Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective (Q64110642)

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Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective (English)

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cell- and tissue-based therapy

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Catharien M. Hilkens

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Eva Martínez-Cáceres

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Piotr Trzonkowski

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Edward K Geissler

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Anja Ten Brinke

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Marc Martinez-Llordella

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S Marieke van Ham

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Birgit Sawitzki

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Giovanna Lombardi

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22 February 2019

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Frontiers in Immunology

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Creative Commons Attribution 4.0 International

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27 October 2020

"Infectious" transplantation tolerance.

2 May 2021

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Monotherapy rapamycin allows an increase of CD4 CD25 FoxP3 T cells in renal recipients.

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First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4 CD25 CD127- T regulatory cells

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Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway

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Identification of a B cell signature associated with renal transplant tolerance in humans.

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Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis.

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Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses

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Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

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Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

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Alloantigen specific deletion of primary human T cells by Fas ligand (CD95L)‐transduced monocyte‐derived killer‐dendritic cells

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The time is crucial for ex vivo expansion of T regulatory cells for therapy

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Mechanism of cellular rejection in transplantation

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Mechanisms of donor-specific tolerance in recipients of haploidentical combined bone marrow/kidney transplantation.

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Comparative study of clinical grade human tolerogenic dendritic cells

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Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients.

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Specific T-cell proliferation to myelin peptides in relapsing-remitting multiple sclerosis

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Regulatory T cells in stem cell transplantation: strategies and first clinical experiences.

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Cutting Edge: Immunological Consequences and Trafficking of Human Regulatory Macrophages Administered to Renal Transplant Recipients

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12 December 2020

In vivo SPECT reporter gene imaging of regulatory T cells.

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12 December 2020

Differential effects of monophosphoryl lipid A and cytokine cocktail as maturation stimuli of immunogenic and tolerogenic dendritic cells for immunotherapy

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12 December 2020

Interleukin-2 and regulatory T cells in graft-versus-host disease

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12 December 2020

Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation

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12 December 2020

IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction — A comparative study of human clinical-applicable DC

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12 December 2020

Stable antigen-specific T-cell hyporesponsiveness induced by tolerogenic dendritic cells from multiple sclerosis patients

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12 December 2020

Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function

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12 December 2020

Administration of CD4 CD25highCD127- regulatory T cells preserves β-cell function in type 1 diabetes in children

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Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease

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Differing effects of rapamycin or calcineurin inhibitor on T-regulatory cells in pediatric liver and kidney transplant recipients

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Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4( )CD25( )FOXP3( ) T regulatory cell subpopulations

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Fas-independent T-cell apoptosis by dendritic cells controls autoimmune arthritis in MRL/lpr mice

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12 December 2020

The ONE Study compares cell therapy products in organ transplantation: introduction to a review series on suppressive monocyte-derived cells

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Alternative approaches to myeloid suppressor cell therapy in transplantation: comparing regulatory macrophages to tolerogenic DCs and MDSCs

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Impact of culture medium on CD4( ) CD25(high)CD127(lo/neg) Treg expansion for the purpose of clinical application.

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Regulatory multitasking of tolerogenic dendritic cells - lessons taken from vitamin d3-treated tolerogenic dendritic cells

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Antigen-specific tolerance by autologous myelin peptide-coupled cells: a phase 1 trial in multiple sclerosis

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12 December 2020

Regulatory dendritic cell infusion prolongs kidney allograft survival in nonhuman primates

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Adoptive transfer of umbilical cord blood-derived regulatory T cells and early viral reactivation

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Treatment of graft-versus-host disease with naturally occurring T regulatory cells

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A mouse model of adoptive immunotherapeutic targeting of autoimmune arthritis using allo-tolerogenic dendritic cells

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Immunological Outcome in Haploidentical-HSC Transplanted Patients Treated with IL-10-Anergized Donor T Cells

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Immunology: A tolerant approach

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TGF-β signaling initiated in dendritic cells instructs suppressive effects on Th17 differentiation at the site of neuroinflammation

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Tolerogenic dendritic cells and their applications in transplantation

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Beneficial effect of tolerogenic dendritic cells pulsed with MOG autoantigen in experimental autoimmune encephalomyelitis.

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Adoptive transfer of allogeneic regulatory T cells into patients with chronic graft-versus-host disease

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Skewing dendritic cell differentiation towards a tolerogenic state for recovery of tolerance in rheumatoid arthritis.

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Pre-transplant donor-specific T-cell alloreactivity is strongly associated with early acute cellular rejection in kidney transplant recipients not receiving T-cell depleting induction therapy

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The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases

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Human CD45RA(-) FoxP3(hi) Memory-Type Regulatory T Cells Show Distinct TCR Repertoires With Conventional T Cells and Play an Important Role in Controlling Early Immune Activation.

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Use of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetes

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Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients

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12 December 2020

Intraperitoneal Administration of Autologous Tolerogenic Dendritic Cells for Refractory Crohn's Disease: A Phase I Study

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12 December 2020

Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus

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12 December 2020

Hurdles in therapy with regulatory T cells

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12 December 2020

PDGF upregulates CLEC-2 to induce T regulatory cells

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12 December 2020

Biomaterial Strategies for Immunomodulation.

