HIV-1 Nef protects human-monocyte-derived macrophages from HIV-1-induced apoptosis (Q61319055)

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16 January 2020

title

HIV-1 Nef protects human-monocyte-derived macrophages from HIV-1-induced apoptosis (English)

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16 January 2020

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1

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Maurizio Federico

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16445909 AND SRC:MED&resulttype=core&format=json

16 January 2020

Massimo Federico

3

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author name string

Eleonora Olivetta

1

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Maurizio Federico

2

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language of work or name

English

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publication date

27 January 2006

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16445909 AND SRC:MED&resulttype=core&format=json

Experimental Cell Research

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published in

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volume

312

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issue

6

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page(s)

890-900

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Functions of the HIV-1 Nef protein

16 January 2020

cites work

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Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4 T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans

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Evidence for human immunodeficiency virus type 1 replication in vivo in CD14( ) monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy

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Monocytes harbour replication-competent, non-latent HIV-1 in patients on highly active antiretroviral therapy.

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HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages

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HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection

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T-tropic human immunodeficiency virus (HIV) type 1 Nef protein enters human monocyte-macrophages and induces resistance to HIV replication: a possible mechanism of HIV T-tropic emergence in AIDS.

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HIV-1 Nef induces the release of inflammatory factors from human monocyte/macrophages: involvement of Nef endocytotic signals and NF-kappa B activation

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Apoptosis of uninfected cells induced by HIV envelope glycoproteins

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HIV Type 1 Tat Protein Induces Apoptosis and Death in Jurkat Cells

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HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim.

7 January 2021

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Lentiviral delivery of HIV-1 Vpr protein induces apoptosis in transformed cells

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Human immunodeficiency virus type 1 Vpr induces apoptosis in human neuronal cells

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Evidence for a cytopathogenicity determinant in HIV-1 Vpr.

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The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB-dependent expression of antiapoptotic factors

7 January 2021

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HIV‐1 Nef protein‐induced apoptotic cytolysis of a broad spectrum of uninfected human blood cells independently of CD95(Fas)

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Human Immunodeficiency virus type 1 Nef potently induces apoptosis in primary human brain microvascular endothelial cells via the activation of caspases

7 January 2021

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Extracellular Nef protein targets CD4 T cells for apoptosis by interacting with CXCR4 surface receptors

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HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

7 January 2021

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HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals

7 January 2021

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Apoptosis enhancement by the HIV-1 Nef protein.

7 January 2021

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HIV-1 Nef promotes survival of TF-1 macrophages by inducing Bcl-XL expression in an extracellular signal-regulated kinase-dependent manner

7 January 2021

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Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

7 January 2021

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inferred from DOI database lookup

7 January 2021

based on heuristic

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

1 reference

https://api.crossref.org/works/10.1016/J.YEXCR.2005.12.003

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef viruses but not for down-regulation of CD4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.YEXCR.2005.12.003

Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes

7 January 2021

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https://api.crossref.org/works/10.1016/J.YEXCR.2005.12.003

Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.YEXCR.2005.12.003

Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.YEXCR.2005.12.003

PKC epsilon is involved in JNK activation that mediates LPS-induced TNF-alpha, which induces apoptosis in macrophages

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.YEXCR.2005.12.003

HIV-1 expression protects macrophages and microglia from apoptotic death.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.YEXCR.2005.12.003

Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.YEXCR.2005.12.003

Human immunodeficiency virus 1 favors the persistence of infection by activating macrophages through TNF.

7 January 2021

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10.1016/J.YEXCR.2005.12.003

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16445909 AND SRC:MED&resulttype=core&format=json

16 January 2020

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