Hepatitis B Spliced Protein (HBSP) Suppresses Fas-Mediated Hepatocyte Apoptosis via Activation of PI3K/Akt Signaling (Q59352761)

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Wan-Nan Chen

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Zhen-Tang Jing

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Xin-Jian Lin

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Xu Lin

Characterization and genetic analysis of alternatively spliced transcripts of hepatitis B virus in infected human liver tissues and transfected HepG2 cells

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language of work or name

English

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publication date

1 December 2018

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published in

Journal of Virology

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volume

92

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issue

23

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cites work

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Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule

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Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

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Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage.

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Abrogation of p53-induced apoptosis by the hepatitis B virus X gene

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Fas antigen expression in liver tissues of patients with chronic hepatitis B

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Apoptosis by death factor

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FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

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Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor α

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In situ investigation of Fas/FasL expression in chronic hepatitis B infection and related liver diseases

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Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

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Heterogeneity and common features of defective hepatitis B virus genomes derived from spliced pregenomic RNA.

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X-gene Product of Hepatitis B Virus Induces Apoptosis in Liver Cells

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The hepatitis B virus HBx protein inhibits caspase 3 activity.

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The role of c-FLIP in modulation of CD95-induced apoptosis

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

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In vivo expression of a new hepatitis B virus protein encoded by a spliced RNA.

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12 December 2020

Hepatitis B virus X protein inhibits transforming growth factor-beta -induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway

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Hepatocyte growth factor promotes cell survival from fas-mediated cell death in hepatocellular carcinoma cells via Akt activation and Fas-death-inducing signaling complex suppression

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12 December 2020

X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway

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12 December 2020

The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing

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12 December 2020

Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappa B.

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12 December 2020

Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways

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12 December 2020

TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes

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Molecular ordering of the initial signaling events of CD95.

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12 December 2020

The hepatitis B virus X protein abrogates Bcl-2-mediated protection against Fas apoptosis in the liver

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[Structural and functional analysis of 2.2 kb spliced variant of hepatitis B virus genomes isolated from liver tissues from hepatocellular carcinoma patients]

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12 December 2020

NF-kappaB activation by hepatitis B virus X (HBx) protein shifts the cellular fate toward survival.

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12 December 2020

The expression of hepatitis B spliced protein (HBSP) encoded by a spliced hepatitis B virus RNA is associated with viral replication and liver fibrosis

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12 December 2020

Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45

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12 December 2020

Hepatocyte growth factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt.

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12 December 2020

High level expression of apoptosis inhibitor in hepatoma cell line expressing Hepatitis B virus

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12 December 2020

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

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12 December 2020

Inhibition of the phosphatidylinositol 3'-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells.

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12 December 2020

The HBSP gene is expressed during HBV replication, and its coded BH3-containing spliced viral protein induces apoptosis in HepG2 cells

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12 December 2020

Hepatitis B virus sensitizes hepatocytes to TRAIL-induced apoptosis through Bax.

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12 December 2020

Met signals hepatocyte survival by preventing Fas-triggered FLIP degradation in a PI3k-Akt-dependent manner.

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Apoptosis: a review of programmed cell death

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Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria

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Expression of defective hepatitis B virus particles derived from singly spliced RNA is related to liver disease

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12 December 2020

Many checkpoints on the road to cell death: regulation of Fas-FasL interactions and Fas signaling in peripheral immune responses

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12 December 2020

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

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12 December 2020

Hepatitis B spliced protein (HBSP) generated by a spliced hepatitis B virus RNA participates in abnormality of fibrin formation and functions by binding to fibrinogen γ chain

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12 December 2020

ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor.

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12 December 2020

Actin-independent exclusion of CD95 by PI3K/AKT signalling: implications for apoptosis

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12 December 2020

miR-29c targets TNFAIP3, inhibits cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma.

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12 December 2020

Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating the Src/PI3K/Akt pathway

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12 December 2020

HBsAg inhibits the translocation of JTB into mitochondria in HepG2 cells and potentially plays a role in HCC progression

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12 December 2020

Signaling in control of cell growth and metabolism

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12 December 2020

Interaction of the hepatitis B spliced protein with cathepsin B promotes hepatoma cell migration and invasion

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12 December 2020

Hepatitis B virus splicing is enhanced prior to development of hepatocellular carcinoma

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12 December 2020

Hepatitis B virus disrupts mitochondrial dynamics: induces fission and mitophagy to attenuate apoptosis

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12 December 2020

Hepatitis B virus infection

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12 December 2020

Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation

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12 December 2020

Synergism of PI3K/Akt inhibition and Fas activation on colon cancer cell death

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12 December 2020

Hepatitis B virus core protein sensitizes hepatocytes to tumor necrosis factor-induced apoptosis by suppression of the phosphorylation of mitogen-activated protein kinase kinase 7

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12 December 2020

Hepatitis B virus core protein inhibits Fas-mediated apoptosis of hepatoma cells via regulation of mFas/FasL and sFas expression

1 reference

12 December 2020

Alternative splicing-regulated protein of hepatitis B virus hacks the TNF-α-stimulated signaling pathways and limits the extent of liver inflammation

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12 December 2020

A novel mutant 10Ala/Arg together with mutant 144Ser/Arg of hepatitis B virus X protein involved in hepatitis B virus-related hepatocarcinogenesis in HepG2 cell lines

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12 December 2020

Global strategies are required to cure and eliminate HBV infection.

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12 December 2020

Inhibition of apoptosis by oncogenic hepatitis B virus X protein: Implications for the treatment of hepatocellular carcinoma

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12 December 2020

Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity.

1 reference

12 December 2020

Interference of Apoptosis by Hepatitis B Virus

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12 December 2020

Association of cytosolic sialidase Neu2 with plasma membrane enhances Fas-mediated apoptosis by impairing PI3K-Akt/mTOR-mediated pathway in pancreatic cancer cells

1 reference

12 December 2020

A Novel AKT Activator, SC79, Prevents Acute Hepatic Failure Induced by Fas-Mediated Apoptosis of Hepatocytes.

1 reference

12 December 2020