Cardiac Specific Knockout of p53 Decreases ER Stress-Induced Mitochondrial Damage (Q64228403)

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27 April 2020

title

Cardiac Specific Knockout of p53 Decreases ER Stress-Induced Mitochondrial Damage (English)

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Mitochondrial respiratory chain complex I

27 April 2020

main subject

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4

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27 April 2020

author name string

Qun Chen

1

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27 April 2020

Jeremy Thompson

2

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27 April 2020

Ying Hu

3

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27 April 2020

Edward J Lesnefsky

5

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27 April 2020

language of work or name

English

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publication date

19 February 2019

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Frontiers in cardiovascular medicine

27 April 2020

published in

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volume

6

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27 April 2020

page(s)

10

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Creative Commons Attribution 4.0 International

27 April 2020

copyright license

start time

19 February 2019

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Myocardial ischemia decreases oxidative phosphorylation through cytochrome oxidase in subsarcolemmal mitochondria

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12 December 2020

p53 activates the mitochondrial death pathway and apoptosis of ventricular myocytes independent of de novo gene transcription

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12 December 2020

Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway

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12 December 2020

Mitochondrial formation of reactive oxygen species

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12 December 2020

Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling.

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12 December 2020

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

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12 December 2020

Bcl-2 family members and apoptosis, taken to heart

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12 December 2020

Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion.

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12 December 2020

PUMA is critical for neonatal cardiomyocyte apoptosis induced by endoplasmic reticulum stress

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12 December 2020

Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases

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12 December 2020

Signal integration in the endoplasmic reticulum unfolded protein response

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12 December 2020

Characteristics of mitochondrial calpains.

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12 December 2020

Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis

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12 December 2020

Heart mitochondria: gates of life and death

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12 December 2020

Effect of acidic reperfusion on prolongation of intracellular acidosis and myocardial salvage.

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12 December 2020

Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria

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12 December 2020

Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation

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12 December 2020

Structural and functional link between the mitochondrial network and the endoplasmic reticulum

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12 December 2020

Novel O-palmitolylated beta-E1 subunit of pyruvate dehydrogenase is phosphorylated during ischemia/reperfusion injury

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12 December 2020

Blockade of electron transport during ischemia preserves bcl-2 and inhibits opening of the mitochondrial permeability transition pore

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12 December 2020

Mitochondrial-targeted Signal transducer and activator of transcription 3 (STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species

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12 December 2020

Apoptosis in Heart Failure - The Role of the .BETA.-Adrenergic Receptor-Mediated Signaling Pathway and p53-Mediated Signaling Pathway in the Apoptosis of Cardiomyocytes -

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12 December 2020

RETRACTED: Thapsigargin triggers cardiac contractile dysfunction via NADPH oxidase-mediated mitochondrial dysfunction: Role of Akt dephosphorylation

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12 December 2020

Activation of mitochondrial μ-calpain increases AIF cleavage in cardiac mitochondria during ischemia-reperfusion

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12 December 2020

Back to your heart: ubiquitin proteasome system-regulated signal transduction

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12 December 2020

Tissue-specific splicing of an Ndufs6 gene-trap insertion generates a mitochondrial complex I deficiency-specific cardiomyopathy

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12 December 2020

Pyridine nucleotide regulation of cardiac intermediary metabolism

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12 December 2020

Coping with endoplasmic reticulum stress in the cardiovascular system

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12 December 2020

Reduced expression of mitochondrial electron transport chain proteins from hibernating hearts relative to ischemic preconditioned hearts in the second window of protection

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12 December 2020

Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

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12 December 2020

Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure

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12 December 2020

Activation of NADPH oxidase 4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the protein kinase RNA-activated-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α/activating trans

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12 December 2020

MAM (mitochondria-associated membranes) in mammalian cells: lipids and beyond

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12 December 2020

Heart failure and loss of metabolic control

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12 December 2020

Mammalian target of rapamycin (mTOR) inhibition with rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative stress and altered contractile protein expression.

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12 December 2020

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility

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12 December 2020

CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2

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12 December 2020

Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury

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12 December 2020

Reversible blockade of complex I or inhibition of PKCβ reduces activation and mitochondria translocation of p66Shc to preserve cardiac function after ischemia

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12 December 2020

p53 at the endoplasmic reticulum regulates apoptosis in a Ca2 -dependent manner

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12 December 2020

Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation

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12 December 2020

Heart mitochondria and calpain 1: Location, function, and targets

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12 December 2020

Pyruvate dehydrogenase as a therapeutic target for obesity cardiomyopathy

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12 December 2020

Activation of mitochondrial calpain and increased cardiac injury: beyond AIF release.

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12 December 2020

Disruption of calcium transfer from ER to mitochondria links alterations of mitochondria-associated ER membrane integrity to hepatic insulin resistance.

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12 December 2020

Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress

1 reference

12 December 2020

CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced β-Cell Apoptosis

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12 December 2020

Mitochondrial Metabolism in Aging Heart

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12 December 2020

Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies

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12 December 2020

Endoplasmic reticulum proteostasis impairment in aging

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12 December 2020

The Role of Endoplasmic Reticulum Stress in Cardiovascular Disease and Exercise.

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12 December 2020

Metformin attenuates ER stress-induced mitochondrial dysfunction

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12 December 2020

Loss of Metabolic Flexibility in the Failing Heart.

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12 December 2020

Genetic depletion of p53 attenuates cocaine-induced hepatotoxicity in mice

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12 December 2020

Identifiers

DOI

10.3389/FCVM.2019.00010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30838215 AND SRC:MED&resulttype=core&format=json

27 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30838215 AND SRC:MED&resulttype=core&format=json

27 April 2020

PubMed publication ID

30838215

1 reference