MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer (Q64081418)

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English	MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer	No description defined

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scholarly article

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MCT-1/miR-34a/IL-6/IL-6R signaling axis promotes EMT progression, cancer stemness and M2 macrophage polarization in triple-negative breast cancer (English)

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triple-negative breast cancer

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author name string

Yueh-Shan Weng

1

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Hong-Yu Tseng

2

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Yen-An Chen

3

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Pei-Chun Shen

4

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Aushia Tanzih Al Haq

5

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Li-Mei Chen

6

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Yi-Chung Tung

7

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Hsin-Ling Hsu

8

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language of work or name

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publication date

18 March 2019

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Molecular Cancer

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18

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1

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42

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copyright license

Creative Commons Attribution 4.0 International

18 March 2019

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April 2022 Public Data File from Crossref

copyright status

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The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex

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https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

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Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

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MCT-1 oncogene downregulates p53 and destabilizes genome structure in the response to DNA double-strand damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct multiplexed measurement of gene expression with color-coded probe pairs

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https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

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Loss of p53 and MCT-1 overexpression synergistically promote chromosome instability and tumorigenicity

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https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

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Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

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Tumor-conditioned macrophages secrete migration-stimulating factor: a new marker for M2-polarization, influencing tumor cell motility

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https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling

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https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

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The antagonism between MCT-1 and p53 affects the tumorigenic outcomes

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https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant p53 Disrupts MCF-10A Cell Polarity in Three-dimensional Culture via Epithelial-to-mesenchymal Transitions

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via the NFkB pathway in advanced-stage epithelial ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

When monocyte life hangs by a thread

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 signaling pathway in targeted therapy for cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2 breast cancer by expanding the cancer stem cell population.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines driving breast cancer stemness

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Understanding and targeting cancer stem cells: therapeutic implications and challenges

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The two faces of IL-6 in the tumor microenvironment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNA-149 targets GIT1 to suppress integrin signaling and breast cancer metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MCT-1 expression and PTEN deficiency synergistically promote neoplastic multinucleation through the Src/p190B signaling activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor suppressor miR-34a targets PD-L1 and functions as a potential immunotherapeutic target in acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms that influence the macrophage m1-m2 polarization balance

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PDL1 Regulation by p53 via miR-34

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential therapeutic implications of IL-6/IL-6R/gp130-targeting agents in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A critical role of transcription factor YY1 in rheumatoid arthritis by regulation of interleukin-6.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liposomal Nanoparticles Carrying anti-IL6R Antibody to the Tumour Microenvironment Inhibit Metastasis in Two Molecular Subtypes of Breast Cancer Mouse Models

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenic MCT-1 activation promotes YY1-EGFR-MnSOD signaling and tumor progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor promoting role of anti-tumor macrophages in tumor microenvironment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunotherapeutic Interleukin-6 or Interleukin-6 receptor blockade in cancer: challenges and opportunities.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural and Functional Insights into Human Re-initiation Complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reprogramming of Tumor-Associated Macrophages with Anticancer Therapies: Radiotherapy versus Chemo- and Immunotherapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of Metastasis by NK Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin 6 induces M2 macrophage differentiation by STAT3 activation that correlates with gastric cancer progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MicroRNA: Dynamic Regulators of Macrophage Polarization and Plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammasomes and Cancer: The Dynamic Role of the Inflammasome in Tumor Development

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triple negative breast cancer: Key role of Tumor-Associated Macrophages in regulating the activity of anti-PD-1/PD-L1 agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting myeloid cells in the tumor sustaining microenvironment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6 trans-signalling mediates trabecular, but not cortical, bone loss after ovariectomy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunotherapeutic interventions of Triple Negative Breast Cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30885232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S12943-019-0988-0

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Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s12943-019-0988-0

PMC publication ID

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PubMed publication ID

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