A Novel Dipeptide NGF Mimetic GK-2 Selectively Activating the PI3K/AKT Signaling Pathway Promotes the Survival of Pancreatic β-Cells in a Rat Model of Diabetes (Q64232987)

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scientific article published on 01 January 2019

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English	A Novel Dipeptide NGF Mimetic GK-2 Selectively Activating the PI3K/AKT Signaling Pathway Promotes the Survival of Pancreatic β-Cells in a Rat Model of Diabetes	scientific article published on 01 January 2019

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31024748 AND SRC:MED&resulttype=core&format=json

23 April 2020

A Novel Dipeptide NGF Mimetic GK-2 Selectively Activating the PI3K/AKT Signaling Pathway Promotes the Survival of Pancreatic β-Cells in a Rat Model of Diabetes (English)

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23 April 2020

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23 April 2020

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R U Ostrovskaya

1

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23 April 2020

T A Gudasheva

3

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23 April 2020

S B Seredenin

4

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23 April 2020

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1 January 2019

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23 April 2020

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23 April 2020

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23 April 2020

1

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23 April 2020

48-57

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23 April 2020

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo presence of the high affinity nerve growth factor receptor Trk-A in the rat pancreas: differential localization during pancreatic development

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

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STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells

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https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor induces neuron-like differentiation of an insulin-secreting pancreatic beta cell line

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https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

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Pancreatic beta cells synthesize and secrete nerve growth factor

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https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

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Neurotrophin signal transduction in the nervous system

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https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

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Nerve growth factor increases insulin secretion and barium current in pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of AMP-activated protein kinase in mechanism of metformin action

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NGF-withdrawal induces apoptosis in pancreatic beta cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

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The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological roles of glycogen synthase kinase-3: potential as a therapeutic target for diabetes and other disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systematic Review: Comparative Effectiveness and Safety of Oral Medications for Type 2 Diabetes Mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of beta-cell mass and function by the Akt/protein kinase B signalling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ghrelin affects carbohydrate-glycogen metabolism via insulin inhibition and glucagon stimulation in the zebrafish (Danio rerio) brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Persistent correction of hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice by a non-conventional radical scavenger

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel low-molecular-weight mimetics of the nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The lighter side of BDNF

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In Vitro Study of Neuroprotective Properties of GK-2, a New Original Nerve Growth Factor Mimetic

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Gsk3β activity improves β-cell function in c-Kit male mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effect of GK-2, a dipeptide mimetic of nerve growth factor, during experimental focal ischemia in middle cerebral artery basin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiparkinsonian properties of a nerve growth factor dipeptide mimetic GK-2 in in vivo experiments

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor: from the early discoveries to the potential clinical use

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antihyperglykämische Therapie bei Diabetes mellitus Typ 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retracted: Diabetes and Overexpression of proNGF Cause Retinal Neurodegeneration via Activation of RhoA Pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Original nerve growth factor mimetic dipeptide GK-2 limits the manifestations of hemorrhagic stroke in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanism of action of metformin: old or new insights?

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Original Nerve Growth Factor Mimetic Dipeptide GK-2 Restores Impaired Cognitive Functions in Rat Models of Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain-derived neurotrophic factor plasma levels: relationship with dementia and diabetes in the elderly population.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noopept normalizes parameters of the incretin system in rats with experimental diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulating the beta cell mass as a strategy for type-2 diabetes treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An updated review on cancer risk associated with incretin mimetics and enhancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

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Effect of metformin on Schwann cells under hypoxia condition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[The development of a pharmacologically active low-molecular mimetic of the nerve growth factor].

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of p‑Akt by glial cell line‑derived neurotrophic factor ameliorates cell apoptosis in the hippocampus of rats with streptozotocin‑induced diabetic encephalopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Challenges and issues with streptozotocin-induced diabetes - A clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exciting Times for Pancreatic Islets: Glutamate Signaling in Endocrine Cells

1 reference

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12 December 2020

based on heuristic

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Brain-derived neurotrophic factor and its clinical implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ischemic Stroke and Its Risk Factors in a Registry-Based Large Cross-Sectional Diabetic Cohort in a Country Facing a Diabetes Epidemic

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin signalling in Alzheimer's disease and diabetes: from epidemiology to molecular links.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metformin attenuates hepatic insulin resistance in type-2 diabetic rats through PI3K/Akt/GLUT-4 signalling independent to bicuculline-sensitive GABAA receptor stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptide Mimetic of the Brain-derived Neurotrophic Factor Prevents Impairments of Neurogenesis in Stressed Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low-Molecular-Weight NGF Mimetic Corrects the Cognitive Deficit and Depression-like Behavior in Experimental Diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antidiabetic Properties of Low-Molecular-Weight BDNF Mimetics Depend on the Type of Activation of Post-Receptor Signaling Pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/31024748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31024748 AND SRC:MED&resulttype=core&format=json

23 April 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31024748 AND SRC:MED&resulttype=core&format=json

23 April 2020

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