Application of hepatic cytochrome b/P450 reductase null (HBRN) mice to study the role of cytochrome b in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine (Q64085104)

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scientific article published on 25 January 2019

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English	Application of hepatic cytochrome b/P450 reductase null (HBRN) mice to study the role of cytochrome b in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine	scientific article published on 25 January 2019

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20 April 2020

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine (English)

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20 April 2020

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20 April 2020

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20 April 2020

Marie Stiborová

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Marie Stiborova

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20 April 2020

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Lindsay Reed

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20 April 2020

Iveta Mrizova

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20 April 2020

Michaela Moserova

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20 April 2020

Heinz H Schmeiser

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20 April 2020

C Roland Wolf

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20 April 2020

Colin J Henderson

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20 April 2020

David H Phillips

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25 January 2019

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20 April 2020

Toxicology and Applied Pharmacology

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20 April 2020

366

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20 April 2020

64-74

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20 April 2020

Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of Cytochrome b5in the Oxidation of Testosterone and Nifedipine by Recombinant Cytochrome P450 3A4 and by Human Liver Microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat microsomes activating the anticancer drug ellipticine to species covalently binding to deoxyguanosine in DNA are a suitable model mimicking ellipticine bioactivation in humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA adduct formation by the anticancer drug ellipticine in rats determined by 32P postlabeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extending nature's leads: the anticancer agent ellipticine

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anticancer drug ellipticine forms covalent DNA adducts, mediated by human cytochromes P450, through metabolism to 13-hydroxyellipticine and ellipticine N2-oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of cytochrome P450 1A1 and its contribution to oxidation of a potential human carcinogen 1-phenylazo-2-naphthol (Sudan I) in human livers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidation of an antitumor drug ellipticine by peroxidases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian peroxidases activate anticancer drug ellipticine to intermediates forming deoxyguanosine adducts in DNA identical to those foundin vivo and generated from 12-hydroxyellipticine and 13-hydroxyellipticine

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidation pattern of the anticancer drug ellipticine by hepatic microsomes - similarity between human and rat systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation and persistence of DNA adducts of anticancer drug ellipticine in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anticancer drug ellipticine is a potent inducer of rat cytochromes P450 1A1 and 1A2, thereby modulating its own metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome b5 increases the rate of product formation by cytochrome P450 2B4 and competes with cytochrome P450 reductase for a binding site on cytochrome P450 2B4

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P450- and peroxidase-mediated oxidation of anticancer alkaloid ellipticine dictates its anti-tumor efficiency.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ellipticine and benzo(a)pyrene increase their own metabolic activation via modulation of expression and enzymatic activity of cytochromes P450 1A1 and 1A2

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome b5 shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O-acetyltransferases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ellipticine oxidation and DNA adduct formation in human hepatocytes is catalyzed by human cytochromes P450 and enhanced by cytochrome b5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the hepatic cytochrome P450 system

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ellipticines as DNA-targeted chemotherapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for cytochrome b5 in the In vivo disposition of anticancer and cytochrome P450 probe drugs in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of benzo[a]pyrene on metabolic activation of anticancer drug ellipticine in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of DNA adducts by ellipticine and its micellar form in rats - a comparative study

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN™) mice and pure enzymes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition of chromatin by the plant alkaloid, ellipticine as a dual binder.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of human DNA topoisomerase IIα by two novel ellipticine derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induced expression of microsomal cytochrome b 5 determined at mRNA and protein levels in rats exposed to ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome b5 plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53( / ), TP53( /-) and TP53(-/-) cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo-in vitro paradox

1 reference

https://pubmed.ncbi.nlm.nih.gov/30685480

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.TAAP.2019.01.020

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30685480 AND SRC:MED&resulttype=core&format=json

20 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30685480 AND SRC:MED&resulttype=core&format=json

20 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30685480 AND SRC:MED&resulttype=core&format=json

20 April 2020

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