Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12 (Q64112827)

3

Rainer H. Kohler

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Mikael Pittet

23

Mikael J. Pittet

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Gordon J. Freeman

11

Gordon J. Freeman

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Christopher S Garris

1

Christopher S. Garris

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Sean P Arlauckas

2

Sean P. Arlauckas

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Camilla Engblom

7

Camilla Engblom

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Marie Siwicki

9

Marie Siwicki

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Jeremy Gungabeesoon

10

Jeremy Gungabeesoon

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Christina Pfirschke

8

Christina Pfirschke

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Seth B Garren

5

Seth Garren

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author name string

Marcel P. Trefny

4

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Cécile Piot

6

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Sarah E. Warren

12

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SuFey Ong

13

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Erica Browning

14

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Christopher G. Twitty

15

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Robert H. Pierce

16

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Mai H. Le

17

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Alain P. Algazi

18

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Adil I. Daud

19

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Sara I. Pai

20

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Alfred Zippelius

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production

21

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publication date

December 2018

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published in

Immunity

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volume

49

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issue

6

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page(s)

1148-1161.e7

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cites work

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The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells

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Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

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A novel transcription factor, T-bet, directs Th1 lineage commitment

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Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming

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Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation.

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Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8 T cell differentiation

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Inflammation directs memory precursor and short-lived effector CD8( ) T cell fates via the graded expression of T-bet transcription factor

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PD-1 and its ligands in tolerance and immunity

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12 December 2020

Dendritic cells require the NF-kappaB2 pathway for cross-presentation of soluble antigens

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12 December 2020

Batf3 Deficiency Reveals a Critical Role for CD8 Dendritic Cells in Cytotoxic T Cell Immunity

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12 December 2020

Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma

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12 December 2020

Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion

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12 December 2020

CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans

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12 December 2020

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8 T cell responses during chronic infection.

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12 December 2020

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12 December 2020

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage

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Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

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Progenitor and terminal subsets of CD8 T cells cooperate to contain chronic viral infection.

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Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.

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The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures

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Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFN-γ receptor subunit 1 (IFNGR1).

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Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582).

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Imaging macrophages with nanoparticles

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Interleukin 12: still a promising candidate for tumor immunotherapy?

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Organization of the mouse and human DC network

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12 December 2020

Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8( ) T cells directly within the tumor microenvironment

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12 December 2020

Macrophage IL-10 blocks CD8 T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells

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12 December 2020

Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity

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12 December 2020

Molecular and genetic properties of tumors associated with local immune cytolytic activity

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A novel model for IFN-γ-mediated autoinflammatory syndromes.

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12 December 2020

Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

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Spatial reconstruction of single-cell gene expression data

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Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

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Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

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12 December 2020

FcγRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1/PD-L1 Axis

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Dendritic cells require NIK for CD40-dependent cross-priming of CD8 T cells

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Expansion and Activation of CD103( ) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition.

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CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer

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The role of myeloid cells in cancer therapies

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Agonistic CD40 mAb-Driven IL12 Reverses Resistance to Anti-PD1 in a T-cell-Rich Tumor.

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T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.

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Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.

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12 December 2020

T-cell invigoration to tumour burden ratio associated with anti-PD-1 response.

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12 December 2020

In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy

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12 December 2020

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity.

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12 December 2020

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12 December 2020

Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity

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12 December 2020

IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment

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12 December 2020

Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer

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12 December 2020

Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab

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Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

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12 December 2020

Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

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MHC-I Genotype Restricts the Oncogenic Mutational Landscape

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SPRING: a kinetic interface for visualizing high dimensional single-cell expression data

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The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients.

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12 December 2020

TIM-3 Regulates CD103 Dendritic Cell Function and Response to Chemotherapy in Breast Cancer

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12 December 2020

Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity

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12 December 2020

Recording the wild lives of immune cells

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12 December 2020