Genetic and structural insights into broad neutralization of hepatitis C virus by human V1-69 antibodies (Q60922369)

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17 April 2020

title

Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies (English)

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17 April 2020

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Leopold Kong

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Linling He

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17 April 2020

Jannick Prentoe

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17 April 2020

Elias Augestad

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Shaun Castillo

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Georg M Lauer

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Jens Bukh

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Jiang Zhu

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17 April 2020

Ian A Wilson

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Mansun Law

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17 April 2020

author name string

Erick Giang

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17 April 2020

Yuanzi Hua

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language of work or name

English

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publication date

2 January 2019

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volume

5

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issue

1

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17 April 2020

page(s)

eaav1882

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Genetic organization and diversity of the hepatitis C virus

17 April 2020

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12 December 2020

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V(H)1-69 gene is preferentially used by hepatitis C virus-associated B cell lymphomas and by normal B cells responding to the E2 viral antigen

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Glycosylation of hepatitis C virus envelope proteins

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Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120

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Coot: model-building tools for molecular graphics

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Characterization of host-range and cell entry properties of the major genotypes and subtypes of hepatitis C virus

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Evidence for cross-genotype neutralization of hepatitis C virus pseudo-particles and enhancement of infectivity by apolipoprotein C1

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Likelihood-enhanced fast translation functions

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The prevalence of hepatitis C virus infection in the United States, 1999 through 2002

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MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

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Inference of macromolecular assemblies from crystalline state

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Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge

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Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs.

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Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

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Antibody recognition of a highly conserved influenza virus epitope

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Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies

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Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models

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Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

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LigPlot : multiple ligand-protein interaction diagrams for drug discovery

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Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

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12 December 2020

Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate

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12 December 2020

Chronic hepatitis C virus infection breaks tolerance and drives polyclonal expansion of autoreactive B cells

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12 December 2020

Highly Conserved Protective Epitopes on Influenza B Viruses

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12 December 2020

Somatic Populations of PGT135-137 HIV-1-Neutralizing Antibodies Identified by 454 Pyrosequencing and Bioinformatics

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12 December 2020

Designing tomorrow's vaccines

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12 December 2020

Hepatitis C virus entry

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12 December 2020

Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

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12 December 2020

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

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12 December 2020

The ins and outs of hepatitis C virus entry and assembly

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12 December 2020

HCV transmission in industrialized countries and resource-constrained areas

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12 December 2020

De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts

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12 December 2020

Hepatitis C Virus E2 Envelope Glycoprotein Core Structure

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12 December 2020

CD81 and hepatitis C virus (HCV) infection.

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12 December 2020

Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2

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Antiviral treatment of hepatitis C.

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Rapid development of broadly influenza neutralizing antibodies through redundant mutations

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Toward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcoding

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From non-A, non-B hepatitis to hepatitis C virus cure

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12 December 2020

HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice.

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12 December 2020

Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor

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12 December 2020

Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design

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12 December 2020

Lack of evidence of an effect of direct-acting antivirals on the recurrence of hepatocellular carcinoma: Data from three ANRS cohorts

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12 December 2020

Early occurrence and recurrence of hepatocellular carcinoma in HCV-related cirrhosis treated with direct-acting antivirals

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12 December 2020

Hypervariable region 1 shielding of hepatitis C virus is a main contributor to genotypic differences in neutralization sensitivity.

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12 December 2020

Hepatitis C Treatment and Barriers to Eradication

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12 December 2020

Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Hepatitis C virus Broadly Neutralizing Monoclonal Antibodies Isolated 25 Years after Spontaneous Clearance

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12 December 2020

Structural flexibility at a major conserved antibody target on hepatitis C virus E2 antigen

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12 December 2020

Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A.

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12 December 2020

Broadly neutralizing antibodies with few somatic mutations and hepatitis C virus clearance

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12 December 2020

Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer

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12 December 2020

Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in VH1-69 Antibody Orientation on the HA Stem

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12 December 2020

Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis

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12 December 2020

Glycan Shielding and Modulation of Hepatitis C Virus Neutralizing Antibodies.

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Naive B Cells with High-Avidity Germline-Encoded Antigen Receptors Produce Persistent IgM and Transient IgG Memory B Cells

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The Neutralizing Face of Hepatitis C Virus E2 Envelope Glycoprotein.

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12 December 2020

Identifiers

DOI

10.1126/SCIADV.AAV1882

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30613781 AND SRC:MED&resulttype=core&format=json

17 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30613781 AND SRC:MED&resulttype=core&format=json

17 April 2020

PubMed publication ID

30613781

1 reference