubMed publication ID

30906543

1 reference