Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children (Q63433311)

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scientific article published on 30 January 2019

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English	Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children	scientific article published on 30 January 2019

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29 April 2020

Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children (English)

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Francisco Madrid-Gambin

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Tuulia Hyötyläinen

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Sophie Sabherwal

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Melanie Föcking

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Tommi Suvitaival

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Linda Ahonen

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Ismo Mattila

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Caitriona Scaife

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Sean Madden

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Lorraine Brennan

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Jane A English

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29 April 2020

Biological Psychiatry

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29 April 2020

Genetic epidemiology of low-density lipoprotein subclass phenotypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

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inferred from PubMed ID database lookup

The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysophosphatidylcholine molecular species in low density lipoprotein of type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Children's Self-Reported Psychotic Symptoms and Adult Schizophreniform Disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysophosphatidylcholine inhibits the expression of prostacyclin stimulating factor in cultured vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced erythrocyte membrane essential fatty acids and increased lipid peroxides in schizophrenia at the never-medicated first-episode of psychosis and after years of treatment with antipsychotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulating oxidized low-density lipoprotein (LDL) is associated with risk factors of the metabolic syndrome and LDL size in clinically healthy 58-year-old men (AIR study).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methods for reliability and uncertainty assessment and for applicability evaluations of classification- and regression-based QSARs

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emotional and behavioural antecedents of young adults who screen positive for non-affective psychosis: a 21-year birth cohort study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered interactions of tryptophan metabolites in first-episode neuroleptic-naive patients with schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global proteomic profiling reveals altered proteomic signature in schizophrenia serum

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adducts

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early detection of psychosis: positive effects on 5-year outcome

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolome in schizophrenia and other psychotic disorders: a general population-based study

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-NMDA receptor encephalitis: an important differential diagnosis in psychosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential metabolite markers of schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidized phospholipids are present on plasminogen, affect fibrinolysis, and increase following acute myocardial infarction

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinicopathological significance of psychotic experiences in non-psychotic young people: evidence from four population-based studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

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Cohort Profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

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Cohort profile: the 'children of the 90s'—the index offspring of the Avon Longitudinal Study of Parents and Children

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolomic analysis of biochemical changes in the plasma and urine of first-episode neuroleptic-naïve schizophrenia patients after treatment with risperidone

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An updated and conservative systematic review and meta-analysis of epidemiological evidence on psychotic experiences in children and adults: on the pathway from proneness to persistence to dimensional expression across mental disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel biomarkers for pre-diabetes identified by metabolomics

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Childhood obesity is associated with changes in the serum metabolite profile

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Visualising associations between paired 'omics' data sets

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Psychotic experiences and psychotic disorders at age 18 in relation to psychotic experiences at age 12 in a longitudinal population-based cohort study

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipidomics reveals early metabolic changes in subjects with schizophrenia: effects of atypical antipsychotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Knowledge discovery by accuracy maximization.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between the lipidome, inflammatory markers and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: a population-based longitudinal study

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid growth and childhood obesity are strongly associated with lysoPC(14:0).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Omega-3 fatty acids in first-episode schizophrenia - a randomized controlled study of efficacy and relapse prevention (OFFER): rationale, design, and methods

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Erythrocyte polyunsaturated fatty acid levels in young people at ultra-high risk for psychotic disorder and healthy adolescent controls

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Global metabolomic profiling targeting childhood obesity in the Hispanic population

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced protein synthesis in schizophrenia patient-derived olfactory cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipidomics Reveals Associations of Phospholipids With Obesity and Insulin Resistance in Young Adults.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysfunction in the coagulation system and schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Schizophrenia risk from complex variation of complement component 4

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The bidirectional associations between psychotic experiences and DSM-IV mental disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic Characterization of a Rare Genetic Variation Within APOC3 and Its Lipoprotein Lipase-Independent Effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Persistence or recurrence of non-psychotic comorbid mental disorders associated with 6-year poor functional outcomes in patients at ultra high risk for psychosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipids in psychiatric disorders and preventive medicine

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Individualized Risk Calculator for Research in Prodromal Psychosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma lipidomics reveals potential lipid markers of major depressive disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic evidence for a role of the SREBP transcription system and lipid biosynthesis in schizophrenia and antipsychotic treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of transition from ultra-high risk to first-episode psychosis using a probabilistic model combining history, clinical assessment and fatty-acid biomarkers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

KODAMA: an R package for knowledge discovery and data mining

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early Programming of Obesity Throughout the Life Course: A Metabolomics Perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cord Blood Metabolome Is Highly Associated with Birth Weight, but Less Predictive for Later Weight Development

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

First-Episode Schizophrenia and Diabetes Risk

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased cardiovascular mortality in people with schizophrenia: a 24-year national register study

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urinary Metabolic Phenotyping of Women with Lower Urinary Tract Symptoms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A systematic review of metabolite biomarkers of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case-Control Study of the ALSPAC Longitudinal Birth Cohort.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mixOmics: An R package for 'omics feature selection and multiple data integration

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum metabolites and risk of myocardial infarction and ischemic stroke: a targeted metabolomic approach in two German prospective cohorts

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Schizophrenia-risk and urban birth are associated with proteomic changes in neonatal dried blood spots

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Update on the laboratory investigation of dyslipidemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysglycaemia, Inflammation and Psychosis: Findings From the UK ALSPAC Birth Cohort.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Networks of blood proteins in the neuroimmunology of schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/30878195

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes

1 reference

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1 reference

Europe PubMed Central

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29 April 2020

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