Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis (Q64057135)

12 December 2020

A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells

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12 December 2020

A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection

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12 December 2020

Betaine effects on hepatic methionine metabolism elicited by short-term ethanol feeding

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12 December 2020

The synthesis rates of total liver protein and plasma albumin determined simultaneously in vivo in humans

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12 December 2020

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

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12 December 2020

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

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12 December 2020

Fatty acid cycling in human hepatoma cells and the effects of troglitazone

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12 December 2020

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

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12 December 2020

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

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12 December 2020

Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response

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12 December 2020

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

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12 December 2020

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

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12 December 2020

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

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12 December 2020

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

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12 December 2020

Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.

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12 December 2020

Hepatocyte transplantation into diseased mouse liver. Kinetics of parenchymal repopulation and identification of the proliferative capacity of tetraploid and octaploid hepatocytes

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12 December 2020

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

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12 December 2020

Ischemia-reperfusion injury of the liver with special reference to calcium-dependent mechanisms

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12 December 2020

Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway

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12 December 2020

ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

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12 December 2020

Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly

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12 December 2020

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

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12 December 2020

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

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12 December 2020

Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice

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12 December 2020

Synthesis of all plasma protein fractions except gamma globulins by the liver; the use of zone electrophoresis and lysine-epsilon-C14 to define the plasma proteins synthesized by the isolated perfused liver

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12 December 2020

ATF6 modulates SREBP2-mediated lipogenesis.

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12 December 2020

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

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12 December 2020

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

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12 December 2020

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

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12 December 2020

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

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12 December 2020

Role of CHOP in hepatic apoptosis in the murine model of intragastric ethanol feeding

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12 December 2020

Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis

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12 December 2020

Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response

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12 December 2020

Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation

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12 December 2020

Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

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12 December 2020

Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression

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12 December 2020

Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

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12 December 2020

Signal integration in the endoplasmic reticulum unfolded protein response

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12 December 2020

Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

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12 December 2020

Acyl chain-dependent effect of lysophosphatidylcholine on human neutrophils

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12 December 2020

Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes

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12 December 2020

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

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12 December 2020

Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease

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12 December 2020

The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes

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12 December 2020

Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice

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12 December 2020

Regulation of hepatic lipogenesis by the transcription factor XBP1

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12 December 2020

Membrane phospholipid synthesis and endoplasmic reticulum function

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12 December 2020

Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss

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12 December 2020

UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.

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12 December 2020

Activation of mammalian IRE1alpha upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins

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12 December 2020

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

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12 December 2020

IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

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12 December 2020

Pioglitazone reduces ER stress in the liver: direct monitoring of in vivo ER stress using ER stress-activated indicator transgenic mice.

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12 December 2020

A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice

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12 December 2020

Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death

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12 December 2020

Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis

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12 December 2020

CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis

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12 December 2020

Regulation of basal cellular physiology by the homeostatic unfolded protein response

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12 December 2020

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

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12 December 2020

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

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12 December 2020

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

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12 December 2020

Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice

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12 December 2020

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

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12 December 2020

ATF4 deficiency protects mice from high-carbohydrate-diet-induced liver steatosis

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12 December 2020

Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy

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12 December 2020

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

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12 December 2020

Death Receptor 5 Signaling Promotes Hepatocyte Lipoapoptosis

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12 December 2020

Mechanisms of lysophosphatidylcholine-induced hepatocyte lipoapoptosis

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12 December 2020

The unfolded protein response: from stress pathway to homeostatic regulation

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12 December 2020

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

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12 December 2020

Palmitoylated calnexin is a key component of the ribosome-translocon complex

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12 December 2020

Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance.

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12 December 2020

Extensive translatome remodeling during ER stress response in mammalian cells

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12 December 2020

The membrane stress response buffers lethal effects of lipid disequilibrium by reprogramming the protein homeostasis network

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12 December 2020

IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis

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12 December 2020

Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.

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12 December 2020

IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

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12 December 2020

Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy

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12 December 2020

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

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12 December 2020

ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading.

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12 December 2020

C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis

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12 December 2020

ATF4 protein deficiency protects against high fructose-induced hypertriglyceridemia in mice.

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12 December 2020

Liver Injury and the Activation of the Hepatic Myofibroblasts

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12 December 2020

Jnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis

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12 December 2020

Attenuation of steatohepatitis, fibrosis, and carcinogenesis in mice fed a methionine-choline deficient diet by CCAAT/enhancer-binding protein homologous protein deficiency.