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12 December 2020

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

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12 December 2020

Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells

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12 December 2020

Standardized Multi-Color Flow Cytometry and Computational Biomarker Discovery

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12 December 2020

Gene Expression Profiling of Human Monocyte-derived Dendritic Cells - Searching for Molecular Regulators of Tolerogenicity

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12 December 2020

Hepatic Infiltrates in Operational Tolerant Patients After Liver Transplantation Show Enrichment of Regulatory T Cells Before Proinflammatory Genes Are Downregulated

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12 December 2020

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

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12 December 2020

Tolerogenic Dendritic Cells for Regulatory T Cell Induction in Man

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12 December 2020

CD4 T cells from patients with acquired thrombotic thrombocytopenic purpura recognize CUB2 domain-derived peptides.

1 reference

12 December 2020

Profile of the Pleximmune blood test for transplant rejection risk prediction

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12 December 2020

Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation.

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12 December 2020

Clinical Use of Tolerogenic Dendritic Cells-Harmonization Approach in European Collaborative Effort

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12 December 2020

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

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12 December 2020

Prolonged intralymphatic delivery of dendritic cells through implantable lymphatic ports in patients with advanced cancer.

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12 December 2020

Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis

1 reference

12 December 2020

Age and gender leucocytes variances and references values generated using the standardized ONE-Study protocol

1 reference

12 December 2020

Cryopreserved vitamin D3-tolerogenic dendritic cells pulsed with autoantigens as a potential therapy for multiple sclerosis patients.

1 reference

12 December 2020

Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?

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12 December 2020

Engineering tolerance using biomaterials to target and control antigen presenting cells

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12 December 2020

Laser Ablation Inductively Coupled Plasma Mass Spectrometry: An Emerging Technology for Multiparametric Analysis of Tissue Antigens

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12 December 2020

Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies

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12 December 2020

Comparative Study of the Immunoregulatory Capacity of In Vitro Generated Tolerogenic Dendritic Cells, Suppressor Macrophages, and Myeloid-Derived Suppressor Cells

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12 December 2020

Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4 T cells partly via transforming growth factor-β1.

1 reference

12 December 2020

IL-10-Modulated Human Dendritic Cells for Clinical Use: Identification of a Stable and Migratory Subset with Improved Tolerogenic Activity

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12 December 2020

Advances in Molecular Imaging Strategies for In Vivo Tracking of Immune Cells

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12 December 2020

Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans

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12 December 2020

T cell receptor repertoires after adoptive transfer of expanded allogeneic regulatory T cells

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12 December 2020

Factors affecting long-term efficacy of T regulatory cell-based therapy in type 1 diabetes.

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12 December 2020

Prevention of Allograft Rejection by Use of Regulatory T Cells With an MHC-Specific Chimeric Antigen Receptor.

1 reference

12 December 2020

Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection.

1 reference

12 December 2020

Cell-Based Therapies with T Regulatory Cells

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12 December 2020

IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors

1 reference

12 December 2020

Liposome-based immunotherapy against autoimmune diseases: therapeutic effect on multiple sclerosis

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12 December 2020

Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants.

1 reference

12 December 2020

Differential transcriptome of tolerogenic versus inflammatory dendritic cells points to modulated T1D genetic risk and enriched immune regulation

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12 December 2020

Mild hypothermia provides Treg stability.

1 reference

12 December 2020

Dendritic Cells Transduced with Single Immunoglobulin IL-1-Related Receptor Exhibit Immature Properties and Prolong Islet Allograft Survival

1 reference

12 December 2020

High Throughput Automated Analysis of Big Flow Cytometry Data.

1 reference

12 December 2020

Monitoring T-Cell Responses in Translational Studies: Optimization of Dye-Based Proliferation Assay for Evaluation of Antigen-Specific Responses

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12 December 2020

Nanoparticle-Based Modulation and Monitoring of Antigen-Presenting Cells in Organ Transplantation

1 reference

12 December 2020

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

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12 December 2020

Shuttling Tolerogenic Dendritic Cells across the Blood-Brain Barrier In Vitro via the Introduction of De Novo C-C Chemokine Receptor 5 Expression Using Messenger RNA Electroporation.

1 reference

12 December 2020

Biomarkers of operational tolerance following kidney transplantation - The immune tolerance network studies of spontaneously tolerant kidney transplant recipients

1 reference

12 December 2020

Effects of ATX-MS-1467 immunotherapy over 16 weeks in relapsing multiple sclerosis.

1 reference

12 December 2020

Tolerogenic Dendritic Cells in Solid Organ Transplantation: Where Do We Stand?

1 reference

12 December 2020

CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells.

1 reference

12 December 2020

A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials.

1 reference

12 December 2020

A Phase I Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants.

1 reference

12 December 2020

Expanded autologous regulatory T-lymphocyte infusions in ALS: A phase I, first-in-human study.

1 reference

12 December 2020

TIGIT iTregs elicited by human regulatory macrophages control T cell immunity

1 reference

12 December 2020

Comparative transcriptomic profile of tolerogenic dendritic cells differentiated with vitamin D3, dexamethasone and rapamycin

1 reference

12 December 2020

Searching for the Transcriptomic Signature of Immune Tolerance Induction-Biomarkers of Safety and Functionality for Tolerogenic Dendritic Cells and Regulatory Macrophages

1 reference

12 December 2020

Identifiers

DOI

10.3389/FIMMU.2019.00181

1 reference

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28 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30853957 AND SRC:MED&resulttype=core&format=json

28 April 2020

PubMed publication ID

30853957

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