Blockade of LAG-3 Immune Checkpoint Combined With Therapeutic Vaccination Restore the Function of Tissue-Resident Anti-viral CD8 T Cells and Protect Against Recurrent Ocular Herpes Simplex Infection and Disease (Q60951075)

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English	Blockade of LAG-3 Immune Checkpoint Combined With Therapeutic Vaccination Restore the Function of Tissue-Resident Anti-viral CD8 T Cells and Protect Against Recurrent Ocular Herpes Simplex Infection and Disease	No description defined

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scholarly article

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Blockade of LAG-3 Immune Checkpoint Combined With Therapeutic Vaccination Restore the Function of Tissue-Resident Anti-viral CD8 T Cells and Protect Against Recurrent Ocular Herpes Simplex Infection and Disease (English)

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author name string

Soumyabrata Roy

1

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Pierre-Grégoire Coulon

2

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Ruchi Srivastava

3

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Hawa Vahed

4

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Grace J Kim

5

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Sager S Walia

6

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Taikun Yamada

7

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Mona A Fouladi

8

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Vincent T Ly

9

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Lbachir BenMohamed

10

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language of work or name

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publication date

2018

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Frontiers in Immunology

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9

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2922

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copyright license

Creative Commons Attribution 4.0 International

17 December 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

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Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of diverse primary herpes simplex virus type 1 gB-specific cytotoxic T-cell response showing a preferential V beta bias

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD4/major histocompatibility complex class II interaction analyzed with CD4‐ and lymphocyte activation gene‐3 (LAG‐3)‐Ig fusion proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epitope Specificity of H-2Kb-Restricted, HSV-1-, and HSV-2-Cross-Reactive Cytotoxic T Lymphocyte Clones

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymphocyte-activation gene 3/major histocompatibility complex class II interaction modulates the antigenic response of CD4 T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cell major histocompatibility complex class II molecules down-regulate CD4 T cell clone responses following LAG-3 binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the major histocompatibility complex class II binding site on LAG-3 protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Superantigen activation of CD4 and CD8 T cells from HIV-infected subjects: role of costimulatory molecules and antigen-presenting cells (APC)

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunization with a single major histocompatibility complex class I-restricted cytotoxic T-lymphocyte recognition epitope of herpes simplex virus type 2 confers protective immunity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Establishment of latent herpes simplex virus type 1 infection in resistant, sensitive, and immunodeficient mouse strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The immune response to ocular herpes simplex virus type 1 infection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence of HSV-1 LAT in human trigeminal, geniculate, and vestibular ganglia and its implication for cranial nerve syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel herpes simplex virus type 1 transcript (AL-RNA) antisense to the 5' end of the latency-associated transcript produces a protein in infected rabbits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Latent herpesvirus infection in human trigeminal ganglia causes chronic immune response

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Herpes simplex virus virion host shutoff protein: immune evasion mediated by a viral RNase?

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that spontaneous reactivation of herpes virus does not occur in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restoring function in exhausted CD8 T cells during chronic viral infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diversity of the CD8 T-cell response to herpes simplex virus type 2 proteins among persons with genital herpes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective retention of herpes simplex virus-specific T cells in latently infected human trigeminal ganglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rates of reactivation of latent herpes simplex virus from mouse trigeminal ganglia ex vivo correlate directly with viral load and inversely with number of infiltrating CD8 T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal ganglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular signature of CD8 T cell exhaustion during chronic viral infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HLA-A*0201-restricted CD8 cytotoxic T lymphocyte epitopes identified from herpes simplex virus glycoprotein D.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stern-gerlach study of multidecker lanthanide-cyclooctatetraene sandwich clusters

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymptomatic human CD4 cytotoxic T-cell epitopes identified from herpes simplex virus glycoprotein B

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noncytotoxic lytic granule-mediated CD8 T cell inhibition of HSV-1 reactivation from neuronal latency

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coregulation of CD8 T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Level of herpes simplex virus type 1 latency correlates with severity of corneal scarring and exhaustion of CD8 T cells in trigeminal ganglia of latently infected mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of a glycoprotein K (gK) CD8 T-cell epitope of herpes simplex virus on virus replication and pathogenicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High antigen levels are the cause of T cell exhaustion during chronic viral infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New concepts in herpes simplex virus vaccine development: notes from the battlefield

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron-interacting satellite glial cells in human trigeminal ganglia have an APC phenotype.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presence of lytic HSV-1 transcripts and clonally expanded T cells with a memory effector phenotype in human sensory ganglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms employed by herpes simplex virus 1 to inhibit the interferon response

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early CD4( ) T cell help prevents partial CD8( ) T cell exhaustion and promotes maintenance of Herpes Simplex Virus 1 latency

