An improved synthesis of adefovir and related analogues (Q64100797)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30992729 AND SRC:MED&resulttype=core&format=json

3 May 2020

title

An improved synthesis of adefovir and related analogues (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30992729 AND SRC:MED&resulttype=core&format=json

3 May 2020

0 references

0 references

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30992729 AND SRC:MED&resulttype=core&format=json

3 May 2020

Timothy P O'Sullivan

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30992729 AND SRC:MED&resulttype=core&format=json

3 May 2020

author name string

Eileen M O'Leary

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30992729 AND SRC:MED&resulttype=core&format=json

3 May 2020

language of work or name

English

0 references

publication date

29 March 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30992729 AND SRC:MED&resulttype=core&format=json

Beilstein Journal of Organic Chemistry

3 May 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30992729 AND SRC:MED&resulttype=core&format=json

3 May 2020

volume

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30992729 AND SRC:MED&resulttype=core&format=json

3 May 2020

page(s)

801-810

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30992729 AND SRC:MED&resulttype=core&format=json

Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine

3 May 2020

cites work

1 reference

12 December 2020

Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro

1 reference

12 December 2020

Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines

1 reference

12 December 2020

A novel selective broad-spectrum anti-DNA virus agent

1 reference

12 December 2020

Anti-Retroviral and Pharmacological Properties of 9-(2-Phosphonylmethoxyethyl)Adenine (PMEA)

1 reference

12 December 2020

Synthesis and in vivo evaluation of prodrugs of 9-[2-(phosphonomethoxy)ethoxy]adenine

1 reference

12 December 2020

Amidines and guanidines in medicinal chemistry.

1 reference

12 December 2020

Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).

1 reference

12 December 2020

Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication.

1 reference

12 December 2020

Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine

1 reference

12 December 2020

Acyclic nucleotide analogs derived from 8-azapurines: synthesis and antiviral activity.

1 reference

12 December 2020

Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability

1 reference

12 December 2020

Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base

1 reference

12 December 2020

Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.

1 reference

12 December 2020

Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses

1 reference

12 December 2020

2-Amino-6-arylthio-9-[2-(phosphonomethoxy)ethyl]purine bis(2,2,2-trifluoroethyl) esters as novel HBV-specific antiviral reagents

1 reference

12 December 2020

Pharmacokinetic and antiretroviral activity in mice of oral [P(1),P(2)-bis[2-(adenin-9-yl)ethoxymethyl]phosphonate], a prodrug of 9-(2-phosphonylmethoxyethyl)adenine

1 reference

12 December 2020

Adefovir dipivoxil: a review of its use in chronic hepatitis B.

1 reference

12 December 2020

5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity

1 reference

12 December 2020

Design, synthesis, and characterization of a series of cytochrome P(450) 3A-activated prodrugs (HepDirect prodrugs) useful for targeting phosph(on)ate-based drugs to the liver

1 reference

12 December 2020

A novel class of phosphonate nucleosides. 9-[(1-phosphonomethoxycyclopropyl)methyl]guanine as a potent and selective anti-HBV agent

1 reference

12 December 2020

Adefovir dipivoxil in chronic hepatitis B infection

1 reference

12 December 2020

Acyclic nucleoside phosphonates: a key class of antiviral drugs

1 reference

12 December 2020

cycloSal-PMEA and cycloAmb-PMEA: potentially new phosphonate prodrugs based on the cycloSal-pronucleotide approach

1 reference

12 December 2020

Inhibition of hepatitis B virus (HBV) replication by pyrimidines bearing an acyclic moiety: effect on wild-type and mutant HBV.

1 reference

12 December 2020

Synthesis and antiviral evaluation of alkoxyalkyl esters of acyclic purine and pyrimidine nucleoside phosphonates against HIV-1 in vitro

1 reference

12 December 2020

Design and synthesis of novel bis(L-amino acid) ester prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) with improved anti-HBV activity

1 reference

12 December 2020

Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Novel α-Borano-Nucleotide Analogues of 9-[2-(Phosphonomethoxy)ethyl]adenine and (R)-9-[2-(Phosphonomethoxy)propyl]adenine

1 reference

12 December 2020

Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids

1 reference

12 December 2020

Some new acyclic nucleotide analogues as antiviral prodrugs: synthesis and bioactivities in vitro

1 reference

12 December 2020

Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors

1 reference

12 December 2020

Acyclic nucleoside bisphosphonates: synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines

1 reference

12 December 2020

Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines

1 reference

12 December 2020

New prodrugs of Adefovir and Cidofovir

1 reference

12 December 2020

Nephrotoxicity, including acquired Fanconi's syndrome, caused by adefovir dipivoxil - is there a safe dose?

1 reference

12 December 2020

2,3-Dicyclohexylsuccinimide as a directing/protecting group for the regioselective glycosylation or alkylation of purines

1 reference

12 December 2020

Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study

1 reference

12 December 2020

Dihydrolevoglucosenone (Cyrene) as a bio-based alternative for dipolar aprotic solvents

1 reference

12 December 2020

Synthesis of nucleoside phosphate and phosphonate prodrugs

1 reference

12 December 2020

Curious discoveries in antiviral drug development: the role of serendipity

1 reference

12 December 2020

Application of ionic liquid to polymorphic transformation of anti-viral/HIV drug adefovir dipivoxil

1 reference

12 December 2020

New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity

1 reference

12 December 2020

The ProTide Prodrug Technology: From the Concept to the Clinic

1 reference

12 December 2020

Identifiers

DOI

10.3762/BJOC.15.77

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30992729 AND SRC:MED&resulttype=core&format=json

3 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30992729 AND SRC:MED&resulttype=core&format=json

3 May 2020

PubMed publication ID

30992729

1 reference