Protein Kinase CK2, a Potential Therapeutic Target in Carcinoma Management (Q64235651)

2

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Yijie Zhu

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Yun Zhou

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Shahid Hussain Soomro

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Hui Fu

Asian Pacific Journal of Cancer Prevention

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language of work or name

English

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publication date

25 January 2019

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13 November 2020

8 February 2021

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13 November 2020

8 February 2021

20

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issue

1

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page(s)

23-32

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cites work

Human casein kinase II subunit alpha: sequence of a processed (pseudo)gene and its localization on chromosome 11.

1 reference

12 December 2020

Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/threonine protein kinases.

1 reference

12 December 2020

Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription

1 reference

12 December 2020

Enhanced casein kinase II activity during mouse embryogenesis. Identification of a 110-kDa phosphoprotein as the major phosphorylation product in mouse embryos and Krebs II mouse ascites tumor cells

1 reference

12 December 2020

Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung

1 reference

12 December 2020

Cloning and expression of genes coding for protein kinase CK2 alpha and beta subunits in zebrafish (Danio rerio).

1 reference

12 December 2020

Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle.

1 reference

12 December 2020

Asymmetric expression of protein kinase CK2 subunits in human kidney tumors

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12 December 2020

Expression of casein kinase 2 during mouse embryogenesis

1 reference

12 December 2020

Association of elevated protein kinase CK2 activity with aggressive behavior of squamous cell carcinoma of the head and neck.

1 reference

12 December 2020

New models of lymphoma in transgenic mice

1 reference

12 December 2020

Elevated protein kinase CK2 activity in chromatin of head and neck tumors: association with malignant transformation.

1 reference

12 December 2020

Cloning, expression and properties of the alpha' subunit of casein kinase 2 from zebrafish (Danio rerio).

1 reference

12 December 2020

Protein kinase CK2 (“casein kinase-2”) and its implication in cell division and proliferation

1 reference

12 December 2020

Protein kinase CK2alpha is a target for the Abl and Bcr-Abl tyrosine kinases

1 reference

12 December 2020

Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor

1 reference

12 December 2020

Murine protein kinase CK2: gene and oncogene

1 reference

12 December 2020

Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit

1 reference

12 December 2020

Antisense oligonucleotides against protein kinase CK2-alpha inhibit growth of squamous cell carcinoma of the head and neck in vitro

1 reference

12 December 2020

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

1 reference

12 December 2020

Protein kinase CK2 signal in neoplasia

1 reference

12 December 2020

Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').

1 reference

12 December 2020

Significance of protein kinase CK2 nuclear signaling in neoplasia.

1 reference

12 December 2020

Response of cancer cells to molecular interruption of the CK2 signal

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12 December 2020

Enhanced casein kinase II (CK II) activity in human lung tumours

1 reference

12 December 2020

Phosphorylation regulates the stability of the regulatory CK2beta subunit

1 reference

12 December 2020

Joining the cell survival squad: an emerging role for protein kinase CK2.

1 reference

12 December 2020

Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis

1 reference

12 December 2020

Direct identification of PTEN phosphorylation sites

1 reference

12 December 2020

Protein kinase CK2: structure, regulation and role in cellular decisions of life and death

1 reference

12 December 2020

Protein kinase CK2 promotes aberrant activation of nuclear factor-kappaB, transformed phenotype, and survival of breast cancer cells.

1 reference

12 December 2020

Disruption of the regulatory beta subunit of protein kinase CK2 in mice leads to a cell-autonomous defect and early embryonic lethality

1 reference

12 December 2020

One-thousand-and-one substrates of protein kinase CK2?

1 reference

12 December 2020

Protein kinase CK2 is required for dorsal axis formation in Xenopus embryos

1 reference

12 December 2020

Casein kinase II alpha subunit and C1-inhibitor are independent predictors of outcome in patients with squamous cell carcinoma of the lung.

1 reference

12 December 2020

2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2.

1 reference

12 December 2020

Casein kinase II (CK2) enhances death-inducing signaling complex (DISC) activity in TRAIL-induced apoptosis in human colon carcinoma cell lines.

1 reference

12 December 2020

Protein kinase CK2 phosphorylates and upregulates Akt/PKB.

1 reference

12 December 2020

The multiple personalities of the regulatory subunit of protein kinase CK2: CK2 dependent and CK2 independent roles reveal a secret identity for CK2beta

1 reference

12 December 2020

The shape of things to come: an emerging role for protein kinase CK2 in the regulation of cell morphology and the cytoskeleton

1 reference

12 December 2020

CK2 as a positive regulator of Wnt signalling and tumourigenesis

1 reference

12 December 2020

Downregulation of CK2 induces apoptosis in cancer cells--a potential approach to cancer therapy

1 reference

12 December 2020

A role for CK2alpha/beta in Xenopus early embryonic development

1 reference

12 December 2020

Multiple myeloma cell survival relies on high activity of protein kinase CK2.

