mTOR: A Cellular Regulator Interface in Health and Disease (Q61807513)

12 December 2020

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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12 December 2020

Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells

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12 December 2020

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

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12 December 2020

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

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12 December 2020

Rapamycin inhibits human adipocyte differentiation in primary culture

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12 December 2020

Surfing the p53 network

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12 December 2020

Quick guide: target of rapamycin

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12 December 2020

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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12 December 2020

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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12 December 2020

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

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12 December 2020

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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12 December 2020

The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin

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12 December 2020

Tuberous sclerosis: from tubers to mTOR.

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12 December 2020

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

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12 December 2020

Rapamycin attenuates load-induced cardiac hypertrophy in mice

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12 December 2020

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

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12 December 2020

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

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12 December 2020

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

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12 December 2020

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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12 December 2020

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

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12 December 2020

On the Origin of Cancer Cells

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12 December 2020

A 34 bp deletion within TSC2 is a rare polymorphism, not a pathogenic mutation.

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12 December 2020

TSC2 mediates cellular energy response to control cell growth and survival

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12 December 2020

Genetics: influence of TOR kinase on lifespan in C. elegans

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12 December 2020

Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

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12 December 2020

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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12 December 2020

The LKB1 tumor suppressor negatively regulates mTOR signaling

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12 December 2020

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

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12 December 2020

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

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12 December 2020

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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12 December 2020

Autophagy in health and disease: a double-edged sword

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12 December 2020

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

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12 December 2020

Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

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12 December 2020

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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12 December 2020

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

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12 December 2020

Rheb binds and regulates the mTOR kinase

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12 December 2020

The coordinate regulation of the p53 and mTOR pathways in cells

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12 December 2020

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

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12 December 2020

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

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12 December 2020

Extension of chronological life span in yeast by decreased TOR pathway signaling

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12 December 2020

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

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12 December 2020

The TOR signalling network from yeast to man.

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12 December 2020

The amino acid sensitive TOR pathway from yeast to mammals.

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12 December 2020

Current development of mTOR inhibitors as anticancer agents

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12 December 2020

Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

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12 December 2020

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

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12 December 2020

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

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12 December 2020

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

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12 December 2020

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

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12 December 2020

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

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12 December 2020

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

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12 December 2020

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

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12 December 2020

The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man

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12 December 2020

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

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12 December 2020

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

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12 December 2020

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

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12 December 2020

PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

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12 December 2020

PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

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12 December 2020

mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor

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12 December 2020

AMPK phosphorylation of raptor mediates a metabolic checkpoint

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12 December 2020

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

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12 December 2020

Regulation of TORC1 by Rag GTPases in nutrient response

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12 December 2020

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

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12 December 2020

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

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12 December 2020

Nutrient signals driving cell growth.

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12 December 2020

Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma.

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12 December 2020

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

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12 December 2020

Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice

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12 December 2020

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

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12 December 2020

Rapamycin and mTOR kinase inhibitors

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12 December 2020

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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12 December 2020

Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1

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12 December 2020

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

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12 December 2020

Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6.

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12 December 2020

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

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12 December 2020

Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster

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12 December 2020

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

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12 December 2020

Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue

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12 December 2020

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

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12 December 2020

Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly

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12 December 2020

Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway

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12 December 2020

Structure of the human mTOR complex I and its implications for rapamycin inhibition.

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12 December 2020

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

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12 December 2020

How a lipid mediates tumour suppression. Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden

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12 December 2020

Pushing the envelope in the mTOR pathway: the second generation of inhibitors

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12 December 2020

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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12 December 2020

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

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12 December 2020

Inhibition of human in-stent restenosis: a molecular view

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12 December 2020

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

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12 December 2020

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

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12 December 2020

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway

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12 December 2020

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

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12 December 2020

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

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12 December 2020

Rapamycin passes the torch: a new generation of mTOR inhibitors

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12 December 2020

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H( )-ATPase

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12 December 2020

mTOR inhibitors in cancer therapy.

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12 December 2020

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

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12 December 2020

The translational landscape of mTOR signalling steers cancer initiation and metastasis

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12 December 2020

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

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12 December 2020

mTOR signaling in growth control and disease

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12 December 2020

A unifying model for mTORC1-mediated regulation of mRNA translation.

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12 December 2020

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO

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12 December 2020

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.

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12 December 2020

PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12

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12 December 2020

Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression

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12 December 2020

The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis

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12 December 2020

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

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12 December 2020

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1

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12 December 2020

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

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12 December 2020

mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.

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12 December 2020

Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy

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12 December 2020

Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer

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12 December 2020

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.

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12 December 2020

Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis

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12 December 2020

Duration of rapamycin treatment has differential effects on metabolism in mice

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12 December 2020

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.

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12 December 2020

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

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12 December 2020

mTOR kinase structure, mechanism and regulation

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12 December 2020

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

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12 December 2020

Incidence and risk of treatment-related mortality with mTOR inhibitors everolimus and temsirolimus in cancer patients: a meta-analysis

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12 December 2020

Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression

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12 December 2020

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

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12 December 2020

Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases

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12 December 2020

The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

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12 December 2020

SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1α-dependent glycolysis

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12 December 2020

mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity

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12 December 2020

Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells

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12 December 2020

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

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12 December 2020

Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth.

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12 December 2020

ATG13: just a companion, or an executor of the autophagic program?

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12 December 2020

Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle.