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developing an asymptomatic mucosal herpes vaccine: the present and the future

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel HLA (HLA-A*0201) transgenic rabbit model for preclinical evaluation of human CD8 T cell epitope-based vaccines against ocular herpes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunization with Different Viral Antigens Alters the Pattern of T Cell Exhaustion and Latency in Herpes Simplex Virus Type 1-Infected Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of LAT in increased CD8 T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Future Viral Vectors For the Delivery of Asymptomatic Herpes Epitope-based Immunotherapeutic Vaccines

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Herpes Simplex Virus 1 Latency-Associated Transcript Promotes Functional Exhaustion of Virus-Specific CD8 T Cells in Latently Infected Trigeminal Ganglia: a Novel Immune Evasion Mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cell exhaustion

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD11c Controls Herpes Simplex Virus 1 Responses To Limit Virus Replication during Primary Infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of Herpes Simplex Virus 1-Encoded MicroRNAs in Human Trigeminal Ganglia and Their Relation to Local T-Cell Infiltrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of HSV-1 latency in human trigeminal ganglia—current overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD8 T cells patrol HSV-1-infected trigeminal ganglia and prevent viral reactivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunodominant “Asymptomatic” Herpes Simplex Virus 1 and 2 Protein Antigens Identified by Probing Whole-ORFome Microarrays with Serum Antibodies from Seropositive Asymptomatic versus Symptomatic Individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of Potential Diagnostic and Vaccine Antigens in Herpes Simplex Virus 1 and 2 by Proteome-Wide Antibody Profiling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The herpes simplex virus type 1 latency-associated transcript inhibits phenotypic and functional maturation of dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Future of an "Asymptomatic" T-cell Epitope-Based Therapeutic Herpes Simplex Vaccine

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PD-L1/B7-H1 regulates the survival but not the function of CD8 T cells in herpes simplex virus type 1 latently infected trigeminal ganglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Broadening the repertoire of functional herpes simplex virus type 1-specific CD8 T cells reduces viral reactivation from latency in sensory ganglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymptomatic HLA-A*02:01-restricted epitopes from herpes simplex virus glycoprotein B preferentially recall polyfunctional CD8 T cells from seropositive asymptomatic individuals and protect HLA transgenic mice against ocular herpes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Associations of HLA-A, HLA-B and HLA-C alleles frequency with prevalence of herpes simplex virus infections and diseases across global populations: implication for the development of an universal CD8 T-cell epitope-based vaccine

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of novel virus-specific antigens by CD4⁺ and CD8⁺ T cells from asymptomatic HSV-2 seropositive and seronegative donors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lymphocyte Activation Gene 3 (LAG-3) modulates the ability of CD4 T-cells to be suppressed in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HLA-A02:01-restricted epitopes identified from the herpes simplex virus tegument protein VP11/12 preferentially recall polyfunctional effector memory CD8 T cells from seropositive asymptomatic individuals and protect humanized HLA-A*02:01 transgeni

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapeutic immunization with a mixture of herpes simplex virus 1 glycoprotein D-derived “asymptomatic” human CD8 T-cell epitopes decreases spontaneous ocular shedding in latently infected HLA transgenic rabbits: association with low frequency of l

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prior Corneal Scarification and Injection of Immune Serum are Not Required Before Ocular HSV-1 Infection for UV-B-Induced Virus Reactivation and Recurrent Herpetic Corneal Disease in Latently Infected Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Herpes Simplex Virus Latency-Associated Transcript Gene Is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8 T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell entry mechanisms of HSV: what we have learned in recent years.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combinatorial approach to cancer immunotherapy: strength in numbers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human Asymptomatic Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP13/14 (UL47) Preferentially Recall Polyfunctional Effector Memory CD44high CD62Llow CD8 TEM Cells and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocul

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CXCL10/CXCR3-Dependent Mobilization of Herpes Simplex Virus-Specific CD8 TEM and CD8 TRM Cells within Infected Tissues Allows Efficient Protection against Recurrent Herpesvirus Infection and Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential Inhibitory Receptor Expression on T Cells Delineates Functional Capacities in Chronic Viral Infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CXCL17 Chemokine-Dependent Mobilization of CXCR8 CD8 Effector Memory and Tissue-Resident Memory T Cells in the Vaginal Mucosa Is Associated with Protection against Genital Herpes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The NKG2D/NKG2DL Axis in the Crosstalk Between Lymphoid and Myeloid Cells in Health and Disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction and transcriptional regulation of the co-inhibitory gene module in T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Not All Immune Checkpoints Are Created Equal

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting Checkpoint Receptors and Molecules for Therapeutic Modulation of Natural Killer Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30619285

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3389/FIMMU.2018.02922

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