1 reference

12 December 2020

Tetrabromocinnamic Acid (TBCA) and Related Compounds Represent a New Class of Specific Protein Kinase CK2 Inhibitors

1 reference

12 December 2020

Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia.

1 reference

12 December 2020

Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT.

1 reference

12 December 2020

Casein kinase II inhibition induces apoptosis in pancreatic cancer cells

1 reference

12 December 2020

The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic development

1 reference

12 December 2020

Inhibition of casein kinase 2 enhances the death ligand- and natural kiler cell-induced hepatocellular carcinoma cell death

1 reference

12 December 2020

Protein kinase CK2--a key suppressor of apoptosis

1 reference

12 December 2020

Impact of protein kinase CK2 on inhibitor of apoptosis proteins in prostate cancer cells

1 reference

12 December 2020

CIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphorylation and exhibits anticancer properties both in vitro and in vivo

1 reference

12 December 2020

Inhibition of protein kinase CK2 suppresses angiogenesis and hematopoietic stem cell recruitment to retinal neovascularization sites.

1 reference

12 December 2020

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

1 reference

12 December 2020

Combined inhibition of PAK7, MAP3K7 and CK2alpha kinases inhibits the growth of MiaPaCa2 pancreatic cancer cell xenografts

1 reference

12 December 2020

Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer.

1 reference

12 December 2020

Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library

1 reference

12 December 2020

DMAT, an inhibitor of protein kinase CK2 induces reactive oxygen species and DNA double strand breaks.

1 reference

12 December 2020

Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2

1 reference

12 December 2020

Safety and preliminary efficacy data of a novel casein kinase 2 (CK2) peptide inhibitor administered intralesionally at four dose levels in patients with cervical malignancies

1 reference

12 December 2020

Altering PI3K-Akt signalling in zebrafish embryos affects PTEN phosphorylation and gastrulation.

1 reference

12 December 2020

Addiction to protein kinase CK2: a common denominator of diverse cancer cells?

1 reference

12 December 2020

Overexpression of nuclear protein kinase CK2 Beta subunit and prognosis in human gastric carcinoma.

1 reference

12 December 2020

CK2 modulation of NF-kappaB, TP53, and the malignant phenotype in head and neck cancer by anti-CK2 oligonucleotides in vitro or in vivo via sub-50-nm nanocapsules.

1 reference

12 December 2020

Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer

1 reference

12 December 2020

Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia.

1 reference

12 December 2020

Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells

1 reference

12 December 2020

CK2 inhibition induces apoptosis via the ER stress response

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12 December 2020

Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus

1 reference

12 December 2020

Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2

1 reference

12 December 2020

CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy

1 reference

12 December 2020

Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plants

1 reference

12 December 2020

A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway

1 reference

12 December 2020

Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT.

1 reference

12 December 2020

Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2α contributes to human bladder cancer cell survival

1 reference

12 December 2020

Protein kinase CK2α is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes

1 reference

12 December 2020

CK2 Inhibitors Enhance the Radiosensitivity of Human Non-Small Cell Lung Cancer Cells Through Inhibition of Stat3 Activation

1 reference

12 December 2020

Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer

1 reference

12 December 2020

Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90

1 reference

12 December 2020

Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cells

1 reference

12 December 2020

Antitumoral activity of allosteric inhibitors of protein kinase CK2.

1 reference

12 December 2020

CK2 Inhibitor CX-4945 Suppresses DNA Repair Response Triggered by DNA-Targeted Anticancer Drugs and Augments Efficacy: Mechanistic Rationale for Drug Combination Therapy

1 reference

12 December 2020

Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways

1 reference

12 December 2020

Casein kinase 2 inhibition attenuates androgen receptor function and cell proliferation in prostate cancer cells.

1 reference

12 December 2020

Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition.

1 reference

12 December 2020

TF--a novel cell-permeable and selective inhibitor of human protein kinase CK2 induces apoptosis in the prostate cancer cell line LNCaP.

1 reference

12 December 2020

Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells

1 reference

12 December 2020

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

1 reference

12 December 2020

Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ-inducible protein 10 in a casein kinase 2-dependent manner.

1 reference

12 December 2020

Novel players in multiple myeloma pathogenesis: role of protein kinases CK2 and GSK3.