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12 December 2020

Coordinated regulation of protein synthesis and degradation by mTORC1

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12 December 2020

The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1

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12 December 2020

The structural basis for mTOR function

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12 December 2020

Autophagy and its effects: making sense of double-edged swords

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12 December 2020

Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

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12 December 2020

Sestrins inhibit mTORC1 kinase activation through the GATOR complex

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12 December 2020

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

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12 December 2020

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

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12 December 2020

Metabolism. Differential regulation of mTORC1 by leucine and glutamine

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12 December 2020

Autophagy and neurodegeneration

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12 December 2020

mLST8 Promotes mTOR-Mediated Tumor Progression

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12 December 2020

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging

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12 December 2020

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

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12 December 2020

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.

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12 December 2020

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation

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12 December 2020

Drosophila Longevity Assurance Conferred by Reduced Insulin Receptor Substrate Chico Partially Requires d4eBP.

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12 December 2020

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

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12 December 2020

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12 December 2020

Sestrin2 is a leucine sensor for the mTORC1 pathway

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12 December 2020

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

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12 December 2020

The Akt-mTOR axis is a pivotal regulator of eccentric hypertrophy during volume overload

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12 December 2020

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.

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12 December 2020

Potential therapeutic effects of mTOR inhibition in atherosclerosis.

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12 December 2020

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

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12 December 2020

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

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12 December 2020

Architecture of human mTOR complex 1

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12 December 2020

ATP-site binding inhibitor effectively targets mTORC1 and mTORC2 complexes in glioblastoma

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12 December 2020

Rag GTPase in amino acid signaling

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12 December 2020

Control of proteasomal proteolysis by mTOR

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12 December 2020

Zhang & Manning reply

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12 December 2020

Lysosomal recruitment of TSC2 is a universal response to cellular stress

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12 December 2020

The multifaceted role of autophagy in tumor evasion from immune surveillance

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12 December 2020

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

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12 December 2020

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

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12 December 2020

mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer

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12 December 2020

Tor forms a dimer through an N-terminal helical solenoid with a complex topology.

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12 December 2020

mTOR Inhibitors at a Glance

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12 December 2020

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

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12 December 2020

An evolutionarily conserved pathway controls proteasome homeostasis

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12 December 2020

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

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12 December 2020

Recent Advances in Mammalian Target of Rapamycin Inhibitor Use in Heart and Lung Transplantation

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12 December 2020

F-actin rearrangement is regulated by mTORC2/Akt/Girdin in mouse fertilized eggs.

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12 December 2020

Commentary: Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

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12 December 2020

Alleviating VLDL overproduction is an important mechanism for Laminaria japonica polysaccharide to inhibit atherosclerosis in LDLr-/- mice with diet-induced insulin resistance

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12 December 2020

Nutrient sensing and TOR signaling in yeast and mammals

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12 December 2020

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

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12 December 2020

SZT2 dictates GATOR control of mTORC1 signalling.

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12 December 2020

mTOR Inhibition and Cardiovascular Diseases: Dyslipidemia and Atherosclerosis

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12 December 2020

Tor1 and CK2 kinases control a switch between alternative ribosome biogenesis pathways in a growth-dependent manner

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12 December 2020

A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.

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12 December 2020

mTOR Signaling in Growth, Metabolism, and Disease.

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12 December 2020

Therapeutic implication of autophagy in neurodegenerative diseases.

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12 December 2020

The small GTPases Ras and Rheb studied by multidimensional NMR spectroscopy: structure and function

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12 December 2020

"mTOR Signaling Pathway": A Potential Target of Curcumin in the Treatment of Spinal Cord Injury.

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12 December 2020

Inhibiting 4EBP1 in glioblastoma.

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12 December 2020

Differential control of ageing and lifespan by isoforms and splice variants across the mTOR network.

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12 December 2020

Loss of foxo rescues stem cell aging in Drosophila germ line.

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12 December 2020

FLCN: The causative gene for Birt-Hogg-Dubé syndrome

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12 December 2020

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.

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12 December 2020

The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling

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12 December 2020

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.

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12 December 2020

RNA polymerase III limits longevity downstream of TORC1.

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12 December 2020

Regulation of the Tumor-Suppressor BECLIN 1 by Distinct Ubiquitination Cascades

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12 December 2020

mTORC2 Promotes Tumorigenesis via Lipid Synthesis

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12 December 2020

Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance.

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12 December 2020

Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR.

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12 December 2020

mTOR Cross-Talk in Cancer and Potential for Combination Therapy.

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12 December 2020

Autophagy and Longevity

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12 December 2020

A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.

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12 December 2020

New Insights Into the Role of mTOR Signaling in the Cardiovascular System.

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12 December 2020

Architecture of the human mTORC2 core complex.

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12 December 2020

Branching the Tel2 pathway for exact fit on phosphatidylinositol 3-kinase-related kinases.

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12 December 2020

Autophagy stimulation as a promising approach in treatment of neurodegenerative diseases

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12 December 2020

Cryo-EM structure of human mTOR complex 2.

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12 December 2020

Architecture and activation of phosphatidylinositol 3-kinase related kinases

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12 December 2020

Inhibition of FOXO1 transcription factor in primary human adipocytes mimics the insulin-resistant state of type 2 diabetes

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12 December 2020

The TORC1-Sch9 pathway as a crucial mediator of chronological lifespan in the yeast Saccharomyces cerevisiae

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12 December 2020

A component of the TOR (Target Of Rapamycin) nutrient-sensing pathway plays a role in circadian rhythmicity in Neurospora crassa

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12 December 2020

Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration?

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12 December 2020

Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives

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12 December 2020