Steroidal glycoalkaloids from target cytoskeletal proteins: an analysis (Q60921949)

April 2022 Public Data File from Crossref

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Antitumour effects of glycoalkaloids isolated from Solanum sodomaeum

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Identification of a phosphatidylinositol-4,5-bisphosphate-binding domain in the N-terminal region of ezrin

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Visualization and function of vimentin phosphorylation by cdc2 kinase during mitosis

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12 December 2020

Modulation of gelsolin function. Activation at low pH overrides Ca2 requirement

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12 December 2020

Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker

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Modulation of the interaction between G-actin and thymosin beta 4 by the ATP/ADP ratio: possible implication in the regulation of actin dynamics

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Actin filaments in yeast are unstable in the absence of capping protein or fimbrin

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Steroidal glycoalkaloids: nature and consequences of bioactivity

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Cytotoxic potential of the preparations from Solanum trilobatum and the effect of sobatum on tumour reduction in mice

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Gelsolin Binding to Phosphatidylinositol 4,5-Bisphosphate Is Modulated by Calcium and pH

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12 December 2020

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

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Inhibition of apoptosis by the actin-regulatory protein gelsolin

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12 December 2020

The Rhamnose Moiety of Solamargine Plays a Crucial Role in Triggering Cell Death by Apoptosis

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12 December 2020

Neuroprotective effects of gelsolin during murine stroke

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12 December 2020

Actin stabilization by jasplakinolide enhances apoptosis induced by cytokine deprivation.

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12 December 2020

Antineoplastic agents. III: Steroidal glycosides from Solanum nigrum

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Monoclonal antibody to HER-2/neureceptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene.

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Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro

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12 December 2020

Alterations of the actin polymerization status as an apoptotic morphological effector in HL-60 cells

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12 December 2020

Latrunculin B has different effects on pollen germination and tube growth.

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12 December 2020

Proteins of the ADF/cofilin family: essential regulators of actin dynamics

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12 December 2020

Gelsolin in complex with phosphatidylinositol 4,5-bisphosphate inhibits caspase-3 and -9 to retard apoptotic progression

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12 December 2020

Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release

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12 December 2020

Steroidal oligoglycosides from Solanum nigrum

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12 December 2020

Neurodegenerative stimuli induce persistent ADF/cofilin-actin rods that disrupt distal neurite function

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12 December 2020

CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway

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Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

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Jasplakinolide induces apoptosis in various transformed cell lines by a caspase-3-like protease-dependent pathway

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Anticancer activity evaluation of the solanum glycoalkaloid solamargine. Triggering apoptosis in human hepatoma cells

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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beta-Thymosins, small acidic peptides with multiple functions

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Protein kinases required for segregation of vimentin filaments in mitotic process

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Chromatographic procedures for the isolation of plant steroids

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12 December 2020

Antiviral isoflavonoid sulfate and steroidal glycosides from the fruits of Solanum torvum

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12 December 2020

Conserved segments 1A and 2B of the intermediate filament dimer: their atomic structures and role in filament assembly

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12 December 2020

Molecular properties that influence the oral bioavailability of drug candidates

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Drugs, leads, and drug-likeness: an analysis of some recently launched drugs

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12 December 2020

Induction of apoptosis and CD10/neutral endopeptidase expression by jaspamide in HL-60 line cells

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12 December 2020

Signal-mediated depolymerization of actin in pollen during the self-incompatibility response

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12 December 2020

A genomics approach to the early stages of triterpene saponin biosynthesis in Medicago truncatula

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12 December 2020

Inhibition of actin polymerization enhances commitment to and execution of apoptosis induced by withdrawal of trophic support

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12 December 2020

ADF/cofilin mediates actin cytoskeletal alterations in LLC-PK cells during ATP depletion

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12 December 2020

Actin dependent CD95 internalization is specific for Type I cells

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The mitochondrial voltage-dependent anion channel (VDAC) as a therapeutic target for initiating cell death.

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12 December 2020

Actin cytoskeletal architecture regulates nitric oxide-induced apoptosis, dedifferentiation, and cyclooxygenase-2 expression in articular chondrocytes via mitogen-activated protein kinase and protein kinase C pathways

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12 December 2020

Ripe fruit of Solanum nigrum L. inhibits cell growth and induces apoptosis in MCF-7 cells

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12 December 2020

Furostanol saponins from Tribulus terrestris

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12 December 2020

The gelsolin family of actin regulatory proteins: modular structures, versatile functions.

