Formation of DNA adducts of the food-derived mutagen 2-amino-9H-pyrido-[2,3-b]indole (A(α)C) and bioassay of mammary gland carcinogenicity in Sprague–Dawley rats (Q61696723)

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scientific article published on 01 December 1998

Language	Label	Description	Also known as
English	Formation of DNA adducts of the food-derived mutagen 2-amino-9H-pyrido-[2,3-b]indole (A(α)C) and bioassay of mammary gland carcinogenicity in Sprague–Dawley rats	scientific article published on 01 December 1998

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9862644 AND SRC:MED&resulttype=core&format=json

7 December 2019

Formation of DNA adducts of the food-derived mutagen 2-amino-9H-pyrido-[2,3-b]indole (A(alpha)C) and bioassay of mammary gland carcinogenicity in Sprague-Dawley rats (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9862644 AND SRC:MED&resulttype=core&format=json

7 December 2019

Roberta S. King

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9862644 AND SRC:MED&resulttype=core&format=json

7 December 2019

author name string

N Sadrieh

2

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7 December 2019

E G Snyderwine

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9862644 AND SRC:MED&resulttype=core&format=json

7 December 2019

H A Schut

4

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7 December 2019

publication date

1 December 1998

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7 December 2019

Food and Chemical Toxicology

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9862644 AND SRC:MED&resulttype=core&format=json

7 December 2019

36

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7 December 2019

12

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9862644 AND SRC:MED&resulttype=core&format=json

7 December 2019

1033-1041

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9862644 AND SRC:MED&resulttype=core&format=json

7 December 2019

Diet and Breast Cancer

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Dietary fats and cancer

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In vivo mutagenicity and DNA adduct levels of heterocyclic amines in Muta mice and c-myc/lacZ double transgenic mice

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Mutagenic activation of IQ, PhIP and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo

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Possible mechanisms for PhIP-DNA adduct formation in the mammary gland of female Sprague-Dawley rats

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Induction of mammary tumors in female Sprague-Dawley rats by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and effect of dietary fat

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DNA adducts, mutations and cancer

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Rapid induction of mammary carcinoma in the rat and the influence of hormones on the tumors

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A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

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Induction of tumors in the Zymbal gland, oral cavity, colon, skin and mammary gland of F344 rats by a mutagenic compound, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline

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Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research

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7 January 2021

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Identification of N-(Deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine as the major adduct formed by the food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, with DNA

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Simultaneous determination of amino-alpha-carbolines and amino-gamma-carbolines in cigarette smoke condensate by high-performance liquid chromatography

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Determination of mutagens, amino-alpha-carbolines in grilled foods and cigarette smoke condensate

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7 January 2021

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Metabolic activation of 2-amino-9H-pyrido[2,3-b]indole by rat-liver microsomes

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Carcinogenicity in mice of mutagenic compounds from glutamic acid and soybean globulin pyrolysates

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7 January 2021

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Carcinogenicities of heterocyclic amines in cooked food

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7 January 2021

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Characterization of the major DNA adduct formed by the food mutagen 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAalphaC) in primary rat hepatocytes.

1 reference

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7 January 2021

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Identification of the major hepatic DNA adduct formed by the food mutagen 2-amino-9H-pyrido[2,3-b]indole (A alpha C).

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7 January 2021

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32P-postlabeling analysis of DNA adducts persisting for up to 42 weeks in the skin, epidermis and dermis of mice treated topically with 7,12-dimethylbenz[a]anthracene.

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7 January 2021

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Heterocyclic amines: occurrence and prevention in cooked food

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7 January 2021

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Formation of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in male Fischer-344 rats

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Accumulation of DNA adducts of 2-amino-3-methylimidazo[4,5-f] quinoline (IQ) in tissues and white blood cells of the Fischer-344 rat after multiple oral dosing.

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Some perspectives on the nutritional aspects of breast cancer research. Food-derived heterocyclic amines as etiologic agents in human mammary cancer

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32P-postlabeling analysis of IQ, MeIQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MeIQx- and PhIP-treated monkeys.

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Proliferation, development and DNA adduct levels in the mammary gland of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a high fat diet.

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Mammary gland carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Sprague-Dawley rats on high- and low-fat diets.

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Use of the 32P-postlabeling method to detect DNA adducts of 2-amino-3-methylimidazolo[4,5-f]quinoline (IQ) in monkeys fed IQ: identification of the N-(deoxyguanosin-8-yl)-IQ adduct.

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Identification of N-(deoxyguanosin-8-yl)-2-amino-3,4-dimethylimidazo[4,5-f]quinoline (dG-C8-MeIQ) as a major adduct formed by MeIQ with nucleotides in vitro with DNA in vivo.

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Characterization of DNA adducts formed in vitro by reaction of N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline at the C-8 and N2 atoms of guanine.

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Identifiers

10.1016/S0278-6915(98)00088-X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9862644 AND SRC:MED&resulttype=core&format=json

7 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9862644 AND SRC:MED&resulttype=core&format=json

7 December 2019

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