1 reference

12 December 2020

Involvement of PI3K-AKT-mTOR pathway in protein kinase CKII inhibition-mediated senescence in human colon cancer cells.

1 reference

12 December 2020

Overexpressions of CK2β and XIAP are associated with poor prognosis of patients with cholangiocarcinoma

1 reference

12 December 2020

Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia.

1 reference

12 December 2020

Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model

1 reference

12 December 2020

CK2 inhibitor CX4945 induces sequential inactivation of proteins in the signaling pathways related with cell migration and suppresses metastasis of A549 human lung cancer cells

1 reference

12 December 2020

Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma

1 reference

12 December 2020

Protein kinase CK2 inhibition down modulates the NF-κB and STAT3 survival pathways, enhances the cellular proteotoxic stress and synergistically boosts the cytotoxic effect of bortezomib on multiple myeloma and mantle cell lymphoma cells

1 reference

12 December 2020

Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling

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12 December 2020

Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity

1 reference

12 December 2020

Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels

1 reference

12 December 2020

Reduced phosphorylation of Stat3 at Ser-727 mediated by casein kinase 2 - protein phosphatase 2A enhances Stat3 Tyr-705 induced tumorigenic potential of glioma cells

1 reference

12 December 2020

Mechanism and efficacy of sub-50-nm tenfibgen nanocapsules for cancer cell-directed delivery of anti-CK2 RNAi to primary and metastatic squamous cell carcinoma.

1 reference

12 December 2020

Protein kinase CK2 and angiogenesis.

1 reference

12 December 2020

Stable knockdown of protein kinase CK2-alpha (CK2α) inhibits migration and invasion and induces inactivation of hedgehog signaling pathway in hepatocellular carcinoma Hep G2 cells

1 reference

12 December 2020

Protein kinase CK2 inhibition induces cell death via early impact on mitochondrial function.

1 reference

12 December 2020

Helicobacter pylori induces cell migration and invasion through casein kinase 2 in gastric epithelial cells

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12 December 2020

Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cells

1 reference

12 December 2020

Casein kinase 2α regulates glioblastoma brain tumor-initiating cell growth through the β-catenin pathway

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12 December 2020

Synergistic interactions of the anti-casein kinase 2 CIGB-300 peptide and chemotherapeutic agents in lung and cervical preclinical cancer models

1 reference

12 December 2020

Apigenin inhibits HeLa sphere-forming cells through inactivation of casein kinase 2α.

1 reference

12 December 2020

Apigenin inhibits the self-renewal capacity of human ovarian cancer SKOV3‑derived sphere-forming cells

1 reference

12 December 2020

JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells

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12 December 2020

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12 December 2020

Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth

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12 December 2020

MEK inhibitor PD-0325901 overcomes resistance to CK2 inhibitor CX-4945 and exhibits anti-tumor activity in head and neck cancer

1 reference

12 December 2020

Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy

1 reference

12 December 2020

Optimizing CIGB-300 intralesional delivery in locally advanced cervical cancer

1 reference

12 December 2020

Tenfibgen-DMAT Nanocapsule Delivers CK2 Inhibitor DMAT to Prostate Cancer Xenograft Tumors Causing Inhibition of Cell Proliferation

1 reference

12 December 2020

Identification of a novel potent, selective and cell permeable inhibitor of protein kinase CK2 from the NIH/NCI Diversity Set Library

1 reference

12 December 2020

Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.

1 reference

12 December 2020

Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma

1 reference

12 December 2020

A Synthetic Lethality Screen Using a Focused siRNA Library to Identify Sensitizers to Dasatinib Therapy for the Treatment of Epithelial Ovarian Cancer

1 reference

12 December 2020

Quinalizarin, a specific CK2 inhibitor, reduces cell viability and suppresses migration and accelerates apoptosis in different human lung cancer cell lines.

1 reference

12 December 2020

Protein Kinase CK2α Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2α Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma

1 reference

12 December 2020

Examination of CK2α and NF-κB p65 expression in human benign prostatic hyperplasia and prostate cancer tissues

1 reference

12 December 2020

CK2 targeted RNAi therapeutic delivered via malignant cell-directed tenfibgen nanocapsule: dose and molecular mechanisms of response in xenograft prostate tumors.

1 reference

12 December 2020

Casein Kinase II (CK2) as a Therapeutic Target for Hematological Malignancies

1 reference

12 December 2020

CK2α/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients

1 reference

12 December 2020

Simultaneous blockade of interacting CK2 and EGFR pathways by tumor-targeting nanobioconjugates increases therapeutic efficacy against glioblastoma multiforme.

1 reference

12 December 2020