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12 December 2020

Association of Villin with Phosphatidylinositol 4,5-Bisphosphate Regulates the Actin Cytoskeleton

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12 December 2020

Effect of Dried Fruits of Solanum nigrum LINN against CCl4-Induced Hepatic Damage in Rats

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12 December 2020

Mechanism of actin polymerization in cellular ATP depletion

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12 December 2020

Mitochondrial translocation of cofilin is an early step in apoptosis induction.

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12 December 2020

Spirostanol and furostanol glycosides from the fresh tubers of Polianthes tuberosa

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12 December 2020

Neuronal gelsolin prevents apoptosis by enhancing actin depolymerization

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12 December 2020

GEMDOCK: a generic evolutionary method for molecular docking.

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12 December 2020

Solution structures of the C-terminal headpiece subdomains of human villin and advillin, evaluation of headpiece F-actin-binding requirements

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12 December 2020

Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells

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12 December 2020

Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression

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12 December 2020

UCSF Chimera--a visualization system for exploratory research and analysis

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12 December 2020

A 150-kDa glycoprotein isolated from Solanum nigrum L. has cytotoxic and apoptotic effects by inhibiting the effects of protein kinase C alpha, nuclear factor-kappa B and inducible nitric oxide in HCT-116 cells

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12 December 2020

Action of solamargine on human lung cancer cells--enhancement of the susceptibility of cancer cells to TNFs

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12 December 2020

Potato glycoalkaloids and adverse effects in humans: an ascending dose study

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12 December 2020

Structure-function relationship for saponin effects on cell cycle arrest and apoptosis in the human 1547 osteosarcoma cells: a molecular modelling approach of natural molecules structurally close to diosgenin.

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12 December 2020

Inhibition of Alzheimer's amyloid-beta peptide-induced reduction of mitochondrial membrane potential and neurotoxicity by gelsolin.

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12 December 2020

The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it

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12 December 2020

The identification of apoptosis-related residues in human thymosin beta-10 by mutational analysis and computational modeling

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12 December 2020

Anticarcinogenic effects of glycoalkaloids from potatoes against human cervical, liver, lymphoma, and stomach cancer cells

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12 December 2020

A conserved trimerization motif controls the topology of short coiled coils

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12 December 2020

Antiulcerogenic and ulcer healing effects of Solanum nigrum (L.) on experimental ulcer models: possible mechanism for the inhibition of acid formation

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12 December 2020

Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis

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12 December 2020

Actin cytoskeleton derangement induces apoptosis in renal ischemia/reperfusion.

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12 December 2020

Posttranslational N-myristoylation is required for the anti-apoptotic activity of human tGelsolin, the C-terminal caspase cleavage product of human gelsolin.

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12 December 2020

Formation of actin-ADF/cofilin rods transiently retards decline of mitochondrial potential and ATP in stressed neurons

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12 December 2020

Microtubules: forgotten players in the apoptotic execution phase

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12 December 2020

Coronins: the return of the crown

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12 December 2020

Molluscicidal activity of Solanum species of the Northeast of Brazil on Biomphalaria glabrata.

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12 December 2020

A direct interaction between actin and vimentin filaments mediated by the tail domain of vimentin

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12 December 2020

Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis

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12 December 2020

Steroidal saponins from Solanum nigrum

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12 December 2020

Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex

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12 December 2020

Saponins, classification and occurrence in the plant kingdom

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12 December 2020

Pro-Survival Role of Gelsolin in Mouse -Cells

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12 December 2020

HeLa cells treated with phytoglycoprotein (150 kDa) were killed by activation of caspase 3 via inhibitory activities of NF-kappaB and AP-1.

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12 December 2020

Gelsolin segment 5 inhibits HIV-induced T-cell apoptosis via Vpr-binding to VDAC.

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12 December 2020

Antioxidant, antimicrobial and cytotoxic activities of selected medicinal plants from Yemen.

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12 December 2020

Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge

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12 December 2020

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

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12 December 2020

The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin

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12 December 2020

Isolation of steroidal glycosides from Solanum xanthocarpum and studies on their antifungal activities

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12 December 2020

Solamargine induces apoptosis and sensitizes breast cancer cells to cisplatin

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12 December 2020

Assessment of predictions submitted for the CASP7 function prediction category.

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12 December 2020

Induction of apoptosis in HepG2 cells by solanine and Bcl-2 protein

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12 December 2020

Hepatoprotective effects of Solanum nigrum Linn extract against CCl(4)-induced oxidative damage in rats

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12 December 2020

Solasodine glycoalkaloids: a novel topical therapy for basal cell carcinoma. A double-blind, randomized, placebo-controlled, parallel group, multicenter study

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12 December 2020

Providing cellular signposts--post-translational modifications of intermediate filaments.

