Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder (Q60440984)

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scientific article published on 16 October 2007

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English	Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder	scientific article published on 16 October 2007

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8 January 2020

Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder (English)

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8 January 2020

bipolar disorder

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Kyla Pennington

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Carmine Pariante

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P Dicker

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A Fagan

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M J Dunn

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Molecular Psychiatry

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8 January 2020

The role of the prefrontal cortex in higher cognitive functions

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Functional and Anatomical Aspects of Prefrontal Pathology in Schizophrenia

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Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging

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Volumetric measure of the frontal and temporal lobe regions in schizophrenia: relationship to negative symptoms

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Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison.

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Subgenual prefrontal cortex abnormalities in mood disorders

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Volumetric MRI studies of mood disorders: do they distinguish unipolar and bipolar disorder?

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Neuroimaging studies of mood disorder effects on the brain

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Decreased somal size of deep layer 3 pyramidal neurons in the prefrontal cortex of subjects with schizophrenia

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Neuronal and glial somal size in the prefrontal cortex: a postmortem morphometric study of schizophrenia and Huntington disease

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Evidence for a decrease in basilar dendrites of pyramidal cells in schizophrenic medial prefrontal cortex

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7 January 2021

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Pathology of layer V pyramidal neurons in the prefrontal cortex of patients with schizophrenia.

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Structural abnormalities of subicular dendrites in subjects with schizophrenia and mood disorders: preliminary findings

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Lamina-specific reductions in dendritic spine density in the prefrontal cortex of subjects with schizophrenia

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Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder.

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7 January 2021

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Multivariate analysis of prefrontal cortical data from the Stanley Foundation Neuropathology Consortium

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7 January 2021

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Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains

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Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia

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Microarray analysis of gene expression in the prefrontal cortex in schizophrenia: a preliminary study

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Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia

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7 January 2021

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Application of cDNA microarrays to examine gene expression differences in schizophrenia

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7 January 2021

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Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex

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7 January 2021

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Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia.

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Hippocampal complexin proteins and cognitive dysfunction in schizophrenia

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Schizophrenia: a genetic disorder of the synapse?

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The synaptic hypothesis of schizophrenia.

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A comparison of selected mRNA and protein abundances in human liver

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Correlation between protein and mRNA abundance in yeast

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Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium

1 reference

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7 January 2021

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Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress

1 reference

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7 January 2021

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A proteome analysis of the anterior cingulate cortex gray matter in schizophrenia

1 reference

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7 January 2021

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Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: Evidence for disease-associated changes.

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7 January 2021

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Mitochondrial related gene expression changes are sensitive to agonal-pH state

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Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions

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7 January 2021

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Postmortem changes in the level of brain proteins.

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Dihydropyrimidinase related protein-2 as a biomarker for temperature and time dependent post mortem changes in the mouse brain proteome

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Sample application by in-gel rehydration improves the resolution of two-dimensional electrophoresis with immobilized pH gradients in the first dimension

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Improved and simplified in-gel sample application using reswelling of dry immobilized pH gradients

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Approach to stationary two-dimensional pattern: influence of focusing time and immobiline/carrier ampholytes concentrations

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A modified silver staining protocol for visualization of proteins compatible with matrix-assisted laser desorption/ionization and electrospray ionization-mass spectrometry

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7 January 2021

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Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

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7 January 2021

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Hippocampal synaptic pathology in schizophrenia, bipolar disorder and major depression: a study of complexin mRNAs

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7 January 2021

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Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins

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Mutation analysis of SYNJ1: a possible candidate gene for chromosome 21q22-linked bipolar disorder

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7 January 2021

based on heuristic

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Reductions in cholesterol and synaptic markers in association cortex in mood disorders.

1 reference

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Identification and molecular characterization of Unc-33-like phosphoprotein (Ulip), a putative mammalian homolog of the axonal guidance-associated unc-33 gene product.

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Cellular localization and subcellular distribution of Unc-33-like protein 6, a brain-specific protein of the collapsin response mediator protein family that interacts with the neuronal glycine transporter 2.