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12 December 2020

The role of MAPK signalling pathways in the response to endoplasmic reticulum stress

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12 December 2020

Endoplasmic reticulum stress-induced hepatic stellate cell apoptosis through calcium-mediated JNK/P38 MAPK and Calpain/Caspase-12 pathways

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12 December 2020

A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB

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12 December 2020

ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development

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12 December 2020

Kupffer cells: increasingly significant role in nonalcoholic fatty liver disease

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12 December 2020

Mmu-miR-615-3p regulates lipoapoptosis by inhibiting C/EBP homologous protein

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12 December 2020

The RtcB RNA ligase is an essential component of the metazoan unfolded protein response

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12 December 2020

The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells

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12 December 2020

Lysophosphatidylcholine and lysophosphatidylinosiol--novel promissing signaling molecules and their possible therapeutic activity

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12 December 2020

METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.

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12 December 2020

ER stress induces NLRP3 inflammasome activation and hepatocyte death.

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12 December 2020

Endoplasmic reticulum stress of Kupffer cells involved in the conversion of natural regulatory T cells to Th17 cells in liver ischemia-reperfusion injury.

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12 December 2020

Endoplasmic Reticulum Stress in Hepatic Stellate Cells Promotes Liver Fibrosis via PERK-Mediated Degradation of HNRNPA1 and Up-regulation of SMAD2.

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12 December 2020

Hepatocyte X-box binding protein 1 deficiency increases liver injury in mice fed a high-fat/sugar diet

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12 December 2020

Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner

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12 December 2020

The effect of oleic and palmitic acid on induction of steatosis and cytotoxicity on rat hepatocytes in primary culture

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12 December 2020

Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone Calnexin

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12 December 2020

Unfolded protein response induced by Brefeldin A increases collagen type I levels in hepatic stellate cells through an IRE1α, p38 MAPK and Smad-dependent pathway.

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12 December 2020

Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing.

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12 December 2020

C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis.

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12 December 2020

XBP1s Is an Anti-lipogenic Protein

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12 December 2020

Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis

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12 December 2020

Quercetin stimulates mitochondrial apoptosis dependent on activation of endoplasmic reticulum stress in hepatic stellate cells

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12 December 2020

Etoposide Induces Apoptosis in Activated Human Hepatic Stellate Cells via ER Stress

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12 December 2020

Structural Insights into IRE1 Functions in the Unfolded Protein Response

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12 December 2020

ER Stress-induced Inflammasome Activation Contributes to Hepatic Inflammation and Steatosis

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12 December 2020

The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy

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12 December 2020

Inhibition of sphingosine 1-phosphate signaling ameliorates murine nonalcoholic steatohepatitis

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12 December 2020

The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice

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12 December 2020

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.

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12 December 2020

Role of Protein Quality Control Failure in Alcoholic Hepatitis Pathogenesis

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12 December 2020

4μ8C Inhibits Insulin Secretion Independent of IRE1α RNase Activity

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12 December 2020

The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity

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12 December 2020

Azithromycin attenuates myofibroblast differentiation and lung fibrosis development through proteasomal degradation of NOX4.

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12 December 2020

Azithromycin for idiopathic acute exacerbation of idiopathic pulmonary fibrosis: a retrospective single-center study

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12 December 2020

Physiological/pathological ramifications of transcription factors in the unfolded protein response

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12 December 2020

Autophagy mediated by endoplasmic reticulum stress enhances the caffeine-induced apoptosis of hepatic stellate cells

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12 December 2020

An unfolded protein-induced conformational switch activates mammalian IRE1.

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12 December 2020

Recent insights into PERK-dependent signaling from the stressed endoplasmic reticulum

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12 December 2020

Current and Future Therapeutic Regimens for Non-alcoholic Fatty Liver Disease (NAFLD) and Non-alcoholic Steatohepatitis (NASH).

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12 December 2020

In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress

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12 December 2020

The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerization

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12 December 2020

Bax Inhibitor-1 protects from Non-Alcoholic Steatohepatitis by limiting IRE1α signaling

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12 December 2020

Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation.

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12 December 2020

Toxoplasma gondii dense granule protein 15 induces apoptosis in choriocarcinoma JEG-3 cells through endoplasmic reticulum stress.

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12 December 2020

IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs.

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12 December 2020

Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis

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12 December 2020

IRE1α aggravates ischemia reperfusion injury of fatty liver by regulating phenotypic transformation of kupffer cells

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12 December 2020

Alcoholic liver disease

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12 December 2020

Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate

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12 December 2020

Lipid bilayer stress-activated IRE-1 modulates autophagy during endoplasmic reticulum stress

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12 December 2020