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12 December 2020

Inhibitory effect of Solanum nigrum on thioacetamide-induced liver fibrosis in mice.

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12 December 2020

A role for actin in regulating apoptosis/programmed cell death: evidence spanning yeast, plants and animals.

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12 December 2020

Aqueous extract of Solanum nigrum inhibit growth of cervical carcinoma (U14) via modulating immune response of tumor bearing mice and inducing apoptosis of tumor cells

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12 December 2020

Antitumor effects of total alkaloids isolated from Solanum nigrum in vitro and in vivo.

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12 December 2020

Anti-seizure activity of the aqueous leaf extract of Solanum nigrum linn (solanaceae) in experimental animals

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12 December 2020

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

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12 December 2020

Antitumor and immunomodulating effects of polysaccharides isolated from Solanum nigrum Linne.

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12 December 2020

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

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12 December 2020

Ca2 binding by domain 2 plays a critical role in the activation and stabilization of gelsolin

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12 December 2020

Proteome of acidic phospholipid-binding proteins: spatial and temporal regulation of Coronin 1A by phosphoinositides

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12 December 2020

Withaferin A targets intermediate filaments glial fibrillary acidic protein and vimentin in a model of retinal gliosis

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12 December 2020

MolProbity: all-atom structure validation for macromolecular crystallography

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12 December 2020

Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition

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12 December 2020

Apoptosis inducing activity of steroidal constituents from Solanum xanthocarpum and Asparagus racemosus.

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12 December 2020

Chemical Composition of Solanum nigrum Linn Extract and Induction of Autophagy by Leaf Water Extract and Its Major Flavonoids in AU565 Breast Cancer Cells

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12 December 2020

Saponins as cytotoxic agents: a review.

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12 December 2020

In-vitro antiviral activity of Solanum nigrum against Hepatitis C Virus

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12 December 2020

Bioactivities of glycoalkaloids and their aglycones from Solanum species.

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12 December 2020

Solanum nigrum: current perspectives on therapeutic properties

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12 December 2020

Activation of F-actin binding capacity of ezrin: synergism of PIP₂ interaction and phosphorylation

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12 December 2020

Prediction of activity spectra for substances.

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12 December 2020

Actin filament severing by cofilin is more important for assembly than constriction of the cytokinetic contractile ring

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12 December 2020

Selective cell cycle arrest and induction of apoptosis in human prostate cancer cells by a polyphenol-rich extract of Solanum nigrum

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12 December 2020

The chloroform fraction of Solanum nigrum suppresses nitric oxide and tumor necrosis factor-α in LPS-stimulated mouse peritoneal macrophages through inhibition of p38, JNK and ERK1/2.

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12 December 2020

Pivotal role of the RanBP9-cofilin pathway in Aβ-induced apoptosis and neurodegeneration

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12 December 2020

Dynamic behaviors of vimentin induced by interaction with GlcNAc molecules

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12 December 2020

The actin cytoskeleton as a sensor and mediator of apoptosis

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12 December 2020

Synthesis and PASS-assisted in silico approach of some novel 2-substituted benzimidazole bearing a pyrimidine-2, 4, 6(trione) system as mucomembranous protector.

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12 December 2020

Antiproliferative Effect of Solanum nigrum on Human Leukemic Cell Lines

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12 December 2020

Post-translational modifications of intermediate filament proteins: mechanisms and functions

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12 December 2020

Intermediate filaments: a dynamic network that controls cell mechanics

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12 December 2020

Structural basis of thymosin-β4/profilin exchange leading to actin filament polymerization

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12 December 2020

Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes

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12 December 2020

Intermediate Filaments Play a Pivotal Role in Regulating Cell Architecture and Function

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12 December 2020

Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites

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12 December 2020

Chemical Structure-Related Drug-Like Criteria of Global Approved Drugs

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12 December 2020

Synthesis, molecular properties, toxicity and biological evaluation of some new substituted imidazolidine derivatives in search of potent anti-inflammatory agents

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12 December 2020

A Review of Bioinsecticidal Activity of Solanaceae Alkaloids

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12 December 2020

Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases

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12 December 2020

Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin.

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12 December 2020

Evaluation of uttroside B, a saponin from Solanum nigrum Linn, as a promising chemotherapeutic agent against hepatocellular carcinoma

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12 December 2020

In silico PASS analysis and determination of antimycobacterial, antifungal, and antioxidant efficacies of maslinic acid in an extract rich in pentacyclic triterpenoids.

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12 December 2020

Elucidation of GlcNAc-binding properties of type III intermediate filament proteins, using GlcNAc-bearing polymers

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12 December 2020

ATP competes with PIP2 for binding to gelsolin

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12 December 2020