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Proteomic analysis of NMDA receptor-adhesion protein signaling complexes

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Intersectin regulates fission and internalization of caveolae in endothelial cells.

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Altered levels of the synaptosomal associated protein SNAP-25 in hippocampus of subjects with mood disorders and schizophrenia

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SNAP-25 reduction in the hippocampus of patients with schizophrenia.

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Expression of NMDAR1, GluR1, GluR7, and KA1 glutamate receptor mRNAs is decreased in frontal cortex of "neuroleptic-free" schizophrenics: evidence on reversible up-regulation by typical neuroleptics.

1 reference

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7 January 2021

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Increased levels of expression of an NMDAR1 splice variant in the superior temporal gyrus in schizophrenia

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7 January 2021

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Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals

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Changes in NMDA receptor subunits and interacting PSD proteins in dorsolateral prefrontal and anterior cingulate cortex indicate abnormal regional expression in schizophrenia

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7 January 2021

based on heuristic

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Altered expression of 14-3-3 genes in the prefrontal cortex of subjects with schizophrenia

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7 January 2021

based on heuristic

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A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia

1 reference

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7 January 2021

based on heuristic

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Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population

1 reference

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7 January 2021

based on heuristic

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The emerging role of glutamate in the pathophysiology and treatment of schizophrenia

1 reference

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7 January 2021

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The genetics of schizophrenia: glutamate not dopamine?

1 reference

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7 January 2021

based on heuristic

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Cellular plasticity cascades: targets for the development of novel therapeutics for bipolar disorder

1 reference

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7 January 2021

based on heuristic

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NMDA receptor subunit NRI and postsynaptic protein PSD-95 in hippocampus and orbitofrontal cortex in schizophrenia and mood disorder

1 reference

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7 January 2021

based on heuristic

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Expression profiling the human septin gene family

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High rates of schizophrenia in adults with velo-cardio-facial syndrome.

1 reference

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7 January 2021

based on heuristic

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Molecular characterization of deletion breakpoints in adults with 22q11 deletion syndrome

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A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder and effect of Val158Met genotype

1 reference

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Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4.

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The septin CDCrel-1 binds syntaxin and inhibits exocytosis

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The septin Sept5/CDCrel-1 competes with alpha-SNAP for binding to the SNARE complex

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based on heuristic

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Differential localization of septins in the mouse brain

1 reference

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Localization of a novel septin protein, hCDCrel-1, in neurons of human brain

1 reference

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Identification of septins in neurofibrillary tangles in Alzheimer's disease

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SEPT5_v2 is a parkin-binding protein

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Superoxide, neuroleptics and the ubiquinone and cytochrome b5 reductases in brain and lymphocytes from normals and schizophrenic patients

1 reference

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based on heuristic

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Mitochondrial function is differentially altered in the basal ganglia of chronic schizophrenics

1 reference

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7 January 2021

based on heuristic

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Evidence for a mitochondrial oxidative phosphorylation defect in brains from patients with schizophrenia

1 reference

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based on heuristic

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A mitochondrial DNA sequence variant associated with schizophrenia and oxidative stress

1 reference

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based on heuristic

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Mitochondrial dysfunction in bipolar disorder

1 reference

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7 January 2021

based on heuristic

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Regional cerebral glucose metabolic abnormalities in bipolar II depression

1 reference

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7 January 2021

based on heuristic

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Gene expression differences in bipolar disorder revealed by cDNA array analysis of post-mortem frontal cortex

1 reference

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7 January 2021

based on heuristic

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Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis

1 reference

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7 January 2021

based on heuristic

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Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes

1 reference

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7 January 2021

based on heuristic

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An online database for brain disease research

1 reference

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7 January 2021

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Immunohistochemical localization of phosphorylated glial fibrillary acidic protein in the prefrontal cortex and hippocampus from patients with schizophrenia, bipolar disorder, and depression

1 reference

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7 January 2021

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Glial fibrillary acidic protein and glutamine synthetase in subregions of prefrontal cortex in schizophrenia and mood disorder

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7 January 2021

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10.1038/SJ.MP.4002098

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Europe PubMed Central

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8 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

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8 January 2020

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